Dr Peter McCullough Protocol: Hydroxychloroquine and Home Treatment for COVID-19 (2022)

Well-respected North Texas cardiologist, Dr. Peter McCullough has impeccable academic credentials. He's an internist, cardiologist, epidemiologist, a full professor of medicine at Texas A&M College of Medicine in Dallas. He also has a master's degree in public health and is known for being one of the top five most-published medical researchers in the United States and is the editor of two medical journals.

dr peter mccullough
McCullough et al. Reviews in Cardiovascular Medicine, 2020

As published in Dr Peter McCullough's substack (Oct 14, 2022):

The current Omicron infection is characteristically mild with limited pulmonary and systemic involvement. For those who are having second and third infections it will be even more mild often indistinguishable from the common cold. All of the agents mentioned in this stack have reasonable supportive evidence. The therapeutic aims are to address viral replication, inflammation, and thrombosis. 

Patients at negligible and low risk can self-manage with viricidal nasal washes and the “OTC Bundle” which includes zinc, vitamin D, vitamin C, quercetin, famotidine (at four times the package dose—80 mg a day), and it’s reasonable to include aspirin 325 mg a day (Nature). 

For very high-risk elderly patients with significant medical problems, for example, oxygen-dependent cardio-pulmonary disease monoclonal antibodies can be given as a one-time infusion preferably on days 1-3.  

For those at moderate and above risk, it is reasonable to choose one oral antiviral (hydroxychloroquine, ivermectin, Paxlovid, molnupiravir) and consider combining it with an intracellular antibiotic (e.g., doxycycline or azithromycin) to cover concomitant atypical organisms and superimposed bacterial bronchitis. For fever control and inflammation, non-steroidal anti-inflammatories (e.g., naproxen) are favored over acetaminophen (R).

In the Omicron wave, corticosteroids can be streamlined to inhaled budesonide and or oral prednisone. Beyond these principles the remainder of the McCullough Protocol© can be stylized to the patient and their particular history and symptoms with the goal of ameliorating the intensity and duration of symptoms and by that mechanism, reducing the risk of hospitalization or death. For example, patients with pleuropericardial symptoms or prior chest surgery, colchicine can be added and is well-supported by the largest outpatient placebo-controlled trial (R). If bedbound, immobile, or tendency for blood clotting, then anticoagulation with low-molecular weight heparin by injection or oral anticoagulants is prudent.

The community standard of care for COVID-19 was developed by doctors in the field who learned how to treat the infection using their clinical judgement and available sources of evidence—not by government agencies, state medical boards, or royal colleges of physicians. Having nearly three years of experience in ambulatory management, Dr. McCullough has learned from experts around the globe that no single drug is necessary nor sufficient to treat COVID-19. Yes, that means that the syndrome can be treated without antiviral agents as reported by Dr. Barrientos (R) in El Salvador and Dr. Chetty in South Africa (R).

Each protocol varies the intensity and classes of drugs based on style and phase of illness. As a general rule, day 1-3 is the golden window for initiation of early treatment, 4-6 agents are required, and the duration of therapy can be as short as 5 and as long as 30 days depending on the circumstances.[R

Dr. Peter McCullough, is recovered well after being diagnosed with coronavirus in October 2020. The 57-year-old physician used the protocol of hydroxychloroquine, antibiotics, aspirin, and vitamins that he and over 20 of his colleagues have published for the early treatment of COVID-19.

After eight days, he felt well enough to go for a jog.

“It’s a rough illness and I can see why older adults are worried,” McCullough recounted his experience to The Texan. “I am strongly encouraging early home treatment for anyone over 50 of who has underlying health conditions.”

For patients who are over 50 and/or have health risks such as underlying lung, heart, or kidney disease, diabetes, cancer, or obesity, McCullough urges treatment at the onset of symptoms of coronavirus to get ahead of the virus and prevent hospitalization.

As one example, McCullough successfully treated his elderly father, a nursing home resident, when he contracted coronavirus earlier this year. His father did not require hospitalization.

“The vaccination will be too late to save so many Americans,” McCullough emphasized.

McCullough, who is widely published and works with two well-known Texas medical institutions, first issued his suggested protocol in the American Journal of Medicine in August 2020.

