12 Natural Alternatives to Oral Ivermectin (2023) - Evidence based Review
- Most of the studies on ivermectin are small and are of low quality?
- Ivermectin is for horses and dogs?
- We shall wait for bigger and better quality evidence before we can make formal recommendations? There’s no evidence that IVM works or the effectiveness is yet to be proven?
- There are no randomized controlled trials of IVM?
In a nutshell, there are two conflicting recommendations from various professional groups. One for and the other against.
The past two years saw basic health information censored and slapped with "mis/dis/mal/information" labels amid a pandemic. 'Misinformation' is based on inaccurate facts. So, what are accurate and inaccurate facts? That will depend on science and research. However, science and research can be manipulated and is subjected to bias. Therefore, it is wise to do your own research in consultation with your trusted doctor. Unfortunately, some of the references used by many media channels are based on outdated studies, or a biased selection of studies based on the narrative that they would like to support.According to the The Cochrane Review’s editor-in-chief, Karla Soares-Weiser:
Natural Alternatives to IvermectinIvermectin is a useful medication against Covid but we don't think it's a miracle drug. There is more than one way to manage COVID-19.
|Nutraceutical Therapy by Mode of Action|
1. Vitamin D3 - Anti-inflammatory and Anti-coagulant
In all cases, the data consistently show that low vitamin D levels raises your risk of COVID while higher baseline levels and/or supplementation lowers all risks by 1.5 to three times.
2. Quercetin - Anti-inflammatory, anti-coagulant, zinc ionophore and anti-viral
3. Zinc - Anti-viral
Improving zinc intake/zinc status improves/modulates/enhances immune function. The flip side is, while some aspects of immunity slow, others increase. Uncontrolled immune responses drive excess inflammation. Zinc helps to balance all of this.
“Zinc is involved in numerous aspects of cellular metabolism. It is required for the catalytic activity of approximately 100 enzymes and it plays a role in immune function, protein synthesis, wound healing, DNA synthesis, and cell division. Zinc also supports normal growth and development during pregnancy, childhood, and adolescence and is required for proper sense of taste and smell.”
The use of zinc for SARS-CoV-2 was a topic routinely flagged by COVID fact checkers as “misinformation,” so word didn’t really get out about its potential as an anti-COVID agent. However, there are more than 35 studies that provided evidence on zinc’s promise for keeping people healthy if they get COVID.
The reason for this is because HCQ is a zinc ionophore (zinc transport molecule), meaning it’s a drug that improves your cells’ uptake of zinc. Once inside your cells, zinc prevents viral replication. This is also why zinc and zinc ionophores need to be taken very early in the illness, or as a prophylactic.
The problem is that zinc is largely insoluble and cannot easily enter through the fatty wall of your cells. Getting all the way into the cell is crucial, as this is where the viral replication occurs. This is why zinc ionophores are so important.
Aside from hydroxychloroquine, other natural, and safer, zinc ionophores include quercetin and epigallocatechin-gallate (EGCG). If given early, zinc along with a zinc ionophore should, at least theoretically, help lower the viral load and prevent the immune system from becoming overloaded.
Excessive doses may interfere with copper absorption, which could negatively affect your immune system as it can cause copper deficiencies, blood disorders and potentially permanent nerve damage. Zinc can also impair the absorption of antibiotics, and use of zinc nasal gels or swabs has been linked to temporary or permanent loss of smell.
“In one study, 300mg/day of zinc as two divided doses of 150 mg zinc sulfate decreased important markers of immune function, such as the ability of immune cells known as polymorphonuclear leukocytes to migrate toward and consume bacteria.
The most concerning effect in the context of COVID-19 is that it lowered the lymphocyte stimulation index 3 fold. This is a measure of the ability of T cells to increase their numbers in response to a perceived threat. The reason this is so concerning in the context of COVID-19 is that poor outcomes are associated with low lymphocytes …
The negative effect on lymphocyte proliferation found with 300 mg/day and the apparent safety in this regard of 150 mg/d suggests that the potential for hurting the immune system may begin somewhere between 150-300 mg/d …
It is quite possible that the harmful effect of 300 mg/d zinc on the lymphocyte stimulation index is mediated mostly or completely by induction of copper deficiency …
The negative effect of zinc on copper status has been shown with as little as 60 mg/d zinc. This intake lowers the activity of superoxide dismutase, an enzyme important to antioxidant defense and immune function that depends both on zinc and copper …
A study done with relatively low intakes of zinc suggested that acceptable ratios of zinc to copper range from 2:1 to 15:1 in favor of zinc. Copper appears safe to consume up to a maximum of 10 mg/d.
Notably, the maximum amount of zinc one could consume while staying in the acceptable range of zinc-to-copper ratios and also staying within the upper limit for copper is 150 mg/d.”
4. Nigella Sativa (Black Seed Oil) and Cytokine Storm - Anti-inflammatoryNigella sativa (N. sativa) is a small flowering plant that grows in Southwest Asia, the Middle East, and Southern Europe (Source). This shrub produces fruit with tiny black seeds. Commonly referred to as black seed, N. sativa seeds go by many other names, such as black cumin, black caraway, nigella, fennel flower, and Roman coriander (Source).
