NMN: David Sinclair Demonstrates Its Anti-Aging Effects
David Sinclair, a tenured professor of genetics at Harvard University, established a series of anti-aging regimens that have made him appear and feel about 20 years younger. In addition to exercise and diet, the nutrient nicotinamide mononucleotide (NMN), which he takes orally every day has become the focus of attention.
Aging is an inevitable destiny of mankind, yet we have long and relentlessly searched for ways to delay its arrival. Mr. Sinclair has conducted a series of laboratory studies over the past 20 years and succeeded in discovering certain vital factors related to aging and has applied those findings to himself and his family. They include special exercise routines, dietary modifications, nutrient supplements, and the use of certain medications.
Mr. Sinclair himself and those who interview him say he looks younger and is more energetic than he was 20 years ago.
How does this top anti-aging expert do it? Is there any scientific basis for his approach? In this article, we'll explore what may be the most important discovery of his research—NMN—the nutrient he takes as a supplement every day. Is this nutrient safe? What effect does it have on animals and human beings? Are there any consequences for our long-term health? Let us address these questions.
Mr. Sinclair himself and those who interview him say he looks younger and is more energetic than he was 20 years ago.
How does this top anti-aging expert do it? Is there any scientific basis for his approach? In this article, we'll explore what may be the most important discovery of his research—NMN—the nutrient he takes as a supplement every day. Is this nutrient safe? What effect does it have on animals and human beings? Are there any consequences for our long-term health? Let us address these questions.
Key Factors in Aging: Mitochondria and NAD+
Mitochondria are organelles (subcellular structures) present in every cell of the body. They are the powerhouses that release energy in cells and are the main sites where cells conduct aerobic respiration. The process that our cells use to produce energy requires the help of a particularly important enzyme, which is referred to as NAD+. It is valuable to our body because of its capability to facilitate the energy production process from the cells becoming more efficient.NAD+ levels are high at birth and reach their prime by adolescence. The decline of NAD+ indicates that the function of mitochondria to produce energy through internal metabolism is waning. This corresponds to the view of traditional Chinese medicine (TCM) in which qi—the human body’s internal energy—is declining, manifesting in aging.
Anti-Aging Nutrient NMN: Precursor of NAD+
NAD+ itself is somewhat unstable and is easily decomposed after passing through the digestive tract. Mr. Sinclair found that NMN, the precursor of NAD+, can be converted into NAD+ after reaching the cells. This is equivalent to increasing the level of NAD+ in the blood, which then achieves the objective of delaying aging.Anti-Aging Effects of NMN Supplementation in Animals
Mr. Sinclair found that after supplementing NMN in mice for a period, they performed better on the treadmill, showing strong functionality, and appearing much younger than mice not treated with NMN. He also found that NMN can improve the memory, attention, and even hearing of mice. Additionally, NMN can improve functions of the heart, liver, and kidneys, activate the anti-aging mechanism in the body, and immensely improve immune function.Anti-Aging Effects of NMN in Human Trials
Mr. Sinclair began taking the same NMN that he used for the experiments on mice. Since then, there have been numerous oral NMN supplements on the market. Some clinics specialize in anti-aging therapy and inject NAD+ intravenously to boost the level of NAD+ in the body.Experiments in various countries, including Japan and the United States, by Mr. Sinclair and other scientists led to the following major findings:
1. NMN is safe as a supplement up to a daily dose of 500 mg per day with some studies suggesting up to 900 mg per day.
2. NMN as a nutrient can improve the physiological functionalities of the human body and improve all aging metrics. Physiological functionalities here include strength, endurance, speed, and muscle strength. It is also evident that NMN can improve the response of muscle cells to insulin, help control blood sugar, and reduce resistance to insulin.
NMN is also found to improve hearing in the ears of some people, which is a good indication of its tonic effect on kidney qi. TCM believes that kidney qi is the innate qi that determines a person’s life span. If kidney qi is insufficient, the body will age, and hearing will also decline.
3. The body has an excellent biomarker to define aging called telomeres, which are consumed during DNA replication. Telomeres ensure that DNA does not go wrong during replication. Immediately at birth, more than half of the body’s telomeres are consumed, and as one grows older, the amount of telomeres continues to decrease. In other words, aging can be judged by detecting the length of the telomeres. NMN as a nutrient can increase the length of the DNA telomeres, which means that NMN has all the anti-aging potential at the molecular level, can activate the human body’s anti-aging mechanism, and can delay the process of cellular aging.
Two Mechanisms Inside the Human Body: Aging and Anti-Aging
Two sets of mechanisms inherent in the body reflect the mystique and delicacy of how God created man. On one hand, there is a mechanism that ensures the body undergoes natural aging from birth through old age, illness, and death. At the same time, to avoid premature death, the human body has another anti-aging mechanism—the balance of these two mechanisms determines the length of individual human life.The body is the vessel of the soul. Without the former, the latter has nowhere to stay. Therefore, we need to treat our bodies well and pay special attention to their care.
However, nowadays, people’s lifestyles and living environments have made the mechanism of aging more active, while the anti-aging mechanism has not been fully stimulated. From a certain perspective, NMN as a nutritional supplement may be an opportunistic approach.
NMN Prospects and Recommendations
Mr. Sinclair discovered in animal experiments that the anti-aging effects of NAD+ and its precursor NMN have been confirmed to be safe and effective in human studies too. It is found to improve certain physiological functionalities and aging indicators related to the aging process in the middle-aged and elderly, and more effects are yet to be studied.At the moment, NMN has been removed from the category of nutrients by the U.S. Food and Drug Administration and is being studied as a drug. Mr. Sinclair is now collaborating with pharmaceutical companies to turn NMN into an approved drug. To ensure the quality of NMN ordered online, it is recommended to check the legitimacy of the websites.
Reposted from: https://www.theepochtimes.com/health/nmn-harvard-professor-demonstrates-its-anti-aging-effects-5587599
This article is part of the Anti Aging series.
.png)
Comments
Post a Comment