7 Best Cetylpyridinium Chloride Mouthwash Brands

By Dr Frank Yap, MD -
A study, published in Nature (Takeda 2022) concluded that CPC (CetylPyridinium Chloride) may inhibit SARS-CoV-2 infection even at lower concentrations.

Another team of international scientists has also demonstrated the usefulness of cetylpyridinium chloride-containing mouthwashes in inhibiting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and reducing the risk of viral transmission. The study is published in the Journal of Medical Microbiology (2022).

A scientific review, published in the Journal of Formosan Medical Association (2022) also concluded that mouthwash containing CPC shows potential for reducing the viral load of COVID-19 virus in the throat.

Instruction: twice a day or after having been out for prevention, and three times a day for early treatment of COVID-19.


What is Cetylpyridinium Chloride (CPC) Made Of?

Cetylpyridinium chloride (CPC) is obtained by quaternization of pyridine with cetyl chloride


What Does Cetylpyridinium Chloride Do in Mouthwash?

CPC functions by penetrating the cell membrane. This causes cell components to leak, which eventually leads to cell death. It is a well-known antimicrobial agent used in mouthwash to promote gingival health. It has also been used as an antiseptic when treating infections in the mouth and throat.

Cetylpyridinium Chloride Dangers

Cetylpyridinium chloride in mouthwash has been misattributed as a cause of oral cancer in the past, but research has not shown it to link to any form of cancer – no more than any other compound used in mouthwash. The risks of CPC are minor; it is only toxic in large doses (1 gram or more of pure CPC, ingested) and as an antimicrobial spray on food, it is far more helpful than harmful. 

Frequent and heavy use of a CPC-based mouthwash or toothpaste can bring side effects, however. Frequent use of CPC-based oral hygiene products can cause minor brown staining on teeth, a slight burning sensation in the gums and the products have been found to promote the formation of calculus (also known as tartar) on some users' teeth. None of these side effects are particularly harmful, but they should be considered.  

Best Cetylpyridinium Chloride Mouthwash Brands

1. Colgate Total Pro-Shield Alcohol Free Mouthwash


mouthwash with cetylpyridinium chloride cpc

Active Ingredients
Cetylpyridinium Chloride (0.075%). Purpose: Antigingivitis/Antiplaque. Inactive Ingredients: Water, Glycerin, Propylene Glycol, Sorbitol, Poloxamer 407, Flavor, Potassium Sorbate, Citric Acid, Sodium Saccharin, FD&C Blue No. 1.

- Antibacterial Mouthwash Provides 12-Hour Protection Against Germs After Eating and Drinking
- Kills 99% of Germs on Contact
- Significantly Reduces Plaque
- Helps Prevent Gingivitis
- Alcohol Free Mouthwash 
- No Burn of Alcohol (Does Not Contain Ethanol)

2. Crest Scope Outlast Mouthwash

scope mouthwash with cetylpyridinium chloride

Crest Scope Mouthwash Ingredients
Water, alcohol (12.25 wt%), glycerin, polysorbate 80, flavor, sodium saccharin, sodium benzoate, cetylpyridinium chloride, benzoic acid, blue 1.

- Keeps breath feeling fresh up to 5x longer vs. brushing alone
- Speak confidently with the #1 fresh breath brand among non-drug mouthwashes
- P&G Calculation based on Nielsen US reported sales for year ending w/o 1/10/2015
- Crest clean meets Scope freshness
- Kills 99% of bad breath germs in lab tests
- Made in the USAwith U.S. and imported ingredients

3. Colgate Zero with CPC

mouthwash containing cpc

The biggest red flag on an ingredient list for mouthwash is alcohol, according to board-certified dentist Michaela Tozzi, DMD, since it can irritate the gums and oral tissue. Plus, it temporarily depletes saliva flow, which acts as the mouth's immune system. Colgate Zero is alcohol free and contains the anti-viral CPC.

