12 Best Quercetin and Zinc Supplements of 2025
Zinc is a powerful immune nutrient known for its benefits for providing
immune health support and inflammation reduction as well as for improving cold
and respiratory symptoms, wound healing, acne reduction, and lowering the risk
of age-related diseases.
Quercetin has anti-inflammatory and antioxidant properties that can
help combat various chronic diseases. In addition, quercetin is also a zinc
ionophore that helps to transport zinc molecules into the cells.
Therefore, quercetin and zinc in combination exerts a synergistic antiviral, anti-inflammatory and antioxidant properties.
What Is Quercetin?
Quercetin is an antioxidant that belongs to a class of water-soluble plant
substances called flavonoids, which are present in certain fruits and
vegetables. According to an article in Current Research in Nutrition and Food Science, the bioavailability
of quercetin absorbed by your body varies, depending on the source where you
get it, as well as your individual body’s metabolism of it. Sugar and dietary
fat and fiber also affect it.
While the best way to get quercetin is through your diet, it also is available in supplement form, as pills or capsules. Sometimes, quercetin in supplement form is packaged with bromelain, an enzyme found in pineapples, because both have anti-inflammatory properties (Quercetin & Bromelain for inflammation). Most dietary supplements contain a chemical compound, aglycone, which is the free form of quercetin.
When looking for and using quercetin supplements, it’s important to maintain a nutritious, balanced diet with fiber and healthy fats in it, as research shows that accumulation of quercetin in the body is dependent on “factors such as glucose moieties, solubility, human factor, vitamin C status and food matrix.”
Specifically, research also says that quercetin supplementation is best achieved when consumed with a fat-enriched diet.
There are foods high in quercetin that you can add to your diet. Arguably, red onions are some of the most potent sources of quercetin; one study found that absorption of onion-derived quercetin was 52% compared to only 24% in supplement form. In fact, onions can give you three times the amount of quercetin than you’d get from apples. Other food sources that are high in quercetin include:
- Organically grown apples, grapes and tomatoes
- Dark cherries and dark berries like blueberries, blackberries and bilberries (eaten in moderation)
- Cocoa, unsweetened
- Hot green chili peppers
- Lingonberries
Benefits of Quercetin
Quercetin has been linked to the following health benefits:- Possessing anti-inflammatory, antioxidant properties that can help combat certain diseases. One study found that 500 mg of quercetin a day could improve symptoms of rheumatoid arthritis.
- Helping prevent cancer cell growth from breast, colon, prostate, endometrial and lung.
- Counteracting allergic reactions and helping with immune responses.
- Helping to prevent osteoporosis
- Addressing cognitive decline, including Alzheimer’s and dementia.
- Assisting in control of blood pressure. A study in 2002 found that quercetin can have vasodilator effects.
- Potentially helping to lower blood sugar levels. One study found that dosages of 500 mg per day “significantly reduced” fasting glucose levels.
Related: Best Quercetin Supplement
What is Zinc?
Zinc is a powerful immune nutrient known for its benefits for providing immune health support and inflammation reduction as well as for improving cold and respiratory symptoms, wound healing, acne reduction, and lowering the risk of age-related diseases. Research on atherosclerosis and diabetes mellitus suggests that zinc deficiency may contribute to low-grade systemic inflammation.
In a ConsumerLab survey of 9,647 people who use dietary supplements shows that the
supplements which experienced the greatest growth in popularity in 2020
were those being promoted to prevent or treat infection with SARS-CoV-2,
the coronavirus that causes COVID-19. Zinc supplements achieved the
highest growth with 13.5% points.
Are all zinc supplements the same? The zinc supplements in this review
are all manufactured by reputable companies that follow Good
Manufacturing Processes (GMP), use high quality ingredients, and test
for purity and quality.
Best Zinc and Quercetin Supplements
1. Sandhu's Zinc, Quercetin, Elderberry, Ginger, Vitamin C and D (Best Zinc with Quercetin)
Buy on Amazon
Trusted by American families for more than 20 years. Sandhu's products have a good number of customer reviews, the highest one being ~18,000 and most of their products have a rating of more than 4.4 stars on Amazon.
