10 Most Studied Treatments for COVID 19 (updated June 2023)
As of June 2023, there are more than 9,000 studies that have been launched to investigate various treatments for COVID-19. You can review the details of these trials on ClinicalTrials.gov. New ones are being added every day. The aim of this article is to organise and summarise relevant information in one place. Below, we look at the top 10 most tested and most watched categories.
When interpreting scientific studies, it is important to remember that not all reviews are equally reliable or up to date. If you wish to gain a more comprehensive understanding, it is advisable to conduct a thorough examination of the papers, paying attention to the study dates and the number of studies included. Many reviews and guidelines may rely on outdated studies or fail to consider the full range of relevant research. By delving deeper into the literature, you can obtain a more accurate and comprehensive assessment of the subject matter.
1. Vaccine
This is the most watched category. Technically, vaccine is not
considered a treatment but rather a preventive strategy to boost your
immune system and reduce the risk of getting severe COVID-19.
The Centers for Disease Control and Prevention maintains a list of Covid vaccines that are authorized or approved in the United States.
2. Ivermectin
While this treatment has generated controversy, we have included it in order to acknowledge its popularity and provide a more balanced perspective.
As of June 2023, there are more than 70 on-going trials on Ivermectin registered on ClinicalTrials.gov.
Even with successful vaccines and other preventable measures in
place, the availability of outpatient treatments with solid evidence
has a critical role to play in ending this pandemic.
The use of ivermectin for COVID-19 has been controversial and slapped with 'misinformation'
labels for the past 2 years. Ivermectin is a medication widely
used in low- and middle-income countries to treat parasitic worm
infections in adults and children. It’s been used for decades for
this purpose by over 3.7 billion people, and is considered safe
and effective. It has an increasing list of indications due to its
antiviral and anti-inflammatory properties, and is included on the
WHO’s Model List of Essential Medicines.
Some doctors and media channels argue that there is very little
evidence to support the use of ivermectin to treat COVID-19.
You can find a summary of more than 90 studies on
ivermectin done by more than 800 authors from c19ivermectin.com (constantly updated); in addition, a meta-analysis of all
studies can be found at ivmeta.com (constantly updated). When interpreting meta-analysis or systematic review, note the date of the publication and the no. of RCTs (randomized controlled trials) that are included in the review. As of June 2023, ivermectin has 46 published RCTs.
For adoption and regulatory status of
ivermectin globally, check out "Countries using Ivermectin".
Based on the above references, it's also obvious why ivermectin is
selected in our top 10 list.
Concerns and Cautions:
- Ivermectin has a number of potentially serious drug-drug interactions. Please check for potential drug interaction at Ivermectin Drug Interactions - Drugs.com. The most important drug interactions occur with cyclosporin, tacrolimus, anti-retroviral drugs, and certain anti-fungal drugs.
- Ivermectin is also lipophilic and therefore, bioavailability is maximised on a full stomach; or best to be taken with meal.
3. Hydroxychloroquine
While this treatment has generated controversy as well, we have
included it in order to acknowledge its popularity and provide a
more balanced perspective.
Hydroxychloroquine, developed in the 1950s from chloroquine, an old anti-malarial drug, is registered in around 60 countries under trade names such as Plaquenil, Quensyl and Plaquinol.
Hydroxychloroquine, a less toxic derivative of Chloroquine is also a widely used medication by people with lupus or
arthritis.
Hydroxychloroquine (HCQ) is not effective when used very late
with high dosages over a long period (RECOVERY/SOLIDARITY),
effectiveness improves with earlier usage and improved dosing.
Early treatment consistently shows positive effects. Negative
evaluations typically ignore treatment time, often focusing on
a subset of late stage studies.
The evidence tracking on Hydroxychloroquine versus COVID-19
is available at c19hcq.com (constantly updated).
4. Dietary Supplements (Vitamin D, C, Zinc, Quercetin and Melatonin)
There are more than 100 types of supplements that are being tested for COVID-19. You can review the details of these trials on clinicaltrials.gov.