Instructions
Gargle twice a day or after having been out for prevention, and three times a day for early treatment of COVID-19.
  • Active Ingredient: Cetylpyridinium Chloride
  • Kills 99% of plaque germs
  • 0% alcohol
  • 0% dyes
  • 0% artificial flavors
  • 0% artificial sweeteners

4. ACT Dry Mouth Anticavity Mouthwash


mouthwash containing cetylpyridinium chloride

Ingredients
Water, Sorbitol, Poloxamer 407, Propylene Glycol, Menthol, Methyl Salicylate, Sodium Phosphate, Disodium Phosphate, Potassium Sorbate, Polysorbate 20, Sodium Saccharin, Flavor, Cetylpyridinium Chloride, Caldium Disodium Edta, Sodium Benzoate, Green 3, Yellow 5 (309-039)

- Contains one (1) 18 fluid ounce bottle of ACT Anticavity Zero Alcohol Fluoride Mouthwash Mint Flavor
- ZERO ALCOHOL: This ACT Oral Care Product is an alcohol-free mouthwash
- 3 BENEFITS IN 1: This fluoride mouthwash is designed to help prevent cavities, strengthen teeth and freshen breath
- ACCURATE DOSING CUP: Get the right dose of fluoride with the easy-to-use dosing meter
- DENTIST RECOMMENDED BRAND: ACT Fluoride Mouthwash is the #1 dentist recommended fluoride brand*
- FOR AGES 6 & UP: ACT Fluoride Mouthwash is for adults and kids ages 6 and up

5. Crest Pro Health Intense Mouthwash with CPC - Cetylpyridinium Chloride Mouthwash

cetylpyridinium chloride mouth rinse

Active Ingredients
Cetylpyridinium Chloride 0.05% Inactive Ingredients Water, Alcohol (15 Wt%), Propylene Glycol, Flavor, Poloxamer 407, Sucralose, Benzoic Acid, Sodium Benzoate, Blue 1, Yellow 6

- 99% Germ Kill with no medicinal taste
- Cooling sensation
- Keeps teeth clean longer
- Freshens breath
- Fights plaque & gingivitis

6. Scope Mouthwash

scope mouthwash with cetylpyridinium chloride

Ingredients
Cetylpyridinium Chloride (CPC), Water, Alcohol (15 Wt%), Glycerin, Flavor, Polysorbate 80, Sodium Saccharin, Sodium Benzoate, Benzoic Acid, Blue 1, Yellow 5

- Kills 99% of bad breath germs in lab tests
- Crest clean meets Scope freshness
- Cosmetic mouthwash
- Made in the USA with U.S. and imported ingredients
- Original Mint Flavor

7. TheraBreath Healthy Gums Periodontist Formulated 24-Hour Oral Rinse with CPC

Buy on Amazon

A gluten-free, alcohol-free CPC mouthwash option.

TheraBreath Healthy Gums Oral Rinse contains cetylpyridinium chloride (CPC), an ingredient approved by the FDA and clinically proven to kill germs linked to gum disease and other periodontal problems, and adds a sweetener, xylitol (but NO saccharin), to neutralize the decay process.

Amazon Best Sellers Rank: 
#1 in Anesthetic & Antiseptic Oral Rinses
#4 in Mouthwashes

It has over 23,000 customer reviews, most of them 5-stars.


Related: 

Best Mouthwashes for COVID-19 according to Evidence

Beneficial effects of a mouthwash containing an antiviral phthalocyanine derivative (APD) on the length of hospital stay for COVID-19: randomised trial (Nature 2021)

European Union Poised to Ban Toxic Dental Amalgam

This article is part of the Dental Care series. Read More > Dental Care

Comments

Post a Comment

Labels

Show more

Popular posts from this blog

10 Best Vitamin C Serums Recommended by Dermatologists 2025

By Dr Frank Yap, MD -
Image
Vitamin C serum is a serum containing vitamin C that you can apply on your skin. This vitamin is vital for skin growth and repair. It helps with collagen production too. Make up can cover blemishes but the best vitamin C serums can resolve what you’re trying to cover up in the first place! All it takes is a few drops once a day to lighten blemishes, hyper pigmentation, acne scars, the start of wrinkles, dull skin, etc. Vitamin C serum has a wide array of benefits, and most of them are what we have been hoping for our skin. Even skin tone, blur fine lines, remove acne spots, and achieve a natural glow. Among all other skincare ingredients and products marketed these days, Vitamin C is simply the queen of them all. No wonder so many dermatologists and beauty experts rave about incorporating vitamin C into your regime. Related: Best Anti Aging Skincare Hong Kong According to the  Indian Dermatology Online Journal , clinical studies have shown that the topical use of vitamin C increase...
Read more