Amazon Best Seller: Ranked #1 in Quercetin Supplements with an overall rating of 4.7 out of 5 from over 17,000 customer reviews.
A combination of zinc, quercetin, elderberry, ginger, vitamin C and D to support immune health.
Buy on Amazon
Trusted by American families for more than 20 years. Sandhu's products have a good number of customer reviews, the highest one being ~18,000 and most of their products have a rating of more than 4.4 stars on Amazon.
Amazon Best Seller: Ranked #1 in Quercetin Supplements with an overall rating of 4.7 out of 5 from over 17,000 customer reviews.
A combination of zinc, quercetin, elderberry, ginger, vitamin C and D to support immune health.
2. Z-Stack Quercetin 500 mg with Zinc, Vitamin C and Vitamin D3 - Best Immune Support Supplement
Where to buy Z-Stack: Z Stack Supplement
In an effort to make it easier for his patients, Dr Zelenko has developed an oral supplement that contains four key
ingredients including quercetin (a zinc ionophore) in
combination with zinc, vitamin C and vitamin D3. It’s referred
to as 'Z-Stack Supplement'.
Each capsule contains 250 mg of quercetin, 15 mg of zinc,
2,500 IU of vitamin D3 and 400 mg of vitamin C. Cost per
capsule: $0.83.
Z-Stack Vitamin cocktail provides key ingredients needed in
order to help your body fight off this deadly invader. The
Z-Stack Vitamins are Kosher certified, GMP certified and made
in the USA.
Quercetin is a zinc ionophore. Meaning it transports zinc into the cells.
It is known that zinc will slow down the replication of coronavirus through inhibition of enzyme RNA dependent RNA polymerase (PubMed 2010). The COVID-19 virus is a single stranded RNA (RiboNucleicAcid) virus and requires the RNA polymerase to replicate.
Vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy.
Customer Review on ZStackLife:
My father and I have been taking Z Stack for 4 months. My
wife has not. She came down with C-19. I still slept in the
same bed with her and neither my father nor I got sick. She
started the protocol and was fine in a few days. I'm sold on
this product. - Feb 4, 2022
Related Evidence:
- What is the Zelenko protocol? The Zelenko COVID-19 Protocol was developed by Dr Vladimir Zelenko. A retrospective study analyzing Dr Zelenko's patient data was accepted for publication in the International Journal of Antimicrobial Agents after a rigorous peer review process. The study finds that early intervention and treatment of high-risk patients with COVID-19 resulted in significantly fewer hospitalizations and deaths. The treatment consisting of zinc, low-dose hydroxychloroquine (HCQ), and azithromycin, is also referred to as "The Zelenko Protocol." Dr Zelenko has since updated his protocols to incorporate new evidence.
3. Mt Angel Vitamins Quercetin Zinc
OVERALL AID – Bolster your body AND mind! Quercetin with vitamin C and zinc are proven not only to provide immune support but also to improve metabolism, circulatory supporty, and cognitive clarity!
BREATHE & BOUND – Revive your vitality! By fostering cellular functioning, your zinc quercetin capsules’ antioxidants enhance respiratory health and energy levels so you can enjoy activities!
TAKE IT EASY – Support, meet simplicity. To enjoy extra defense, take 1 of your quercetin with bromelain and zinc capsules twice daily. Bursting with 300 capsules, your bottle lasts longer than most brands’.
Our Take: Quercetin works best when taken with vitamin C and Bromelain, as vitamin C helps activate it and
bromelain helps with the absorption. That’s why many quercetin supplements contain vitamin C or
bromelain, as some evidence suggests they boost absorption.
Ratings: 4.7 out of 5 - more than 1000 global ratings
Reviews: My husband read the Swiss protocal for Covid 19 preventative
and this has it all. So far so good no problems. No bad taste
easy to swallow, our 12yr old son even has no problem.
