The Aesthetics Advisor

In a series of articles, biohacker Georgi Dinkov highlights a variety of benefits of niacinamide (aka nicotinamide), a form of niacin (vitamin B3) that plays a vital role in energy metabolism, as it’s essential for the mitochondrial electron transport chain to function. Without it, your mitochondria cannot make energy. Niacinamide is so important because it is a precursor for NAD+ , which is involved in the conversion of food to energy, maintaining DNA integrity and ensuring proper cell function. NAD+ is also a primary fuel for sirtuins, longevity proteins that become depleted with age. As such, niacinamide can be an important longevity hack. As I’ve explained in previous articles, niacinamide at a dose of 50 milligrams per day will provide the fuel for NAMPT, the rate limiting enzyme for NAD+. Niacinamide also has potent antiobesity effects, can help prevent neurodegeneration and heart failure, and reverse leaky gut. Obesity Epidemic Linked to Decline in Basic Metabolic Rate In a May ...

Immune system weakening has long been attributed to aging and poor lifestyle choices, but according to an October 2023 study 1   in Nature Communications, the key reason for this immune system decline is dysfunctional mitochondria, your cells' powerhouses, particularly the mitochondria found in T cells (a type of immune cell). When the mitochondria don't work well, the T cells don’t have the energy required to perform their functions, which leads to a decline in immune system function. This in turn, results in an inability to ward off both acute infections and chronic diseases. As reported by Medical Xpress (2): “... In the immune system, chronic infections and the defense against tumors often lead to the phenomenon of T cell exhaustion: In this process, the T lymphocytes gradually lose their function, which impairs their responses against cancer and infections ... This research has now shown that the exhaustion process is significantly influenced by ... the mitochondria. When ...

I recently posted   an article detailing the importance of niacinamide   (aka, nicotinamide, a form of vitamin B3 or niacin) for healthy mitochondrial function and cellular energy production, and how it can help reverse obesity and leaky gut, and prevent neurodegeneration, kidney disease and heart failure. Here, I’ll review several additional conditions that can be prevented and/or treated with this inexpensive and readily available supplement. More Niacinamide Is NOT Better, There’s a Goldilocks’ Dose Keep in mind that the dosages used in the research studies discussed below do vary widely, but as a rule, I only recommend taking small doses of 50 milligrams of niacinamide three times a day. This dosage has been shown to optimize energy metabolism and boost NAD+ levels, which are foundational for everything else to work. It can be taken four times a day if you space them out. Take a dose as soon as you get up, before going to bed, and twice evenly spaced between those times. T...