10 Best Vitamin C Serums for Brighter Skin 2024

By Dr Frank Yap, MD -
Image
Vitamin C is an antioxidant which protects skin cells from damaging free radicals caused by UV exposure. It also helps lighten hyperpigmentation and brown spots, even out skin tone, and enhance skin radiance. Best Vitamin C Serums for Brighter Skin  1. Eva Naturals Skin Clearing Serum Vitamin C+, 30ml Buy on Amazon Ratings : 4.3 out of 5 - more than 57,000 global ratings. Key ingredients: 2% Retinol, 3.5% Niacinamide, 5% Hyaluronic Acid, 2% Salicylic Acid, 10% MSM, 20% Vitamin C. The Derm Review Eva Naturals is a boutique cosmetics company known for its Vitamin C Plus Skin Clearing Serum. This serum is Amazon’s best-selling formula in the facial oil category, with over 16,000 glowing 5-star reviews from customers who have seen impressive results. The serum contains a blend of vitamin C, turmeric, vitamin E, and ferulic acid. It’s designed to combat acne, soothe troubled skin, and reduce blemishes. However, if you have highly sensitive skin prone to acne breakouts...
Read more

9 Best Anti Aging Skincare Hong Kong 2025

By Dr Frank Yap, MD -
Image
It’s natural to have complex feelings about noticing signs of aging. You can embrace the beauty and privilege that it is to age, while also not love all of the physical changes that come along with it.  If you’d like to soften these signs but don’t want to go the injectables route, there are non-invasive products that can help. In the world of beauty products, there's perhaps no category more saturated than the anti-aging market. What to Look for in an Anti-Aging Product a. Vitamin C An antioxidant powerhouse, vitamin C is directly involved with collagen production in the body. Vitamin C is beneficial in anti-aging products for several reasons: It protects skin from environmental stressors, promotes cell turnover, and can fade dark spots which contribute to the appearance of aging skin. Products containing vitamin C can irritate sensitive skin, so be sure to start out using a low concentration if your skin is reactive. b. Retinoids Retinoids are a category of ingredients, and retin...
Read more

10 Best Cosmeceutical Ingredients of 2024

By Dr Frank Yap, MD -
Image
A cosmeceutical is essentially a skincare product that contains a biologically active compound that is thought to have pharmaceutical effects on the skin. Both pharmaceutical and cosmeceutical grade skin care products actively effect skin at a cellular level, whereas cosmetic products have a shorter-term effect. They are usually used by doctors to restore pH, remove pigmentation, or restore the skin barrier. Cosmeceuticals must scientifically verify the claims stated on their packaging; as it is accepted that these formulations are backed by science, clinical studies, and rigorous testing. The main areas of concerns that these formulations address are ageing skin, sensitive/sensitized skin, sun damaged skin, acne/oily skin, loss of tone and elasticity, as well as superficial lines & wrinkles to encourage rapid cellular turnover that will renew and re-texturize the skin. Peptides composed of chains of amino acids give proteins their structure, and transport nutrients and signal mess...
Read more

8 Best Vitamin C Serums for Hyperpigmentation 2024

By Dr Frank Yap, MD -
Image
Vitamin C serums are serums that contain vitamin C which you can apply on your skin. These serums have a wide array of benefits. They help even skin tone, blur fine lines, remove acne spots, and achieve a natural glow. They are also vital for skin growth and repair. They help with collagen production too. Data Bridge Market Research analyses that the global pigmentation disorders treatment market, which was USD 6.5 billion in 2022, would rocket up to USD 12.3 billion by 2030 and is expected to undergo a CAGR (compound annual growth rate) of 7.30 % during the forecast period. Reasons for this growth include increased spending on personal care products and a growing prevalence of skin disorders — many of which are due to global warming. Additional reasons for the worldwide market boost include high disposable income, increasing adoption of smoking in young adults, and growing demand from millennials. How Does Vitamin C Treat Hyperpigmentation? ...
Read more