4. Supplements Studio Quercetin with Bromelain-Zinc-Vitamin C-Ginger
Reviews: 4.8 out of 5 - more than 200 global ratings
(Amazon)
- 3 MONTH SUPPLY OF HIGHEST QUALITY IMMUNE SYSTEM SUPPORT COMPLEX - Quercetin 500 mg + 175 mg of Organic Whole Food Quercetin Blend(4 Organic Whole Food Quercetin source ingredients) + 15 mg of Zinc Picolinate + 200 mg of Bromelain from Pineapple + 100 mg of Organic Ginger Root + 125 mg of Vitamin C from Organic Acerola Cherries + 100 mg of Citrus Bioflavonoids from Organic Orange & Organic Lemon
Dosage - 250mg Quercetin Dihydrate, 7.5mg Zinc, 100mg Bromelain
5. Vitaraw Quercetin, Zinc, Bromelain, Vitamin C, Vitamin D3
Buy on Amazon
- Immunity Booster, Antioxidant & Anti Inflammatory
The Ultimate Immune Defense by Vita Raw
Quercetin carries anti-aging elements that promote blood sugar levels
and stronger endurance while acting as an anti-inflammatory
supplement. Bromelain is the principal ingredient that enhances the
potency and absorption of Quercetin.
An all-in-one premium daily immune vitamin made with top quality
nutrients at optimal doses. Stay healthy, happy, and energized with a
powerhouse multi-vitamin that naturally strengthen your body's defense
system.*
An Advanced Formulation Immune Booster For Adults*
Experience a robust antioxidant for cardiovascular and digestive
health with VitaRaw's Quercetin + Bromelain + Stinging Nettle Root +
Vitamin C with Zinc for adults. Fused with 50 mg of Zinc and 500mg of
Vitamin C & Quercetin that reinforces immunity, strong bones,
balanced energy levels, and proper growth of the body.*
*These statements have not been evaluated by the Food & Drug
Administration. This product is not intended to diagnose, treat, cure
or prevent any disease.
- Gluten-Free & Gelatin-Free
- Vegan & Vegetarian Friendly
- Made With Non-GMO Ingredients
- Safe, Pure, High-Quality Supplements
Quercetin Bromelain with Stinging Nettle Root
- Healthy Digestion & Immune Function Support*
- Strong Antioxidant Properties To Protect The Body From Free
Radicals**
- Added Bromelain for Maximum Absorption*
- Maintains General Health*
Dosage (per capsule) : Quercetin 250mg Supplement, Zinc
25mg, Vitamin C 250mg, Vitamin D3 63mg, Bromelain 75mg
Ratings
: 4.6 out of 5 - 1,122 global ratings
I started taking this when I began feeling like a cold was coming on.
My throat was really bothering me, I had a bad headache, and I was
sneezing. Quite honestly, I thought it was something worse than I cold
but I remained optimistic. I took the Quercetin immediately and I felt
better in a couple days. From my experience, it seemed to prevent my
symptoms from worsening. My back also feels a little better. I sit a
lot so this supplement might be helping with the discomfort I normally
have.
Best Zinc Supplements
Are all zinc supplements the same? The zinc supplements in this
review are all manufactured by reputable companies that follow Good
Manufacturing Processes (GMP), use high quality ingredients, and
test for purity and quality.
Here are the best zinc supplements to help you meet your nutritional needs. As everyone has their own set of criteria, the best option for you might be different from another person.
6. Zinc Lozenges with Vitamin C - Healthy Immune Support Lozenges with 25mg of Zinc Supplement Per Lozenge + 30mg of Vitamin C
Check Price on Amazon
- Amazon's Choice for Zinc Lozenges.
- Nutritionally Supports a Healthy Immune System*
- Formulated with a perfect balance of 25 mg of Zinc, 30 mg of Vitamin C, 2mg of Vitamin B6, and a Proprietary Blend of Royal Jelly, White Willow Bark Ext., and Slippery Elm Bark Powder
- Almost TWICE the amount of zinc per lozenge of cold-EEZE zinc lozenges*
- Fruit Flavored to provide children zinc lozenges without a large amount of added sugars
- Internally tested and third party tested to ensure purity and potency so you get the highest quality vitamin
- Made in the USA in a FDA Registered & Inspected Facility, under Good Manufacturing Practices (GMP's)
7. NOW Foods Zinc Glycinate Softgels - Best Chelated
Price: From $11.49
Amazon Reviews: 4.7 out of 5. More than 500 customer reviews.
