The Aesthetics Advisor

There has been quite a lot of activity in povidone iodine mouthwash space, and so we thought we’d do a round-up and summary on some of the relevant interviews and studies. Dr McCullough's interview with Dr Peter Breggin In this September 14, 2021 interview with Peter Breggin MD, author of Talking Back to Prozac, Dr. Peter McCullough discusses the routine use of diluted (1%) Povidone Iodine mouth wash i n the dental office as an excellent preventive measure for COVID-19.  10% Povidone Iodine is available OTC (Over the Counter) without a prescription at any drug store for a few dollars. Here is the link:   Povidone 10% Iodine on Amazon Note: This 10% Povidone Iodine must be diluted by one tenth, to 1% strength before use as a mouth wash, otherwise it is too strong and irritating. Dilute by adding 2 tablespoons (30 ml) of the 10% Povidone Iodine into a full glass of water (250-300 ml). This will make the product diluted enough to use as a mouth rinse, or gargle, (approximately 1.0 to

Virucidal activity of CPC-containing oral rinses against SARS-CoV-2 variants and are active in the presence of human saliva A team of international scientists has demonstrated the usefulness of cetylpyridinium chloride-containing mouthwashes in inhibiting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and reducing the risk of viral transmission. The study is currently available on the  bioRxiv * preprint server. Cetylpyridinium chloride Mouthwash ( Amazon ) Background Due to the presence of angiotensin-converting enzyme 2 (ACE2) in the oral gingival epithelium and salivary glands, the human oral cavity may act as a reservoir for SARS-CoV-2. The ACE2 present on the host cell membrane acts as the primary entry receptor for SARS-CoV-2. Evidence indicates that the saliva of SARS-CoV-2-infected individuals contains high amounts of viral RNA and that aerosols formed from the saliva can act as a potential vector for viral transmission. S

Povidone iodine (PVP-I) is an antiseptic that has been used for over 150 years. It is already proved that different concentration of PVP-I can deactivate COVID-19 virus.  Povidone Iodine COVID-19 Studies We have compiled a list of povidone iodine COVID-19 studies below: Feb 2021 - Guenezan et al., JAMA Otolaryngol Head Neck Surg., doi: 10.1001/jamaoto.2020.5490 (Peer Reviewed) Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial RCT of PCR+ patients with Ct<=20 with 12 treatment and 12 control patients, concluding that nasopharyngeal decolonization may reduce the carriage of infectious SARS-CoV-2 in adults with mild to moderate COVID-19. All patients but 1 had negative viral titer by day 3 (group not specified). There was no significant difference in viral RNA quantification over time. The mean relative difference in viral titers between baseline and day 1 was 75% [43%-95%] in the intervention

As of January 2022, there are still more than 3,000  clinical trials of COVID-19  treatments or vaccines that are either ongoing or recruiting patients. New ones are being added every day. The drugs or treatments being tested range from vaccines, repurposed flu treatments to failed ebola drugs, to stem cell therapy, to malaria treatments that were first developed decades ago. We know that while a large percentage of the population only experiences mild to moderate symptoms of COVID-19 and won’t require hospitalization, others experience severe symptoms and complications, require hospitalization, or may even die.  NAC weakens the binding of spike protein with ACE2 receptor It appears one of the differences between those who have a mild illness and severe illness is related to the body's ability to reduce the hyperimmune response that leads to a cytokine storm and the hypercoagulability (tendency for blood clots) that often accompanies it.  Image credit: ClevelandClinic             I

Zinc is a well known supplement that is generally contained in standard multivitamins. It provides immune support amongst other functions. Zinc inhibits coronavirus replication and is a general stimulant of antiviral immunity ( source ). Higher levels of intracellular zinc showed to increase intracellular pH; which affect on RNA-dependent RNA polymerase and decreases the replication mechanism of RNA viruses (e.g. COVID-19). Therefore, zinc ionophores (e.g. Quercetin) can likely be used with zinc supplement to act as antiviral against many RNA viruses including influenza and COVID-19. Suggested benefits of zinc supplementation along with zinc ionophores to prevent and treat COVID-19 and other respiratory tract infections are supported by countless studies ( source ). In most cases, prophylactic and early use of zinc supplementation was more effective than late therapeutic proceedings. Up to 30% of the everyday respiratory infections, briefly named “common cold,” are due to infections w

Information related to the COVID-19 ('CO' stands for corona, 'VI' for virus, and 'D' for disease) pandemic has been overwhelming and confusing as well. The information is all over the place and various groups are giving conflicting statements. How do you make sense from all these fragmented information? As of August 2021, there are more than 6,000 studies that have been launched to investigate various treatments for COVID-19. You can review the details of these trials on  ClinicalTrials.gov . New ones are being added every day. The aim of this article is to organise and summarise relevant information in one place. Below, we look at the most studied categories.         McCullough et al. Reviews in Cardiovascular Medicine, 2020 Most doctors know the need to focus now on early treatment as the most immediate and practical way to reduce hospitalisations and death. This is your guide to help you know your options, and to use with your personal physician. Below, we lo