Quercetin and Zinc: Dr Zelenko Prevention and Treatment Protocol (2023)
Quercetin is a natural antihistamine and anti-inflammatory plant pigment that boosts your immune system and may work to control viral replication, according to some research. It allows zinc to exert its proven antiviral properties; in treating COVID-19, quercetin may also lower inflammation, help clear mucus, prevent ventilator-induced damage and support immunity.According to the research, quercetin has been shown to help fight obesity, Type 2 diabetes, circulatory dysfunction, chronic inflammation and mood disorders. It has even been found to help lower blood pressure. Researchers have found that quercetin can trigger tumor regression and begin the process of apoptosis. This is programmed cell death, without which cells can grow uninterrupted and develop into cancerous growths.
- As of January 2023, evidence from 9 studies on the topic of quercetin and COVID-19 have been published (c19quercetin.com).
- As of January 2023, more than 35 studies on the topic of zinc and COVID-19 have been published. Check out the evidence tracker on zinc and COVID-19 from c19zinc.com (constantly updated).
- Zinc ion can tightly bind to a number of substances, such as citric acid, potentially preventing the release of free zinc ions from lozenges in the oropharyngeal region. Zinc gluconate lozenges have been suggested to be less effective than zinc acetate lozenges, but a meta-analysis of seven trials with a total of 575 common cold participants did not find significant difference between lozenges composed of the two salts. (BMJ Open. Jan 2020)
- A high intake of zinc (150 mg a day or above) and vitamin C (over 1,500 mg a day) may induce copper deficiency by competing with copper for absorption in the intestine. (Ref)
- The AAPS (Association of American Physicians and Surgeons) recommends zinc sulfate, gluconate or citrate. These forms are available in pharmacies, health food stores, and sold online. Zinc sulfate 220 mg provides 50 mg elemental zinc, the recommended anti-viral dose.
Zelenko Covid-19 Prophylaxis Protocol
Low Risk Patients
Young healthy people do not need prophylaxis against COVID-19. In young and healthy people, this infection causes mild cold-like symptoms. It is advantageous for these patients to be exposed to COVID-19, build up their antibodies and have their immune system clear the virus. This will facilitate the development of herd immunity and help prevent future Covid-19 pandemics. However, if these patients desire prophylaxis against COVID-19, then they should take the protocol noted below.
Moderate Risk Patients
Patients from this category are healthy but have high potential viral-load exposure. This group includes medical personnel, caregivers of high-risk patients, people who use public transportation, first responders and other essential personnel who are crucial to the continued functioning of society. These patients should be encouraged to take prophylaxis against Covid-19 in accordance with the protocol noted below.
High Risk Patients
Patients are considered high risk if they are over the age of 45, or if they are younger than 45 but they have comorbidities, that is, they have other health conditions that put them at risk. These patients have between a 5 to 10% mortality rate if they are infected with Covid-19. These patients should be strongly encouraged to take prophylaxis against Covid-19 in accordance with the protocol noted below.
Vitamin D3 5000 iu 1 time a day (vdnmeta.com)
Vitamin C 250 - 500 mg 1 time a day (PubMed)
Quercetin 250 mg 1 time a day until a safe and efficacious vaccine becomes available (J. Agric. Food Chem. 2014)
If Quercetin is unavailable, then use Epigallocatechin-gallate (EGCG) 200mg 1 time a day (J. Agric. Food Chem. 2014)
In addition to what is recommended by the zelenko protocol, the FLCCC I-MASK+ prevention protocol includes mouthwash, melatonin and ivermectin as part of the prevention protocol. However, the I-MASK+ prevention protocol does not categorize the patients into low risk or high risk. For the zelenko protocol, hydroxychloroquine is only recommended for those in high risk category.
Zelenko Protocol - Treatment Plan for Patients with COVID-19 symptoms
Fundamental Principles (Dr Zelenko Protocol When to Start)
Patient CategoriesLow risk patient - Younger than 45, no co-morbidities, and clinically stable
High risk patient - Older than 45, younger than 45 with co-morbidities, or clinically unstable
Low risk patients - over the counter options:
1. Zinc (Elemental) 50 mg 1 time a day for 7 days (PubMed)
2.1. Quercetin 500 mg 2 times a day for 7 days (PubMed) OR
2.2. Epigallocatechin-gallate (EGCG) 400 mg 1 time a day for 7 days (J. Agric. Food Chem. 2014)
4. Vitamin D3 5000 IU 1 time a day for 7 days
Moderate / High risk patients
Ivermectin 0.4-0.5mg/kg/day for 5-7 days (ivmmeta.com) (Find a Doctor)
Either or both HCQ and IVM can be used, and if one only, the second agent may be added after about 2 days of treatment if obvious recovery has not yet been observed etc.