8 Best Vitamin D3 and K2 Supplements 2025: Benefits, Reviews and Prices

By Dr Frank Yap, MD -
Image
Most people in the United States consume less than recommended amounts of vitamin D . An analysis of data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 4.3 mcg in men, 3.8 mcg in women, and 5 mcg (200 IU) in children aged 2–19 years ( NHANES 2017 - 2018 ). What Is Vitamin D? Vitamin D is a fat-soluble vitamin, meaning that it dissolves in fats and oils and can be stored in your body for a long time. Vitamin D is important to the body in many ways. It helps the body absorb calcium from food and supplements. Muscles need it to move, for example, nerves need it to carry messages between the brain and every body part, and the immune system needs vitamin D to fight off invading bacteria and viruses. Together with calcium, vitamin D also helps protect older adults from osteoporosis. Vitamin D is found in cells throughout the body. Vitamin D Market Size The Global Vitamin D Market size was ...
Read more

Fenbendazole Joe Tippens Protocol: A Step-by-Step Guide

By Dr Frank Yap, MD -
Image
If you have been diagnosed with cancer, or have a loved one that is suffering from cancer, chances are you have heard about the Joe Tippens Cancer Protocol. The Fenbendazole Cancer Protocol has been gaining rapid interest over the past years following some fenbendazole advanced cancer success stories. Joe Tippens founded the protocol after he was told a story about a scientist at Merck Animal Health that had been performing cancer research on mice. The research included injecting different types of cancers into different mice body parts. The scientists discovered, through trial and error, a product in their canine product line, fenbendazole, that was batting 1.000 in killing these different cancers in the mice. The scientist was later diagnosed with stage 4 brain cancer and was given a grim prognosis of only three months to live. She decided to try the fenbendazole, and after six weeks, showed a clean scan. Joe Tippens had been initially diagnosed with small...
Read more

8 Best Eye Creams for Dark Circles Hong Kong 2024

By Dr Frank Yap, MD -
Image
Dark circles is a common cosmetic concerns that can make us look tired, stressed, and older than our actual age. They are distinguished by coloring or pigmentation around the eyes. Many factors, such as genetics, aging, lifestyle choices, underlying medical conditions, and UV exposure, can contribute to the development of dark circles.  There are several home remedies available to reduce the appearance of dark circles, however, it may not be practical for individuals with busy lifestyles since it often requires time and effort to prepare and apply. Therefore, the cream can be the best option! What Causes Dark Undereye Circles? - by Popsugar.co The skin around our eyes is thinner and a lot more delicate, making it more susceptible to external aggressors and damage.  "The eyelids are very vascular, and the eyelid skin is very thin; this will make them more apparent under the eyelid skin and cause the appearance of dark circles," Miss Elizabeth Hawkes, consultant ophthalmic and...
Read more

Biggest Skin-Care Trends of 2024 - Allure

By Dr Frank Yap, MD -
Image
Exosomes, neurocosmetics, and supercharged actives are the most innovative — and sometimes the most controversial — skin-care trends poised to revolutionize beauty in the next few years. We pored over the data and talked with experts to give you a snapshot of the top skin-care trends of 2024. Regenerative medicine will inspire your skin care. This year skin care won’t focus solely on addressing the signs of aging; it’s going to try to make cells behave younger, says Steven Cohen , MD, a board-certified plastic surgeon in San Diego. As with so many skin-care trends that have come before, this one is rooted in medicine — in this case, regenerative medicine, which is centered on developing and applying therapies to help the body heal itself. For example, stem cells — those biological blank slates that can turn into new skin, cartilage, or bone — are currently used in oncology to help the body produce new blood cells after high doses of chemotherapy. Again, this may sound like sci-fi (a t...
Read more

6 Best Organic Vitamin D3 and K2 Supplements 2025

By Dr Frank Yap, MD -
Image
In recent weeks and months, several publications and studies have suggested that maintaining adequate levels of vitamin D would seem potentially beneficial in fighting the COVID-19 infection. How do you know that your vitamin D level is adequate? Most people in the United States consume less than recommended amounts of vitamin D. An analysis of data from the 2015–2016 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 5.1 mcg (204 IU) in men, 4.2 mcg (168 IU) in women, and 4.9 mcg (196 IU) in children aged 2–19 years ( NHANES ). What Is Vitamin D? Vitamin D is a fat-soluble vitamin, meaning that it dissolves in fats and oils and can be stored in your body for a long time. Vitamin D is important to the body in many ways. It helps the body absorb calcium from food and supplements. Muscles need it to move, for example, nerves need it to carry messages between the brain and every body part, and the immune syste...
Read more

Archive

Show more