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Ivermectin and Fenbendazole in the Treatment of Psoriasis? A Case Series of 13 Patients (2026)

By Dr Frank Yap, MD
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Abstract Psoriasis is a chronic autoimmune condition affecting approximately 7.5 million individuals in the United States, with significant economic, physical, and psychological burdens. This case series reports on 13 patients who experienced notable improvements in psoriasis symptoms following treatment with ivermectin and/or fenbendazole, antiparasitic agents repurposed for this indication. Cases were derived from self-reported testimonials shared on social media platforms. Treatment durations ranged from 3 days to 3 months, with dosages varying between 6 mg ivermectin twice daily and combinations with fenbendazole. Rapid resolution of skin lesions was observed in most cases, with some achieving near-complete clearance. While these anecdotal reports suggest potential therapeutic efficacy, controlled clinical trials are warranted to validate these findings and elucidate underlying mechanisms. Introduction Psoriasis is a chronic inflammatory disorder characterized by hyperproliferation...
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Best Vitamin D3 + K2 Supplements in 2026: Doctor-Reviewed Picks for Bone, Heart & Immune Health

By Dr Frank Yap, MD
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Vitamin D3 and Vitamin K2 are two of the most commonly deficient—and misunderstood—nutrients today. While Vitamin D improves calcium absorption, Vitamin K2 determines where that calcium actually goes . That’s why taking Vitamin D without K2 may be incomplete—and in some cases counterproductive. After reviewing ingredient quality, dosing accuracy, brand transparency, and real-world user feedback, the following are the best Vitamin D3 + K2 supplements available in 2026 . Most people in the United States consume less than recommended amounts of vitamin D . An analysis of data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 4.3 mcg in men, 3.8 mcg in women, and 5 mcg (200 IU) in children aged 2–19 years ( NHANES 2017 - 2018 ). Why Trust This Guide? This review prioritizes supplements that meet four non-negotiable criteria : Uses Vitamin D3 (cholecalciferol) — not D2 Includes Vitam...
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7 Best Cetylpyridinium Chloride Mouthwash Brands 2025

By Dr Frank Yap, MD
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A meta-analysis of 3 studies (C19early 2025) concluded that CPC (CetylPyridinium Chloride) may significantly lower risk with  viral clearance . One study shows significant benefit. Meta analysis using the most serious outcome reported shows 83% [6‑97%] lower risk . Results are consistent with early treatment being more effective than late treatment. A study, published in Nature ( Takeda 2022 ) concluded that CPC (CetylPyridinium Chloride) may inhibit SARS-CoV-2 infection even at lower concentrations. Another team of international scientists has also demonstrated the usefulness of cetylpyridinium chloride-containing mouthwashes in inhibiting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and reducing the risk of viral transmission. The study is published in the Journal of Medical Microbiology (2022). A scientific review, published in the  Journal of Formosan Medical Association  (2022) also concluded that mouthwash containing CPC shows potential fo...
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7 Best Organic Vitamin D3 and K2 Supplements 2025

By Dr Frank Yap, MD
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In recent weeks and months, several publications and studies have suggested that maintaining adequate levels of vitamin D would seem potentially beneficial in fighting the COVID-19 infection. How do you know that your vitamin D level is adequate? Most people in the United States consume less than recommended amounts of vitamin D. An analysis of data from the 2015–2016 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 5.1 mcg (204 IU) in men, 4.2 mcg (168 IU) in women, and 4.9 mcg (196 IU) in children aged 2–19 years ( NHANES ). What Is Vitamin D? Vitamin D is a fat-soluble vitamin, meaning that it dissolves in fats and oils and can be stored in your body for a long time. Vitamin D is important to the body in many ways. It helps the body absorb calcium from food and supplements. Muscles need it to move, for example, nerves need it to carry messages between the brain and every body part, and the immune syste...
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17 Best Natural Ozempic Alternatives 2025 (Resource Guide)

By Dr Frank Yap, MD
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Some of the best natural alternatives to Ozempic include berberine, a supplement that has shown potential in managing blood sugar and promoting weight loss, often referred to as “nature’s Ozempic” in wellness communities. High-fiber foods also play a crucial role by helping to control appetite and improve metabolic health. Other natural options include psyllium husk, which provides soluble fiber supporting satiety and digestive health, and curcumin, known for its anti-inflammatory properties, which may aid metabolic balance. Additionally, green tea extract, magnesium, protein-rich foods, and lifestyle factors like adequate sleep and stress reduction contribute to weight management.  However, none of these natural alternatives are as potent or fast-acting as Ozempic itself, and their effects can vary widely among individuals. It is important to consult a healthcare provider before starting any supplement regimen, especially for managing blood sugar or weight loss. The 2023 rep...
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9 Best Vitamin D3, K2 and Magnesium Supplements 2025

