12 Best Quercetin and Zinc Supplements of 2022

Zinc is a powerful immune nutrient known for its benefits for providing immune health support and inflammation reduction as well as for improving cold and respiratory symptoms, wound healing, acne reduction, and lowering the risk of age-related diseases. 

Quercetin has anti-inflammatory and antioxidant properties that can help combat various chronic diseases. In addition, quercetin is also a zinc ionophore that helps to transport zinc molecules into the cells.

Therefore, quercetin and zinc in combination exerts a synergistic antiviral, anti-inflammatory and antioxidant properties. Zinc and quercetin are also part of the FLCCC I-MASK+ protocol for the prevention and early treatment of COVID-19.

What Is Quercetin?

Quercetin is an antioxidant that belongs to a class of water-soluble plant substances called flavonoids, which are present in certain fruits and vegetables. According to an article in Current Research in Nutrition and Food Science, the bioavailability of quercetin absorbed by your body varies, depending on the source where you get it, as well as your individual body’s metabolism of it. Sugar and dietary fat and fiber also affect it.

While the best way to get quercetin is through your diet, it also is available in supplement form, as pills or capsules. Sometimes, quercetin in supplement form is packaged with bromelain, an enzyme found in pineapples, because both have anti-inflammatory properties (Quercetin & Bromelain for inflammation). Most dietary supplements contain a chemical compound, aglycone, which is the free form of quercetin.

When looking for and using quercetin supplements, it’s important to maintain a nutritious, balanced diet with fiber and healthy fats in it, as research shows that accumulation of quercetin in the body is dependent on “factors such as glucose moieties, solubility, human factor, vitamin C status and food matrix.”

Specifically, research also says that quercetin supplementation is best achieved when consumed with a fat-enriched diet.

best quercetin and zinc supplement


There are foods high in quercetin that you can add to your diet. Arguably, red onions are some of the most potent sources of quercetin; one study found that absorption of onion-derived quercetin was 52% compared to only 24% in supplement form. In fact, onions can give you three times the amount of quercetin than you’d get from apples. Other food sources that are high in quercetin include:
  • Organically grown apples, grapes and tomatoes
  • Dark cherries and dark berries like blueberries, blackberries and bilberries (eaten in moderation)
  • Cocoa, unsweetened
  • Hot green chili peppers
  • Lingonberries

Benefits of Quercetin

Quercetin has been linked to the following health benefits:
  • Possessing anti-inflammatory, antioxidant properties that can help combat certain diseases. One study found that 500 mg of quercetin a day could improve symptoms of rheumatoid arthritis.
  • Helping prevent cancer cell growth from breast, colon, prostate, endometrial and lung.
  • Counteracting allergic reactions and helping with immune responses.
  • Helping to prevent osteoporosis
  • Addressing cognitive decline, including Alzheimer’s and dementia.
  • Assisting in control of blood pressure. A study in 2002 found that quercetin can have vasodilator effects.
  • Potentially helping to lower blood sugar levels. One study found that dosages of 500 mg per day “significantly reduced” fasting glucose levels.

Quercetin, Zinc, Vitamin C and Vitamin D (FLCCC I-MASK+ Protocol)

Incidentally, ascorbic acid (vitamin C) and the bioflavonoid quercetin (originally labeled vitamin P) were both discovered by the same scientist — Nobel prize winner Albert Szent-Györgyi. Quercetin and vitamin C also act as an antiviral drug, effectively inactivating viruses. 

There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy.

For updated prevention and early outpatient protocol  for COVID-19 positive, please check out FLCCC I-MASK+ protocol.

Quercetin, Zinc, Vitamin D and Vitamin C - Dr Zelenko Protocol for COVID-19

According to Dr. Zelenko, the best over the counter substitute or natural alternative to hydroxychloroquine is quercetin. 

When hydroxychloroquine is not available, Dr. Zelenko recommends the following OTC (over-the-counter) treatment in the early stages of COVID-19 and quercetin as a natural alternative to hydroxychloroquine. He recommends this treatment immediately after you have symptoms.
  • Zinc 50mg 1 time a day for 7 days (PubMed)
  • Quercetin 500mg 2 times a day for 7 days (PubMed)
  • Vitamin C 1000mg 1 time a day for 7 days 
  • Vitamin D3 5000 IU 1 time a day for 7 days 
As a prevention treatment, Dr. Zelenko recommends the OTC (over-the-counter) alternatives to hydroxychloroquine. His prophylaxis protocol for COVID-19 is the following:

What is Zinc?

