The Aesthetics Advisor

I recently posted   an article detailing the importance of niacinamide   (aka, nicotinamide, a form of vitamin B3 or niacin) for healthy mitochondrial function and cellular energy production, and how it can help reverse obesity and leaky gut, and prevent neurodegeneration, kidney disease and heart failure. Here, I’ll review several additional conditions that can be prevented and/or treated with this inexpensive and readily available supplement. More Niacinamide Is NOT Better, There’s a Goldilocks’ Dose Keep in mind that the dosages used in the research studies discussed below do vary widely, but as a rule, I only recommend taking small doses of 50 milligrams of niacinamide three times a day. This dosage has been shown to optimize energy metabolism and boost NAD+ levels, which are foundational for everything else to work. It can be taken four times a day if you space them out. Take a dose as soon as you get up, before going to bed, and twice evenly spaced between those times. T...

High levels of niacin, also known as vitamin B3, have been shown to contribute to cardiovascular disease in a recent study. The 2024 study out of the Cleveland Clinic, published in Nature Medicine , determined there is a delicate balance between too much niacin and just enough—a sort of Goldilocks effect. Niacin used to be a first choice for lowering LDL, or “bad,” cholesterol. However, as observed by the Cleveland Clinic team, too much niacin creates a byproduct known as 4PY. This product circulates within the bloodstream and is associated with a higher risk of heart attack, stroke, and other cardiac events. Additionally, 4PY was shown in preclinical studies to trigger vascular inflammation, damaging blood vessels and eventually leading to atherosclerosis. The researchers discovered this by examining data from 1,162 patients who had experienced major cardiovascular events. Just under half of the patients (442) were female. Initially, the team sought common markers that could lead to c...

Introduction Niacin, niacinamide, and nicotinamide are different forms of vitamin B3, also known as niacin or nicotinic acid. These forms of vitamin B3 are often used interchangeably, but they have unique properties and benefits that make them distinct from one another. In this article, we will discuss the differences between niacin, niacinamide, and nicotinamide, and the benefits and drawbacks of each. Niacin: Niacin, also known as vitamin B3, is an essential nutrient that plays a vital role in energy production, DNA repair, and cell signaling. It is water-soluble and is not stored in the body, which means that it must be obtained through the diet or supplementation. Niacin is used to treat a variety of conditions, including high cholesterol, cardiovascular disease, and diabetes. It has been shown to lower LDL (bad) cholesterol and triglycerides while increasing HDL (good) cholesterol. Niacin is also effective in reducing the risk of heart attack and stroke. However, niacin is also kn...

David Sinclair, a tenured professor of genetics at Harvard University, established a series of anti-aging regimens that have made him appear and feel about 20 years younger. In addition to exercise and diet, the nutrient nicotinamide mononucleotide (NMN), which he takes orally every day has become the focus of attention. Aging is an inevitable destiny of mankind, yet we have long and relentlessly searched for ways to delay its arrival. Mr. Sinclair has conducted a series of laboratory studies over the past 20 years and succeeded in discovering certain vital factors related to aging and has applied those findings to himself and his family. They include special exercise routines, dietary modifications, nutrient supplements, and the use of certain medications. Mr. Sinclair himself and those who interview him say he looks younger and is more energetic than he was 20 years ago. How does this top anti-aging expert do it? Is there any scientific basis for his approach? In this article, we...