Since the time of the original publication in The American Journal of Medicine, Dr Peter McCullough and colleagues have updated the treatment algorithm to include bamlanivimab, casirivimab and imdevimab, and ivermectin (The Reply - The American Journal of Medicine).

The vitamin and supplement protocol includes: quercetin, zinc sulfate, Vitamin D3, and Vitamin C. McCullough said he doesn’t have any evidence to believe these help prevent contracting the illness, but he believes they should be included in the early treatment protocol as supportive therapies.

Because the virus replicates rapidly, McCullough recommends using a course of 200 milligrams (mg) of hydroxychloroquine twice a day for at least five days. Of all the therapies he used, McCullough believed this helped him the most during his illness.

“Hydroxychloroquine far and away made the biggest difference,” McCullough commented. “It is not a cure alone, but it makes a giant difference.”

If a patient has known heart issues that put them at risk when taking hydroxychloroquine, McCullough offers ivermectin as an alternative.

He also believes the United States needs to immediately investigate the efficacy of favipiravir, which he says is being used successfully as a treatment in 30 countries around the world.

Along with hydroxychloroquine, McCullough’s protocol suggests a course of antibiotics, such as doxycycline or azithromycin, to help reduce the chance of secondary infections.

The risk of blood clotting is one of the most frightening aspects of the disease, McCullough acknowledged, and thus he has updated his earlier advice to increase the recommended dosage of aspirin to 325 mg daily.

For those who contract COVID-19 and are in the “at-risk” category, McCullough recommends “A Guide to Home-Based COVID Treatment” published by the Association of American Physicians and Surgeons (AAPS).  

If the patient’s physician is unsure about or unwilling to use the treatment protocol, the AAPS guide has suggested telemedicine options for receiving treatment.

McCullough believes that the treatment program he recommends is reasonable for the whole country.

“In a pandemic, we have to make a decision based on a reasonable chance of success,” he remarked. “We need major medical centers and medical boards to get on board [with early treatment].”

“I never thought I’d see the day where doctors are censored, and patients are kept from care,” McCullough grieved.

Because the virus continues to spread despite control measures, McCullough believes hospitals could soon be overrun unnecessarily. The National Institutes of Health COVID-19 treatment plan makes no recommendations for treatment until a patient is hospitalized and in need of oxygen, McCullough pointed out.

However, he sees this as a recipe for disaster as hospitals are not equipped to be the first line of treatment.

Since posting his first videos in October, McCullough says they have had thousands of views, and he has given multiple interviews with medical reporters.

Early Treatment Guidelines Have Saved Millions of Lives

In December 2020, McCullough published an updated protocol, co-written with 56 other authors who also had extensive experience with treating COVID-19 outpatients. The article, "Multifaceted Highly Targeted Sequential Multidrug Treatment of Early Ambulatory High-Risk SARS-CoV-2 Infection," was published in the journal Reviews in Cardiovascular Medicine, of which McCullough is the editor-in-chief.

Dr McCullough has also updated his protocol to incorporate ivermectin as an option for early treatment protocol as published in the journal above.

"That paper, today … is the most frequently downloaded paper from BET Journal," McCullough says. "It also is the basis for the American Association of Physician and Surgeons COVID early treatment guide. (Download Guide - Feb 2, 2022 version)

We have evidence that the treatment guide has been downloaded and utilized millions of times. And it was part of the early huge kick that we had in ambulatory treatment at home towards the end of December into January, which basically crushed the U.S. curve.

We were on schedule to have 1.7 to 2.1 million fatalities in the United States, as estimated by the CDC and others. We cut it off at about 600,000. That still is a tragedy. I've testified that 85% of that 600,000 could have been saved if we would have had … the protocols in place from the start.

But suffice it to say, the early treatment heroes, and you're part of that team Dr. Mercola, has really made the biggest impact. We have saved millions of lives, spared millions and millions of hospitalizations, and in a sense, have brought the pandemic now to a winnowing close."

While the World Health Organization and national health agencies have all rejected treatments suggested by doctors for lack of large-scale randomized controlled studies, McCullough and other doctors working the frontlines took an empiric approach. They looked for signals of benefit in the literature.