Please be aware that for optimal effectiveness, it is important to
consider that each supplement should not be viewed as a standalone
intervention, as many supplements are administered as part of combination
protocols. Additionally, the interaction between nutrients should also be
taken into account. For instance, vitamin C and zinc should be
administered together with copper. Similarly, vitamin D3 should be taken
alongside vitamin K2 and magnesium.
Quercetin, Hydroxychloroquine, EGCG and Zinc are among the handful of COVID-19 treatments that are
being studied as candidates that might influence the outcome in the
prevention and management of COVID-19. Hydroxychloroquine, Quercetin and
EGCG (EpiGalloCatechin Gallate) are all zinc ionophores. Meaning they all
transport zinc into the cells.
The combination of quercetin, zinc, vitamin D, vitamin C and melatonin
offer a high virus inhibiting and anti-inflammatory potential with a
valuable degree of safety at a time of great uncertainty.
That said, based on the evidence on C19Early database, a combination
of vitamin D, quercetin, black seed oil, vitamin A, curcumin and
melatonin might even offer a greater probability of improvement if given as
early treatment.
Quercetin, zinc, vitamin D and C are all part of the FLCCC I-MASK+ protocol.
Nutrients and supplements are safer alternatives especially if your
risk is low e.g. age below 50 and no other chronic illness. Discuss
with your doctor on the benefit vs risk for each treatment. If you
are on multiple medications, be aware of supplement-drug
interactions that might enhance the possibilities of adverse
effects.
However, if your risk is high e.g. age above 60, hypertensive,
diabetic and obese; you might wish to consult a doctor and
discuss more potent alternatives in the FLCCC
I-MASK+ protocol.
Note: The dosages for prevention and treatment protocols are different
as the risks and benefits are different for different situations.
Prevention protocol is for those who are not COVID-19 positive and the
treatment protocol is for those who are COVID-19 positive. Do take note
that 'early' treatment is important for the best possible outcome.
5. Paxlovid and COVID-19
Paxlovid is a combination of two antiviral pills: nirmatrelvir and
ritonavir.
Paxlovid is authorized for adults and children ages 12 and older that weigh at least 88 pounds (40 kg). Paxlovid is currently only recommended for people at high risk of developing severe COVID-19. High-risk people include older adults and those with certain medical conditions.
The latest (last updated: April 20, 2023) NIH guidelines recommended Paxlovid as the no. 1 preferred therapy for non-hospitalized patients.
The drug, Paxlovid (ritonavir-boosted nirmatrelvir), is a faster,
cheaper way to treat early COVID-19 infections, though initial
supplies will be extremely limited. All of the previously authorised
drugs against the disease require an IV (intravenous) or an injection.
The updated provider Fact Sheet, Letter of Authorization, and Dear Healthcare Provider Letter are available for reference.
Precaution: PAXLOVID is not recommended (the appropriate
dose has not been determined) in patients with severe renal impairment
(<30 mL/min). (Source)
6. Povidone Iodine, Mouthwash and Nasal Spray
Due to the presence of angiotensin-converting enzyme 2 (ACE2) in the oral gingival epithelium and salivary glands, the human oral cavity may act as a reservoir for SARS-CoV-2. The ACE2 present on the host cell membrane acts as the primary entry receptor for SARS-CoV-2. Evidence indicates that the saliva of SARS-CoV-2-infected individuals contains high amounts of viral RNA and that aerosols formed from the saliva can act as a potential vector for viral transmission.
Povidone iodine (PVP-I) is an antiseptic that has been used for over 150 years. It's already proven that different concentration of PVP-I can deactivate COVID-19 virus.
The antiseptic povidone-iodine has immediate virucidal effects against
COVID-19 virus. There are 20 published studies on povidone-iodine for
COVID-19 (c19pvpi.com) with one study showing an 88% lower risk of death, if given
early.
7. Azithromycin and Antibiotics
Azithromycin is a widely prescribed generic antibiotic. Yes, we do know that COVID-19 is a viral disease and we need an anti-viral and not an anti-bacterial?