Zinc is a powerful immune nutrient known for its benefits for providing immune health support and inflammation reduction as well as for improving cold and respiratory symptoms, wound healing, acne reduction, and lowering the risk of age-related diseases. Research on atherosclerosis and diabetes mellitus suggests that zinc deficiency may contribute to low-grade systemic inflammation.

Even more popular at the moment is the role of zinc and the potential benefits against COVID-19. This is probably one of the reasons that's driving the demand on zinc related products. In a ConsumerLab survey of 9,647 people who use dietary supplements shows that the supplements which experienced the greatest growth in popularity in 2020 were those being promoted to prevent or treat infection with SARS-CoV-2, the coronavirus that causes COVID-19. Zinc supplements achieved the highest growth with 13.5% points.

Does zinc help treat COVID 19? Check out the evidence tracker on zinc and COVID-19 from c19zinc.com (constantly updated).

Are all zinc supplements the same? The zinc supplements in this review are all manufactured by reputable companies that follow Good Manufacturing Processes (GMP), use high quality ingredients, and test for purity and quality.

Best Zinc and Quercetin Supplements of 2022

Here are the best zinc and quercetin supplements to help you meet your nutritional needs. There is no one size fits all supplement. As everyone has their own set of criteria, the best option for you might not be suitable for another person.

1. Sandhu's Zinc Quercetin 120 Vegetarian Capsules


SHOP NOW ON AMAZON

Price: $11.39

Amazon Best Sellers: #3 Best Seller in zinc mineral supplements. 4.8 out of 5 overall rating with more than 8,000 customer reviews.
  • Supports immune system health
  • 60 servings per bottle
  • Supports cardiovascular health

2. Z-Stack Quercetin 500 mg with Zinc, Vitamin C and Vitamin D3 - Best Immune Support Supplement 

Z STACK Zelenko

Where to buy Z-StackZ Stack Supplement 
Note: To get 5% OFF, please use this coupon code: DRFRANCIS

In an effort to make it easier for his patients, Dr Zelenko has developed an oral supplement that contains four key ingredients including quercetin (a zinc ionophore) in combination with zinc, vitamin C and vitamin D3. It’s referred to as 'Z-Stack Supplement'. 

Each capsule contains 250 mg of quercetin, 15 mg of zinc, 2,500 IU of vitamin D3 and 400 mg of vitamin C. Cost per capsule: $0.83.

Z-Stack Vitamin cocktail provides key ingredients needed in order to help your body fight off this deadly invader. The Z-Stack Vitamins are Kosher certified, GMP certified and made in the USA.

Quercetin is a zinc ionophore. Meaning it transports zinc into the cells. 

It is known that zinc will slow down the replication of coronavirus through inhibition of enzyme RNA dependent RNA polymerase (PubMed 2010). The COVID-19 virus is a single stranded RNA (RiboNucleicAcid) virus and requires the RNA polymerase to replicate. 

Vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy.

Vitamin D is essential to a healthy immune system as it initiates the adaptive immune response. Clinical trial data shows that Vitamin D supplementation is safe and protects against acute respiratory tract infection mortality whereas low levels of vitamin D are associated with higher risk for infection and mortality (bmj.com). 

Customer Review on ZStackLife:
My father and I have been taking Z Stack for 4 months. My wife has not. She came down with C-19. I still slept in the same bed with her and neither my father nor I got sick. She started the protocol and was fine in a few days. I'm sold on this product. - Feb 4, 2022

Related Evidence:
  • What is the Zelenko protocol? The Zelenko COVID-19 Protocol was developed by Dr Vladimir Zelenko. A retrospective study analyzing Dr Zelenko's patient data was accepted for publication in the International Journal of Antimicrobial Agents after a rigorous peer review process. The study finds that early intervention and treatment of high-risk patients with COVID-19 resulted in significantly fewer hospitalizations and deaths. The treatment consisting of zinc, low-dose hydroxychloroquine (HCQ), and azithromycin, is also referred to as "The Zelenko Protocol." Dr Zelenko has since updated his protocols to incorporate new evidence.

