12 Natural Alternatives for Oral Ivermectin (December 2022) - Evidence based Review
- Most of the studies on ivermectin are small and are of low quality?
- Ivermectin is for horses and dogs?
- We shall wait for bigger and better quality evidence before we can make formal recommendations? There’s no evidence that IVM works or the effectiveness is yet to be proven?
- There are no randomized controlled trials of IVM?
In a nutshell, there are two conflicting recommendations from various professional groups. One for and the other against.
The past two years saw basic health information censored and slapped with "mis/dis/mal/information" labels amid a pandemic. 'Misinformation' is based on inaccurate facts. So, what are accurate and inaccurate facts? That will depend on science and research. However, science and research can be manipulated and is subjected to bias. Therefore, it is wise to do your own research in consultation with your trusted doctor. Unfortunately, some of the references used by many media channels are based on outdated studies, or a biased selection of studies based on the narrative that they would like to support.
Natural Alternatives to IvermectinIvermectin is a useful medication against Covid but we don't think it's a miracle drug. There is more than one way to manage COVID-19.
|Nutraceutical Therapy by Mode of Action|
1. Vitamin D3 - Anti-inflammatory and Anti-coagulant
In all cases, the data consistently show that low vitamin D levels raises your risk of COVID while higher baseline levels and/or supplementation lowers all risks by 1.5 to three times.
“Each 10 ng/mL increase in vitamin D levels was associated with a 45 % and 26 % lower risk of 45-day mortality (HR: 0.55, 95 % CI: 0.40–0.74) and ICU mortality due to COVID-19 (HR: 0.74, 95 % CI: 0.60–0.92), respectively.”
Almost all studies consider a vitamin D blood serum level of >30 ng/mL ‘adequate/good’. Several studies have shown that people with a blood serum level of >50 ng/mL hardly get sick at all. Results of a systematic review and meta-analysis (Nutrients 2021) suggested that COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3.
2. Quercetin - Anti-inflammatory, anti-coagulant, zinc ionophore and anti-viral
3. Zinc - Anti-viral
Improving zinc intake/zinc status improves/modulates/enhances immune function. The flip side is, while some aspects of immunity slow, others increase. Uncontrolled immune responses drive excess inflammation. Zinc helps to balance all of this.
“Zinc is involved in numerous aspects of cellular metabolism. It is required for the catalytic activity of approximately 100 enzymes and it plays a role in immune function, protein synthesis, wound healing, DNA synthesis, and cell division. Zinc also supports normal growth and development during pregnancy, childhood, and adolescence and is required for proper sense of taste and smell.”
The use of zinc for SARS-CoV-2 was a topic routinely flagged by COVID fact checkers as “misinformation,” so word didn’t really get out about its potential as an anti-COVID agent. However, there are more than 35 studies that provided evidence on zinc’s promise for keeping people healthy if they get COVID.
The reason for this is because HCQ is a zinc ionophore (zinc transport molecule), meaning it’s a drug that improves your cells’ uptake of zinc. Once inside your cells, zinc prevents viral replication. This is also why zinc and zinc ionophores need to be taken very early in the illness, or as a prophylactic.
The problem is that zinc is largely insoluble and cannot easily enter through the fatty wall of your cells. Getting all the way into the cell is crucial, as this is where the viral replication occurs. This is why zinc ionophores are so important.
Aside from hydroxychloroquine, other natural, and safer, zinc ionophores include quercetin and epigallocatechin-gallate (EGCG). If given early, zinc along with a zinc ionophore should, at least theoretically, help lower the viral load and prevent the immune system from becoming overloaded.
Excessive doses may interfere with copper absorption, which could negatively affect your immune system as it can cause copper deficiencies, blood disorders and potentially permanent nerve damage. Zinc can also impair the absorption of antibiotics, and use of zinc nasal gels or swabs has been linked to temporary or permanent loss of smell.
“In one study, 300mg/day of zinc as two divided doses of 150 mg zinc sulfate decreased important markers of immune function, such as the ability of immune cells known as polymorphonuclear leukocytes to migrate toward and consume bacteria.