Black seed oil is extracted from N. sativa seeds and has been used in traditional medicine for over 2,000 years due to its many therapeutic benefits.
5. Melatonin- Anti-inflammatory and anti-viral
Check out the evidence tracker on melatonin and COVID-19 from c19melatonin.com (constantly updated). As of January 2023, there are more than 15 published clinical studies of melatonin for treatment and prevention in COVID-19 and the results are promising even when it's given as a late treatment.
Studies have not evaluated melatonin supplementation during pregnancy and breastfeeding, but some research suggests that these supplements might inhibit ovarian function (Source). Therefore, some experts recommend that women who are pregnant or breastfeeding avoid taking melatonin.
6. Vitamin A
Based on this early treatment mortality studies drug league table below, vitamin A might even out-perform vitamin D, ivermectin and hydroxychloroquine:
7. Curcumin and Turmeric - Anti-inflammatory and anti-viral
Curcumin, a yellow carotenoid from turmeric, is a nutritional
therapeutic recommended as part of the FLCCC I-CARE early treatment
protocol, and has antiviral, anti-inflammatory, antioxidant and
immune modulating properties.
There are more than 20 completed studies of curcumin in COVID-19 that suggest that it improves clinical
outcome of patients.
Curcumin also acts as natural zinc ionophores and can promote the
cellular uptake of zinc and can be used with zinc to increase the
effectiveness of these compounds in the inhibition of the virus (Ref).
Curcumin has been demonstrated (Ref) to suppress several inflammatory cytokines and mediators of their
release such as tumor necrosis factor-alpha (TNF-alpha), IL-1, IL-8
and nitric oxide synthase.
8. Vitamin C - Anti-inflammatoryVitamin C, which most of us reach for with any cold or flu, was used in high doses to great effect by COVID-19 early treatment doctors.
Be aware that there are side effects and risks associated with taking high doses of vitamin C. People sometimes assume there is no harm in taking large doses because vitamin C is water-soluble (i.e. excess vitamin C is excreted from the body), but this is not the case. In addition to causing gastric distress and diarrhea, high doses of vitamin C (over 500 mg per day) over the long-term may increase the risk of cataracts. High-dose vitamin C can also reduce the effectiveness of certain medications and interfere with certain blood tests. Furthermore, very high-dose vitamin C (typically 2,000 mg per day or more) can increase the risk of oxalate nephropathy — a condition in which oxalate crystals are deposited in the kidney, leading to kidney damage and/or kidney failure. Cases of this were shown to rise during the first two years of the COVID-19 pandemic, likely due to increased use of very high dose vitamin C (Fong, Kidney Int Rep 2022).
That said, temporarily taking megadoses of vitamin C supplements to combat a case of the cold or flu is likely not going to cause a problem.
9. NAC, Glutathione and COVID-19 - Anti-inflammatory and anti-coagulant
Much of the research on NAC has used an inhaled, liquid form of this compound. This form—which is classified as a drug, not a dietary supplement—is approved by the U.S. Food and Drug Administration (FDA) as a mucolytic agent and for decreasing respiratory secretion viscosity (Source). Products containing NAC are also sold as dietary supplements.
Consider taking around 500 milligrams/day of NAC, as it helps prevent blood clots and is a precursor for your body to produce the important antioxidant glutathione.
10. Probiotics and COVID-19 - Anti-inflammatory
You can find a list of more than 20 published clinical studies on probiotics and COVID-19 from c19probiotics.com (constantly updated). However, with an overall improvement of 25% for all studies, the improvement rate is not as impressive as the other natural alternatives i.e. quercetin, black seed oil and vitamin A, based on the aggregated analysis on C19early.org. However, the improvement rate of 61% (based on 8 studies) has made probiotics ranked No. 6 in the COVID-19 all mortality (death rate) studies league table, better than ivermectin and quercetin.
11. B Vitamins and COVID-19 - Anti-inflammatory
It follows that anything that improves immune system function and decreases the chances that an infected person will have a catastrophic cytokine storm may improve the outcome of COVID-19 cases and decrease the overall death rate. Therefore, it’s quite feasible that B-vitamin supplementation could contribute to preventing the worst COVID outcomes.”
12. Nattokinase - Anti Coagulant
Quercetin, Vitamin C, D, Zinc, Melatonin and the FLCCC Protocol
Eliminate Seed OilsEliminate vegetable (seed) oils in your diet, which involves eliminating nearly all processed foods and most meals in restaurants unless you convince the chef to only cook with butter. Avoid any sauces or salad dressings in restaurants as they are loaded with seed oils. Also avoid chicken and pork as they are very high in linoleic acid, the omega-6 fat that is far too high in nearly everyone and contributes to oxidative stress that causes heart disease.
Metabolic HealthThe ability to eliminate insulin resistance is a strategy that addresses the majority of illnesses that you will ever encounter in your lifetime.
This is why time-restricted eating, eliminating industrially processed seed oils like soy, corn and canola oils, eating a cyclical ketogenic diet, exercising and sleeping well can improve, if not eliminate, most conditions that you would need to take medications for.
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