While it's mainly used to fight bacteria, not viruses, there is some
research suggesting the drug has antiviral properties.
As of June 2023, there are more than 140 studies that have been launched to investigate the benefits of Azithromycin against COVID-19. You can review the status of these trials on clinicaltrials.gov.
Several trials are testing azithromycin in combination with hydroxychloroquine.
As of June 2023, there are more than 140 studies that have been launched to investigate the benefits of Azithromycin against COVID-19. You can review the status of these trials on clinicaltrials.gov.
Several trials are testing azithromycin in combination with hydroxychloroquine.
Secondary bacterial infection of the lung (pneumonia) was extremely common
in patients with COVID-19, affecting almost half the patients who required
support from mechanical ventilation. By applying machine learning to
medical record data, scientists at Northwestern University Feinberg School
of Medicine found that secondary bacterial pneumonia that does not resolve
was a key driver of death in patients with COVID-19. It may even exceed
death rates from the viral infection itself.
The scientists also found evidence that COVID-19 does not cause a "cytokine storm," so often believed to cause death.
The study was published in the Journal of Clinical Investigation (2023).
"Our study highlights the importance of preventing, looking for and aggressively treating secondary bacterial pneumonia in critically ill patients with severe pneumonia, including those with COVID-19," said senior author Dr. Benjamin Singer, an associate professor of medicine at Northwestern University Feinberg School of Medicine and a Northwestern Medicine pulmonary and critical care physician.
The scientists also found evidence that COVID-19 does not cause a "cytokine storm," so often believed to cause death.
The study was published in the Journal of Clinical Investigation (2023).
"Our study highlights the importance of preventing, looking for and aggressively treating secondary bacterial pneumonia in critically ill patients with severe pneumonia, including those with COVID-19," said senior author Dr. Benjamin Singer, an associate professor of medicine at Northwestern University Feinberg School of Medicine and a Northwestern Medicine pulmonary and critical care physician.
One potential concern of azithromycin is serious heart side effects. Both drugs can cause abnormal changes in the rhythm of the heart. These can be fatal, particularly for susceptible patients who already have heart problems. Many studies are using EKG tests to closely monitors patients receiving this treatment combination.
While QT-prolonging medication use has been associated with increased risk of death, this risk may be smaller than the potential benefit from treatment of COVID-19 for some patients (American College of Cardiology).
8. Vitamin A
Summary results of 10 vitamin A and COVID-19 studies are available on
this dedicated webpage: c19early.com/va.
Based on this early treatment mortality studies drug league table below, vitamin A might even out-perform vitamin D, ivermectin and hydroxychloroquine:
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That said, most clinicians will use the multi-drug or combination approach to get the best outcome. Further, the sorting of the table above is based on only 1 vitamin A study.
There are more than 20 completed studies of curcumin in COVID-19 that suggest that it improves
clinical outcome of patients.
The improvement rate of 84% has made curcumin ranked No. 6 in the COVID-19 early treatment mortality (death rate) studies league table, better than ivermectin, hydroxychloroquine and quercetin.
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Please check this page regularly for updates – new natural
alternatives may be added and/or dose changes to existing
alternatives may be made as further scientific studies
emerge.
As you can see from the treatment league table above, some of the
'natural alternatives' (including diet (R) and exercise (R)) might even perform better than synthetic drugs.
9. Curcumin (Turmeric) - Anti-inflammatory and anti-viral
Curcumin, a yellow carotenoid from turmeric, is a nutritional
therapeutic recommended as part of the FLCCC I-CARE early
treatment protocol, and has antiviral, anti-inflammatory,
antioxidant and immune modulating properties.
Curcumin also acts as natural zinc ionophores and can promote
the cellular uptake of zinc and can be used with zinc to
increase the effectiveness of these compounds in the inhibition
of the virus (Ref).
The improvement rate of 84% has made curcumin ranked No. 6 in the COVID-19 early treatment mortality (death rate) studies league table, better than ivermectin, hydroxychloroquine and quercetin.