The most concerning effect in the context of COVID-19 is that it lowered the lymphocyte stimulation index 3 fold. This is a measure of the ability of T cells to increase their numbers in response to a perceived threat. The reason this is so concerning in the context of COVID-19 is that poor outcomes are associated with low lymphocytes …
The negative effect on lymphocyte proliferation found with 300 mg/day and the apparent safety in this regard of 150 mg/d suggests that the potential for hurting the immune system may begin somewhere between 150-300 mg/d …
It is quite possible that the harmful effect of 300 mg/d zinc on the lymphocyte stimulation index is mediated mostly or completely by induction of copper deficiency …
The negative effect of zinc on copper status has been shown with as little as 60 mg/d zinc. This intake lowers the activity of superoxide dismutase, an enzyme important to antioxidant defense and immune function that depends both on zinc and copper …
A study done with relatively low intakes of zinc suggested that acceptable ratios of zinc to copper range from 2:1 to 15:1 in favor of zinc. Copper appears safe to consume up to a maximum of 10 mg/d.
Notably, the maximum amount of zinc one could consume while staying in the acceptable range of zinc-to-copper ratios and also staying within the upper limit for copper is 150 mg/d.”
4. Nigella Sativa (Black Seed Oil) and Cytokine Storm - Anti-inflammatoryNigella sativa (N. sativa) is a small flowering plant that grows in Southwest Asia, the Middle East, and Southern Europe (Source). This shrub produces fruit with tiny black seeds. Commonly referred to as black seed, N. sativa seeds go by many other names, such as black cumin, black caraway, nigella, fennel flower, and Roman coriander (Source).
Black seed oil is extracted from N. sativa seeds and has been used in traditional medicine for over 2,000 years due to its many therapeutic benefits.
5. Melatonin- Anti-inflammatory and anti-viral
Check out the evidence tracker on melatonin and COVID-19 from c19melatonin.com (constantly updated).
Studies have not evaluated melatonin supplementation during pregnancy and breastfeeding, but some research suggests that these supplements might inhibit ovarian function (Source). Therefore, some experts recommend that women who are pregnant or breastfeeding avoid taking melatonin.
6. Vitamin A
Based on this early treatment mortality studies drug league table below, vitamin A might even out-perform vitamin D, ivermectin and hydroxychloroquine:
7. Curcumin and Turmeric - Anti-inflammatory and anti-viral
Curcumin, a yellow carotenoid from turmeric, is a nutritional
therapeutic recommended as part of the FLCCC I-CARE early
treatment protocol, and has antiviral, anti-inflammatory,
antioxidant and immune modulating properties.
There are more than 20 completed studies of curcumin in COVID-19 that suggest that it improves
clinical outcome of patients.
Curcumin also acts as natural zinc ionophores and can promote
the cellular uptake of zinc and can be used with zinc to
increase the effectiveness of these compounds in the inhibition
of the virus (Ref).
Curcumin has been demonstrated (Ref) to suppress several inflammatory cytokines and mediators of
their release such as tumor necrosis factor-alpha (TNF-alpha),
IL-1, IL-8 and nitric oxide synthase.
8. Vitamin C - Anti-inflammatory
Vitamin C, which most of us reach for with any cold or flu, was
used in high doses to great effect by COVID-19 early treatment
Vitamin C may be one of the most well-known immune
nutrients that protect against immune deficiencies and which
supports the prevention and recovery from the common cold and
upper-respiratory issues, and also protects your cardiovascular
system, eyes, skin, and other parts of your body. Research has
found that vitamin C may help to optimize the immune system.
Do take note that the vitamin C dosages given in the hospitals
intravenously are different from those over the counter vitamin
C supplements. Therefore, when you come across studies on
vitamin C, you need to differentiate those that are given
intravenously vs oral vitamin C.
Vitamin C and COVID-19
Check out the evidence tracker on vitamin C and COVID-19
from c19vitaminc.com (constantly updated).