3. Mt Angel Vitamins Quercetin Zinc 


FORTIFIED FUNCTION – Sick of stuffy, sneezy, seasonal illnesses? Fight flare-ups with Mt. Angel Vitamins’ quercetin supplement! This nutrient blend helps boost better health so you can feel your best!

OVERALL AID – Bolster your body AND mind! Quercetin with vitamin C and zinc are proven not only to provide immune support but also to improve metabolism, circulatory supporty, and cognitive clarity!

BREATHE & BOUND – Revive your vitality! By fostering cellular functioning, your zinc quercetin capsules’ antioxidants enhance respiratory health and energy levels so you can enjoy activities!

TAKE IT EASY – Support, meet simplicity. To enjoy extra defense, take 1 of your quercetin with bromelain and zinc capsules twice daily. Bursting with 300 capsules, your bottle lasts longer than most brands’.

Our Take: Quercetin works best when taken with vitamin C and Bromelain, as vitamin C helps activate it and bromelain helps with the absorption. That’s why many quercetin supplements contain vitamin C or bromelain, as some evidence suggests they boost absorption.

Ratings4.7 out of 5 - more than 1000 global ratings

ReviewsMy husband read the Swiss protocal for Covid 19 preventative and this has it all. So far so good no problems. No bad taste easy to swallow, our 12yr old son even has no problem.

4. Supplements Studio Quercetin with Bromelain-Zinc-Vitamin C-Ginger



Reviews: 4.8 out of 5 - more than 200 global ratings (Amazon)
  • 3 MONTH SUPPLY OF HIGHEST QUALITY IMMUNE SYSTEM SUPPORT COMPLEX - Quercetin 500 mg + 175 mg of Organic Whole Food Quercetin Blend(4 Organic Whole Food Quercetin source ingredients) + 15 mg of Zinc Picolinate + 200 mg of Bromelain from Pineapple + 100 mg of Organic Ginger Root + 125 mg of Vitamin C from Organic Acerola Cherries + 100 mg of Citrus Bioflavonoids from Organic Orange & Organic Lemon
Dosage - 250mg Quercetin Dihydrate, 7.5mg Zinc, 100mg Bromelain

5. Vitaraw Quercetin, Zinc, Bromelain, Vitamin C, Vitamin D3



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- Immunity Booster, Antioxidant & Anti Inflammatory 

The Ultimate Immune Defense by Vita Raw
Quercetin carries anti-aging elements that promote blood sugar levels and stronger endurance while acting as an anti-inflammatory supplement. Bromelain is the principal ingredient that enhances the potency and absorption of Quercetin.

An all-in-one premium daily immune vitamin made with top quality nutrients at optimal doses. Stay healthy, happy, and energized with a powerhouse multi-vitamin that naturally strengthen your body's defense system.*

An Advanced Formulation Immune Booster For Adults*
Experience a robust antioxidant for cardiovascular and digestive health with VitaRaw's Quercetin + Bromelain + Stinging Nettle Root + Vitamin C with Zinc for adults. Fused with 50 mg of Zinc and 500mg of Vitamin C & Quercetin that reinforces immunity, strong bones, balanced energy levels, and proper growth of the body.*

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

- Gluten-Free & Gelatin-Free
- Vegan & Vegetarian Friendly
- Made With Non-GMO Ingredients
- Safe, Pure, High-Quality Supplements

Quercetin Bromelain with Stinging Nettle Root
- Healthy Digestion & Immune Function Support*
- Strong Antioxidant Properties To Protect The Body From Free Radicals**
- Added Bromelain for Maximum Absorption*
- Maintains General Health*

Dosage (per capsule) : Quercetin 250mg Supplement, Zinc 25mg, Vitamin C 250mg, Vitamin D3 63mg, Bromelain 75mg

Ratings : 4.6 out of 5 - 1,122 global ratings

I started taking this when I began feeling like a cold was coming on. My throat was really bothering me, I had a bad headache, and I was sneezing. Quite honestly, I thought it was something worse than I cold but I remained optimistic. I took the Quercetin immediately and I felt better in a couple days. From my experience, it seemed to prevent my symptoms from worsening. My back also feels a little better. I sit a lot so this supplement might be helping with the discomfort I normally have.