By Dr Frank Yap, MD
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Magnesium, vitamin D and Vitamin K2 are vitamin and minerals that are vital to several bodily processes. Though they occur naturally in a variety of foods, many people take supplements to help increase their intake. Magnesium, Vitamin D3 and Vitamin K Dosage The typical daily dosage recommendations for these nutrients are: Magnesium: 400–500 mg Vitamin D3: 800 IU (20 mcg)  Vitamin K : 120mcg Food With Magnesium, Vitamin D3 and Vitamin K Magnesium: dark chocolate, avocados, nuts, leafy vegetables, and legumes Vitamin D3: avocados, nuts, seeds, full-fat dairy products and eggs Vitamin K: turnips, spinach, kale, brocolli, soybeans, carrots, Chicken If you’re concerned you may be deficient in any of these nutrients, talk to a health professional who can test your levels and determine whether you should eat more of these foods or take a supplement. Benefits and uses 1. May support bone health Magnesium  plays a key role in converting vitamin D into its active form, which aids calci...
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Retatrutide vs Tirzepatide vs Semaglutide (Ozempic): GLP-1 Wars

By Dr Frank Yap, MD
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Introduction The landscape of obesity treatment has evolved dramatically with the introduction of advanced medical therapeutics like retatrutide (RETA, LY3437943), tirzepatide (Mounjaro), and semaglutide (Ozempic). These drugs, originally developed to manage type 2 diabetes, have shown remarkable efficacy in promoting weight loss, making them game-changers for obesity management. However, each drug has unique mechanisms, benefits, and potential applications, including emerging roles in cancer prevention. This article compares retatrutide, tirzepatide, and semaglutide, highlighting their differences in mechanism of action, weight loss efficacy, additional health benefits, and side effects to help patients and healthcare providers make informed decisions. Update: Are GLP-1s the first longevity drugs ? (Nature 2025) Credit: GoodRx Health Mechanism of Action Semaglutide : Semaglutide (Ozempic and Wegovy) is a glucagon-like peptide-1 receptor agonist (GLP-1 RA). It mimics the action of GLP...
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Gut Microbiome May Be a Game Changer for Cancer Prevention

By Dr Frank Yap, MD
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In recent years, it's become increasingly apparent that the composition of microbes in your gut — which is as distinct to you as your fingerprint — plays an enormous role in health and disease prevention. Your gut flora influences the function of various internal organs, such as your skin, lungs, breasts and liver. 1 For example, 2018 research 2  by the National Institute of Health shows gut microbes control antitumor immune responses in the liver, and that antibiotics — by depleting your gut of valuable bacteria — can alter the composition of immune cells in your liver and trigger tumor growth. Aside from cancer, dozens of other health conditions have been traced back to the influence of gut microbes as well, including obesity, depression, chronic fatigue syndrome, Parkinson's and allergies, 3  just to name a few. One of the reasons for this is because your gut is the main residence of your immune system. 4 Disrupt your gut microbiome and you automatically...
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9 Best Anti Aging Skincare Hong Kong 2025

By Dr Frank Yap, MD
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It’s natural to have complex feelings about noticing signs of aging. You can embrace the beauty and privilege that it is to age, while also not love all of the physical changes that come along with it.  If you’d like to soften these signs but don’t want to go the injectables route, there are non-invasive products that can help. In the world of beauty products, there's perhaps no category more saturated than the anti-aging market. What to Look for in an Anti-Aging Product a. Vitamin C An antioxidant powerhouse, vitamin C is directly involved with collagen production in the body. Vitamin C is beneficial in anti-aging products for several reasons: It protects skin from environmental stressors, promotes cell turnover, and can fade dark spots which contribute to the appearance of aging skin. Products containing vitamin C can irritate sensitive skin, so be sure to start out using a low concentration if your skin is reactive. b. Retinoids Retinoids are a category of ingredients, and retin...
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10 Best Nasal Sprays for COVID-19 (2024)

By Dr Frank Yap, MD
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Do nasal sprays actually work against COVID-19? Can I use nasal spray if I have COVID-19?  The COVID-19 pandemic has been roaring on for 3 years. During this time, the FDA has authorized many treatments  that help combat COVID-19. COVID-19 vaccines have also been recommended by the CDC ever since the first ones were authorized in December 2020. However, medications that are already authorized are just a small percentage of what's been studied. Many researchers are still trying to find and develop other medications that can treat or prevent COVID-19. Among these, nasal sprays have caught the attention of many people. They’re often easy to use, and some researchers believe they could have a potential impact on the ongoing pandemic. But are any of them effective at treating or preventing COVID-19? And are any of them close to being available in the U.S.?  Which nasal sprays have been studied to treat or prevent COVID-19? A number of nasal sp...
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