10. Other Potential Treatments
There are over two dozen compounds that have shown effectiveness
in treating COVID-19. For a list of COVID-19 early treatment
studies, check out c19early.com (constantly updated).
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Summary
The combination of quercetin, zinc, vitamin D, vitamin C and
melatonin offer a high virus inhibiting and anti-inflammatory
potential with a valuable degree of safety at a time of great
uncertainty.
That said, based on the above evidence, a combination of vitamin D,
quercetin, black seed oil, vitamin A and melatonin might even offer
a greater probability of improvement if given as early treatment.
Quercetin, zinc, vitamin D and C are part of the FLCCC's I-CARE protocol.
Nutrients and supplements are safer alternatives especially if
your risk is low e.g. age below 50 and no other chronic illness.
Discuss with your doctor on the benefit vs risk for each
treatment. If you are on multiple medications, be aware of
supplement-drug interactions that might enhance the
possibilities of adverse effects.
However, if your risk is high e.g. age above 60, hypertensive,
diabetic and obese; you might wish to consult a doctor and
discuss more potent alternatives in
the FLCCC's I-CARE protocol.
If you review most of the above studies, you will find a very
common theme among most of the studies. A key highlight is that
'early treatment' results tend to be better than 'late
treatment' results. Therefore, the most important takeaway is to
get 'early treatment'. That said, you should never attempt to
self medicate without the guidance of a licensed medical
provider. If you are not a medical doctor, you are likely to
find the information above overwhelming.
Please also follow other precautions and measures (as advised by
your local health authorities and doctors) in order to minimize your
risk.
Treatments do not replace vaccines and other measures. All
practical, effective, and safe means should be used. Elimination is
a race against viral evolution. No treatment, vaccine, or
intervention is 100% available and effective for all variants.
The combination of quercetin, zinc, vitamin D, vitamin C and
melatonin offer a high virus inhibiting and anti-inflammatory
potential with a valuable degree of safety at a time of great
uncertainty.
That said, based on the above evidence, a combination of vitamin D,
quercetin, black seed oil, vitamin A and melatonin might even offer
a greater probability of improvement if given as early treatment.
Quercetin, zinc, vitamin D and C are part of the FLCCC's I-CARE protocol.
Nutrients and supplements are safer alternatives especially if
your risk is low e.g. age below 50 and no other chronic illness.
Discuss with your doctor on the benefit vs risk for each
treatment. If you are on multiple medications, be aware of
supplement-drug interactions that might enhance the
possibilities of adverse effects.
However, if your risk is high e.g. age above 60, hypertensive,
diabetic and obese; you might wish to consult a doctor and
discuss more potent alternatives in
the FLCCC's I-CARE protocol.
If you review most of the above studies, you will find a very
common theme among most of the studies. A key highlight is that
'early treatment' results tend to be better than 'late
treatment' results. Therefore, the most important takeaway is to
get 'early treatment'. That said, you should never attempt to
self medicate without the guidance of a licensed medical
provider. If you are not a medical doctor, you are likely to
find the information above overwhelming.
Please also follow other precautions and measures (as advised by
your local health authorities and doctors) in order to minimize your
risk.
Z-Stack Supplement
In an effort to make it easier for patients, Dr Zelenko has
developed an oral supplement that contains all four key
ingredients: vitamin C, quercetin, vitamin D3 and zinc. It’s
referred to as 'Z-Stack Supplement'.
Z-Stack Vitamin cocktail provides key ingredients needed in order to help your body fight off this deadly invader. The Z-Stack Vitamins are Kosher certified, GMP certified and made in the USA.
The cost of the Z-STACK vitamin cocktail is $55 per bottle for a one
month supply.
Where to buy Z-Stack: Z-stack is available on Dr
Zelenko's website. Here is the link: Z Stack Supplement
Note: To get 5% OFF, please use this coupon code: drfrancis
Disclaimer: All information presented is not intended to replace the
guidance from your medical doctor. Please discuss with your doctor
before you take any supplement or medication related to COVID-19.
Read more: Explore COVID-19 Articles
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