If HCQ is not available, Quercetin 500mg 3 times a day for 7 days OR EGCG 400mg 2 times a day for 7 days
In combination with the above (AND):
1. Elemental Zinc 50 - 100 mg 1 time a day for 7 days
2. Hydroxychloroquine (HCQ) 200mg 2 times a day for 7 days (Find a Doctor)
3. Azithromycin 500mg 1 time a day for 5 days OR Doxycycline 100mg 2 times a day for 7 days
4. Vitamin C 1000 mg 1 time a day for 7 days
5. Vitamin D3 10,000 IU 1 time a day for 7 days
Other treatment options
- Dexamethasone 6-12mg 1 time a day for 7 days OR Prednisone 20mg twice a day for 7 days, taper as needed.
- Budesonide 1mg/2cc solution via nebulizer twice a day for 7 days.
- Blood thinners (i.e. Aspirin, Lovenox, Eliquis, Xarelto, Pradaxa) (Amazon)
- Colchicine 0.6mg 2-3 times a day for 5-7 days.
- Monoclonal antibodies.
- Home IV fluids and oxygen.
In addition to what is recommended by the zelenko protocol, the FLCCC I-MASK+ treatment protocol includes mouthwash, melatonin and ivermectin and incorporates repurposed and newer agents like anti-androgens and fluvoxamine. The I-MASK+ treatment protocol also categorises the treatment agents into first line agents and second line agents for those who do not respond to first line agents and for those high risk patients with co-morbidities.
- Zinc is critical. It helps block the virus from multiplying. Hydroxychloroquine is the carrier taking zinc INTO the cells to do its job.
- Vitamin D3: Preferable in oil capsules for better absorption.
- Should quercetin be taken with zinc? Yes. Quercetin works best when taken with vitamin C and Bromelain, as vitamin C helps activate it and bromelain helps with the absorption. Vitamin C does not affect the absorption of normal dietary levels of zinc (Ref). Further, quercetin helps the transport of zinc across the cell membrane as a zinc ionophore.
- Although ivermectin and hydroxychloroquine are relatively safe drugs, they are still synthetic chemicals that can have side effects. Vitamin D, C, Zinc and Quercetin are nutrients that your body require for optimal health. Nutrients are safer alternatives especially if your risk is low e.g. age below 50 and no other chronic illness. Discuss with your doctor on the benefit vs risk for each treatment.
- Quercetin has one moderate drug interaction with warfarin. Do not take quercetin without medical advice if you are using warfarin.
In an effort to make it easier for patients, Dr Zelenko has developed an oral supplement that contains all four key ingredients: vitamin C, quercetin, vitamin D3 and zinc. It’s referred to as 'Z-Stack Supplement'.
Z-Stack Vitamin cocktail provides key ingredients needed in order to help your body fight off this deadly invader. The Z-Stack Vitamins are Kosher certified, GMP certified and made in the USA.
Note: To get 5% OFF, please use this coupon code: drfrancis
About Dr Vladimir ZelenkoHe graduated with a B.A. degree with high honors in Chemistry from Hofstra University. After receiving an academic scholarship to attend S.U.N.Y. at Buffalo School of Medicine, he earned his M.D. degree in May 2000. Dr. Zelenko completed his family medicine residency at South Nassau Communities Hospital in Oceanside, N.Y. in May 2004. Since then, Dr. Zelenko has practiced family medicine in New York’s Hudson Valley. He has been described by his patients as like a family member to thousands of families, and is a medical adviser to the volunteer ambulance corps in Kiryas Joel, New York.
When asked about studies that seemed to discredit the efficacy of HCQ in treating the coronavirus, Zelenko explained “You don’t fire a gun without a bullet in it and then say the gun doesn’t work when you don’t kill the target. The studies that were done on HCQ did not include the use of Zinc. HCQ is what opens the cell and enables Zinc to attack the virus. One is not effective without the other, or without a suitable substitute for HCQ. The studies were designed to fail.”
Dr. Zelenko says that both prophylaxis measures and actual case treatments need to be customized to the individual. As a general rule, he says, those people who are in the higher risk groups, both by age and by other pre-existing conditions, require more aggressive actions on both the preventative and diagnostic side.
“This virus remains relatively stable inside the host for about the first five days,” Zelenko said. “After that it starts to multiply rapidly. It also starts to migrate from sinus to lungs and cardio areas where involvement becomes more severe and treatment becomes more difficult. The key is early intervention.” Zelenko again mentioned his 84% success rate in high-risk patients.