Cetylpyridinium chloride (CPC) vs Chlorhexidine: What's the Difference?
What is Cetylpyridinium Chloride (CPC)?
CPC functions by penetrating the cell membrane. This causes cell components to leak, which eventually leads to cell death. It is a well-known antimicrobial agent used in mouthwash to promote gingival health. It has also been used as an antiseptic when treating infections in the mouth and throat.
Cetylpyridinium Chloride Dangers
What is Chlorhexidine Gluconate?Chlorhexidine mouthwash has the most ideal properties — antiviral action plus substantivity- to act as an antiviral mouthwash and throat gargle against all enveloped viruses, esp. SARS-CoV-2.
We should use the old and newer lines of evidence and educate the people and help them make use of chlorhexidine mouthwash to eliminate the virus from the oropharyngeal region and reduce the transmission of the virus.
Chlorhexidine gluconate, as a mouthwash and throat gargle, has the ability to work as an effective agent in pre-exposure as well as post-exposure prophylaxis.
Chlorhexidine gluconate will be of great use in clinics to minimize the exposure of healthcare workers to the SARS-CoV-2 virus and safeguard their health.
Along with safe distancing, proper use of masks, hand sanitization, and eyewear, chlorhexidine can reduce virus transmission effectively, safeguard the doctors and clinics, offices, and households from indoor transmission.
It can also help hospitalized patients to reduce their oropharyngeal viral load effectively.
This way, chlorhexidine can help reduce infection as well as infectivity. Thus, it will help us minimize community transmission and control the pandemic crisis.
Cetylpyridinum Chloride vs Chlorhexidine for Dental PlaqueThis study (Periodontol 1996) compared 4 mouthrinse products containing cetylpyridinium chloride (CPC), chlorhexidine, C31G, or triclosan with saline rinse included as a placebo control.
Cetylpyridinum Chloride vs Chlorhexidine for COVID-19A scientific review, published in the Journal of Formosan Medical Association (October 2021) concluded that mouthwash containing CPC shows potential for reducing the viral load of COVID-19 virus in the throat.
Chlorhexidine vs Povidone Iodine vs Colgate Peroxyl vs Listerine?
Results: On testing the different mouthwashes on the viability of cells, all four of them at 100% dilution were highly cytotoxic. The mouthwash least toxic to the cells was Listerine and chlorhexidine gluconate was a close second. On further analysis, when epithelial cells were exposed to the mouthwashes for 2 hours, 6.3% (v/v) diluted Listerine and 1.5% (v/v) diluted chlorhexidine gluconate do not affect the viability of cells. A minimal dilution of 0.1% (v/v) of Colgate Peroxyl or povidone-iodine still showed cytotoxic properties.
On testing the direct effect of mouthwashes on the virus, Colgate Peroxyl and povidone-iodine inactivate COVID-19 more effectively than chlorhexidine gluconate and Listerine. However, their inhibitory effect on the virus is interlinked with cytotoxicity.
This research was important in distinguishing the difference between the antiviral properties of the mouthwash and its cytotoxic properties.