"We didn't demand large randomized trials because we knew they weren't going to be available for years in the future," McCullough says. "We didn't wait for a guidelines body to tell us what to do or some medical society, because we know they work in slow motion. We knew we had to take care of patients now."

Dr. McCullough qualified that these views expressed are his own and do not necessarily reflect those of the institutions he’s associated with.

Dr Peter McCullough Senate Hearing


How Can I Reach Dr Peter McCullough?

E-mail: PeterAMcCullough@gmail.com

rumble.com/petermcculloughmd (Dr Peter McCullough Website)

twitter.com/P_McCulloughMD (Twitter)

Freedom, Health, Health Freedom Defense Fund stands by Dr. Peter McCullough: https://healthfreedomdefense.org/2021/08/health-freedom-defense-fund-stands-by-dr-peter-mccullough/

Dr Peter McCullough SubStack: https://petermcculloughmd.substack.com/

Hydroxychloroquine and COVID-19

Hydroxychloroquine (HCQ) is not effective when used very late with high dosages over a long period (RECOVERY/SOLIDARITY), effectiveness improves with earlier usage and improved dosing. Early treatment consistently shows positive effects. Negative evaluations typically ignore treatment time, often focusing on a subset of late stage studies.

As of March 2023, there are more than 350 published evidence of hydroxychloroquine for COVID-19 (c19hcq.org).

Do you need a prescription for hydroxychloroquine?

Yes, hydroxychloroquine is a prescription drug and you do need it to be prescribed to you by a doctor.

McCullough Early Treatment Protocol (Summary)

McCullough Protocol 2022
McCullough Protocol 2022

Note and Update: Omicron variant XBB found to be resistant to monoclonal antibody treatments (New England Journal of Medicine. Dec 2022)

McCullough Protocol for Low Risk Patients (Healthy) - Dr Peter McCullough Protocol Vitamins

  1. Vitamin D3 5000 iu 1 time a day for 5 - 30 days (Amazon)
  2. Zinc Sulfate 220mg 1 time a day for 5 - 30 days (Amazon)
  3. Quercetin 500 mg 2 times a day for 5 - 30 days (Amazon
  4. Vitamin C 3000 mg 1 time a day for 5 - 30 days (Amazon)

McCullough Protocol for Age 50 years and higher or with Single Co-morbidity

Anti-Infective Agents (immediately)
  • Hydroxychloroquine (HCQ) 200mg 2 times a day for 5-30 days (Find a Doctor).
  • Azithromycin (Zithromax) 250 mg 2 times a day for 5-30 days (Find a Doctor).
  • Ivermectin: 6 - 24 mg (take with or after meals) — one dose daily, take for 1 - 5 days. (Find a Doctor). Use upper dose range if:  1) in regions with more aggressive variants; 2) treatment started on or after day 5 of symptoms or in pulmonary phase; or 3) multiple comorbidities/risk factors. (Ref)
  • Azithromycin (Zithromax) 250 mg 2 times a day for 5-30 days (Find a Doctor).
Single Comorbidity: More than 30 kg/m2, lung disease, diabetes mellitus, cardio-vascular disease, chronic kidney disease, cancer

If respiratory symptoms develop or Day 5 of Illness
  • Dexamethasone 6 mg 1 time a day for 7 days OR Prednisone 1 mg/kg once a day for 5 days, taper as needed (not suitable during viral phase)
  • Budesonide 1mg/2cc solution via nebulizer twice a day for 7 days (not suitable during viral phase)
Suspect micro blood clots
  • Aspirin 325 mg once a day (5 - 30 days)
The above protocol for 50 years and above, and with single comorbidity are recommended in combination with the nutraceuticals as recommended for healthy patients i.e. vitamin D3, quercetin, zinc and vitamin C.

Editor's Notes:
  • Inorganic zinc such as zinc sulfate, is not as effective or useable by your body as chelated zinc sources. Zinc lozenges are preferred so that the tissues of the nose and throat are rich in zinc as soon as they encounter the virus.
  • COVID-19 is a highly dynamic topic. Please refer to the latest FLCCC I-MASK+ protocol.


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