Best Zinc Supplements of 2022

Are all zinc supplements the same? The zinc supplements in this review are all manufactured by reputable companies that follow Good Manufacturing Processes (GMP), use high quality ingredients, and test for purity and quality.

Here are the best zinc supplements to help you meet your nutritional needs. As everyone has their own set of criteria, the best option for you might be different from another person.

6. Zinc Lozenges with Vitamin C - Healthy Immune Support Lozenges with 25mg of Zinc Supplement Per Lozenge + 30mg of Vitamin C 

 
Check Price on Amazon
  • Amazon's Choice for Zinc Lozenges.
  • Nutritionally Supports a Healthy Immune System*
  • Formulated with a perfect balance of 25 mg of Zinc, 30 mg of Vitamin C, 2mg of Vitamin B6, and a Proprietary Blend of Royal Jelly, White Willow Bark Ext., and Slippery Elm Bark Powder
  • Almost TWICE the amount of zinc per lozenge of cold-EEZE zinc lozenges*
  • Fruit Flavored to provide children zinc lozenges without a large amount of added sugars
  • Internally tested and third party tested to ensure purity and potency so you get the highest quality vitamin
  • Made in the USA in a FDA Registered & Inspected Facility, under Good Manufacturing Practices (GMP's)
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

7. NOW Foods Zinc Glycinate Softgels - Best Chelated


Price: From $11.49

Amazon Reviews: 4.7 out of 5. More than 500 customer reviews.

Chelated zinc is a type of zinc supplement that uses a chelating agent to help your body absorb zinc more easily.

While there are several chelated zinc supplements on the market, one of the best options is NOW Foods’ Zinc Glycinate softgels.

Each softgel contains 30 mg of zinc glycinate — a form of zinc that human and animal studies suggest may be better absorbed than other types of zinc. (Trusted SourceTrusted Source).

All NOW Foods supplements are certified by Underwriters Laboratories and follow GMP to ensure the quality and accuracy of their products. Additionally, these supplements tend to be more affordable than many other high quality brands.

8. Garden of Life Vitamin Code Raw Zinc - Best Vegan Option


Price: $10.49

Amazon Best Sellers: #2 in zinc mineral supplements

Amazon Reviews: 4.8 out of 5. More than 14,500 customer reviews.

While it’s not always obvious, some supplements can contain animal-derived ingredients, making the product unsuitable for vegans.

Some commonly used ingredients that aren’t vegan-friendly include digestive enzymes like lipase, caprylic acid from milk, gelatin, and magnesium stearate, which is often pork-derived.

Garden of Life is a whole-foods-based supplement brand with products that are certified organic and non-GMO verified.

Their Vitamin Code Raw Zinc is a good option for vegans, as it’s third-party tested to ensure the product is vegan, as well as gluten-free.

In addition to providing 30 mg of plant-based zinc, each serving also contains vitamin C, a raw organic fruit and vegetable blend, and live probiotics and enzymes to support healthy digestion.

It’s recommended that adults take one serving of 2 capsules per day with or without meals. For those who have difficulty swallowing pills, the capsules can also be opened to pour the contents into a glass of water or other beverage.

9. Nature's Bounty Zinc 50 mg Caplets


Price: From $5.21

Amazon Reviews: 4.8 out of 5. More than 50,000 customer reviews on Amazon.com.

About this item:
  • This product is the #1 best seller under the zinc mineral supplements on Amazon Best Sellers and has more than 50,000 customer reviews on Amazon.
  • One vegetarian-friendly caplet a day contributes to carbohydrate, protein, fat and energy metabolism, and helps promote wellness in key areas of reproductive health for men.*
  • Plays a key role in the synthesis of testosterone.*
  • *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.

10. Nature's Bounty Immune 24 Hour + - Best Zinc Supplement for Seniors


Price: From $29.49

Amazon Reviews: 4.8 out of 5. More than 19,000 customer reviews on Amazon.com.

