The Hallmarks of Aging’s Original Authors Offer an Updated View (2023)
The year 2023 started with the publication of two remarkable review papers in Cell and Cell Metabolism by researchers addressing the hallmarks of aging and their interplay with the hallmarks of cancer [1,2]. These papers were authored by the same team that published the original 2013 Hallmarks of Aging paper [3]. Much-needed update The original paper on the Hallmarks of Aging systematized the processes underlying aging. As such, it became a very common discussion topic in the rejuvenation world and was frequently cited in research papers related to aging. That paper determined nine hallmarks of aging under three criteria: the process is observed during normal aging, it speeds up aging if worsened, and it reverses some aspects of aging if abolished by therapeutic interventions. Since then, several research groups have proposed the addition of other hallmarks, including five new ones suggested back in August 2022 and cellular enlargement . The authors note that although the originally