Safety: The U.S. Recommended Dietary Allowance
(RDA) for vitamin C is 75 to 120 milligrams per day. Taking
large doses of vitamin C (ascorbic acid) on a regular basis
lowers your level of copper, so if you are already deficient
in copper and take high doses of vitamin C, you can compromise
your immune system.
While generally considered safe even in high doses, way too
much vitamin C — anything above 2,000 milligrams daily—can
cause headaches, insomnia, diarrhea, heartburn, and other
Temporarily taking megadoses of vitamin C supplements to
combat a case of the cold or flu is likely not going to cause
Many vitamin C supplements that are above the US RDA are sold in
the market. It’s important to seek a physician’s advice if you
intend to take high dose vitamin C on a long term basis. To be
on the safe side, you may also request for your kidney functions
to be monitored.
For long-term, daily use, your best bet is to eat a diet that is
full of high quality organic vegetables and fruits that are
minimally processed. Not only will you get vitamin C, but you
will get all the other accessory nutrients and micronutrients
that are needed to optimize it.
Vitamin C, Omicron and Deltacron
Will Vitamin C Work Against Omicron or Deltracron? Vitamin C
is not variant specific because it's primary mode of action is
to support the body’s immune system which reacts in a variety
of ways against viral attack, not just in a specific antibody
reaction to a specific spike protein.
Related: Best Vitamin C Supplement
Temporarily taking megadoses of vitamin C supplements to combat a case of the cold or flu is likely not going to cause a problem.
9. NAC, Glutathione and COVID-19 - Anti-inflammatory and anti-coagulant
Much of the research on NAC has used an inhaled, liquid form of this compound. This form—which is classified as a drug, not a dietary supplement—is approved by the U.S. Food and Drug Administration (FDA) as a mucolytic agent and for decreasing respiratory secretion viscosity (Source). Products containing NAC are also sold as dietary supplements.
Consider taking around 500 milligrams/day of NAC, as it helps prevent blood clots and is a precursor for your body to produce the important antioxidant glutathione.
10. B Vitamins and COVID-19 - Anti-inflammatory
It follows that anything that improves immune system function and decreases the chances that an infected person will have a catastrophic cytokine storm may improve the outcome of COVID-19 cases and decrease the overall death rate. Therefore, it’s quite feasible that B-vitamin supplementation could contribute to preventing the worst COVID outcomes.”
11. Probiotics and COVID-19 - Anti-inflammatory
You can find a list of 15 published clinical studies (7 RCTs) on probiotics and COVID-19 from c19probiotics.com (constantly updated).
12. Lactoferrin - Anti-viral
Lactoferrin may slow pathogen multiplication through its iron binding capacity. While iron is required for DNA replication and energy production, the presence of excess iron increases free radical generation, stimulates inflammatory processes, and exacerbates viral infection by promoting increased viral replication (Ref). Furthermore, patients with a severe acute viral respiratory infection have been found to have elevated levels of ferritin, and these levels correlated with increased risk of death (Ref). In its iron-free state (apolactoferrin), lactoferrin can sequester pro-oxidant free iron, lowering oxidative stress and suppressing the growth of pathogens, and possibly mitigating the serious complications of infection (Ref).
Quercetin, Vitamin C, D, Zinc, Melatonin and the FLCCC Protocol
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Eliminate Seed OilsEliminate vegetable (seed) oils in your diet, which involves eliminating nearly all processed foods and most meals in restaurants unless you convince the chef to only cook with butter. Avoid any sauces or salad dressings in restaurants as they are loaded with seed oils. Also avoid chicken and pork as they are very high in linoleic acid, the omega-6 fat that is far too high in nearly everyone and contributes to oxidative stress that causes heart disease.
Metabolic HealthThe ability to eliminate insulin resistance is a strategy that addresses the majority of illnesses that you will ever encounter in your lifetime.
This is why time-restricted eating, eliminating industrially processed seed oils like soy, corn and canola oils, eating a cyclical ketogenic diet, exercising and sleeping well can improve, if not eliminate, most conditions that you would need to take medications for.
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