Zinc dosage for senior: Men over age 60 do not usually meet their recommended daily zinc needs. On average, males in this demographic get 9.4 milligrams per day, slightly less than the recommendation, according to the Office of Dietary Supplements. In some cases, your doctor may suggest taking a daily multivitamin or zinc supplement to further boost your zinc intake. Zinc can be toxic at high doses, causing severe gastrointestinal problems. It is unlikely to get excessive amounts of zinc from your diet, but you can overdose on supplements. 

About this item:
  • Softgels contain Zinc (15 mg per serving daily; 136% of daily value), Vitamin A, C, D3, B6, B12, Biotin, Folate, Panthotenic Acid, Magnesium, Echinacea, Elderberry, Astralagus.
  • THE ONLY VITAMIN C WITH 24-HOUR IMMUNE SUPPORT: Nature's Bounty Immune 24 Hour + contains 1000mg of Ester-C, the only clinically studied Vitamin C with 24-hour immune support. Ester-C lasts up to 2x longer than regular Vitamin C
  • PLUS VITAMIN D & ZINC, WITH ELDERBERRY AND ECHINACEA: Immune 24 Hour + provides Vitamin D, Vitamin A and Zinc for extra immune plus antioxidant support. Also contains Elderberry and Echinacea, plus 9 essential nutrients to help keep you healthy
  • SUPPORTS UPPER RESPIRATORY HEALTH: Highly bioavailable Ester-C can increase Vitamin C levels in the body, which is important for white blood cell function, contributing to the health of the upper respiratory tract
  • NON-GMO FORMULA: Nature's Bounty Immune 24 Hour + is Non-GMO and contains No artificial flavor or artificial sweeteners, no sugar, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish, sodium free
  • RAPID RELEASE SOFTGELS: For adults, Take 2 softgels daily, preferably with a meal.

Best Quercetin Supplements of 2022

11. Thorne Research Quercenase  


Quercenase is a combination of quercetin phytosome and bromelain. Quercetin phytosome is a new food-grade lecithin-based formulation of quercetin, was developed to overcome the low bioavailability hurdle of quercetin. Phytosome complexes are created by a patented process that binds a botanical extract to a phospholipid (phosphatidylcholine), which are key components of every cell membrane.

Dosage : 250 mg of quercetin phytosome + 100 mg of bromelain.

BestReviews.com: Pricier than many similar products on the market

Ratings : 4.7 out of 5 - More than 1000 ratings

Our Take: If you are looking to buy from a reputable brand, this would be your choice.

Related Evidence: A Randomised Controlled Trial of 152 outpatients with COVID-19 in Pakistan, 76 treated with quercetin phytosome, showed lower mortality, ICU admission, and hospitalization with treatment (International Journal of General Medicine, May 2021)

12. Amazing Formulas - Quercetin 500 Mg


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Amazon Best Sellers: #1 Best Seller in Flavonoid Vitamin Supplements
4.7 out of 5 overall rating with more than 28,000 customer reviews.

- Quercetin is a flavonoid (plant pigment) naturally found in fruits and vegetables. It is found in many foods, such as red wine, onions, green tea, apples, berries etc. It known for its Anti-oxidant and Anti-Inflammatory Properties. Amazing Nutrition Quercetin 500 Mg is offered in Veggie Capsule to suit most diet preferences
- Anti-oxidant properties of Qurecetine Supports Healthy Ageing, Cardiovascular Health, and Immune Health. It helps to reduce the damage and irritation caused by free radicals
- Anti-Inflammatory properties of Quercetin helps to lower the release of histamines, a compound that is released by cells in response to allergic and inflammatory reactions. Subsequently helping to lower pains and discomfort related to Inflammation.
- All Amazing Nutrition products are manufactured in accordance with Good Manufacturing Practices (GMP), among the highest standards in the world.

Dose - 500mg per capsule

I've been sick twice in the past two months, one a mild cold, the other quite severe, DID NOT GET TESTED so can not attest to Covid 19. Anyway, once I got sick, I took 1000mg of Quercetin, combined with 200mg of Zinc Picolinate - ANECDOTAL EVIDENCE: I was free and clear of symptoms in the range of 6 to 10 hours, save for a lingering itch in my sinuses, which was gone after a good nights sleep. Symptoms did not return in either case. This was ONE DOSE.


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