Chelated zinc is a type of zinc supplement that uses a chelating
agent to help your body absorb zinc more easily.
While there are several chelated zinc supplements on the market, one of the best options is NOW Foods’ Zinc Glycinate softgels.
Each softgel contains 30 mg of zinc glycinate — a form of zinc that human and animal studies suggest may be better absorbed than other types of zinc. (Trusted Source, Trusted Source).
All NOW Foods supplements are certified by Underwriters Laboratories and follow GMP to ensure the quality and accuracy of their products. Additionally, these supplements tend to be more affordable than many other high quality brands.
While there are several chelated zinc supplements on the market, one of the best options is NOW Foods’ Zinc Glycinate softgels.
Each softgel contains 30 mg of zinc glycinate — a form of zinc that human and animal studies suggest may be better absorbed than other types of zinc. (Trusted Source, Trusted Source).
All NOW Foods supplements are certified by Underwriters Laboratories and follow GMP to ensure the quality and accuracy of their products. Additionally, these supplements tend to be more affordable than many other high quality brands.
Amazon Best Sellers: #2 in zinc mineral supplements
Amazon Reviews: 4.8 out of 5. More than 14,500 customer reviews.
While it’s not always obvious, some supplements can contain animal-derived ingredients, making the product unsuitable for vegans.
Some commonly used ingredients that aren’t vegan-friendly include digestive enzymes like lipase, caprylic acid from milk, gelatin, and magnesium stearate, which is often pork-derived.
Garden of Life is a whole-foods-based supplement brand with products that are certified organic and non-GMO verified.
Their Vitamin Code Raw Zinc is a good option for vegans, as it’s third-party tested to ensure the product is vegan, as well as gluten-free.
In addition to providing 30 mg of plant-based zinc, each serving also contains vitamin C, a raw organic fruit and vegetable blend, and live probiotics and enzymes to support healthy digestion.
It’s recommended that adults take one serving of 2 capsules per day with or without meals. For those who have difficulty swallowing pills, the capsules can also be opened to pour the contents into a glass of water or other beverage.
9. Nature's Bounty Zinc 50 mg Caplets
Amazon Reviews: 4.8 out of 5. More than 50,000 customer reviews on
Amazon.com.
About this item:
- This product is the #1 best seller under the zinc mineral supplements on Amazon Best Sellers and has more than 50,000 customer reviews on Amazon.
- One vegetarian-friendly caplet a day contributes to carbohydrate, protein, fat and energy metabolism, and helps promote wellness in key areas of reproductive health for men.*
- Plays a key role in the synthesis of testosterone.*
- *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
- During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
10. Nature's Bounty Immune 24 Hour + - Best Zinc Supplement for Seniors
Amazon Reviews: 4.8 out of 5. More than 19,000 customer reviews
on Amazon.com.
About this item:
- Softgels contain Zinc (15 mg per serving daily; 136% of daily value), Vitamin A, C, D3, B6, B12, Biotin, Folate, Panthotenic Acid, Magnesium, Echinacea, Elderberry, Astralagus.
- THE ONLY VITAMIN C WITH 24-HOUR IMMUNE SUPPORT: Nature's Bounty Immune 24 Hour + contains 1000mg of Ester-C, the only clinically studied Vitamin C with 24-hour immune support. Ester-C lasts up to 2x longer than regular Vitamin C
- PLUS VITAMIN D & ZINC, WITH ELDERBERRY AND ECHINACEA: Immune 24 Hour + provides Vitamin D, Vitamin A and Zinc for extra immune plus antioxidant support. Also contains Elderberry and Echinacea, plus 9 essential nutrients to help keep you healthy
- SUPPORTS UPPER RESPIRATORY HEALTH: Highly bioavailable Ester-C can increase Vitamin C levels in the body, which is important for white blood cell function, contributing to the health of the upper respiratory tract
- NON-GMO FORMULA: Nature's Bounty Immune 24 Hour + is Non-GMO and contains No artificial flavor or artificial sweeteners, no sugar, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish, sodium free
- RAPID RELEASE SOFTGELS: For adults, Take 2 softgels daily, preferably with a meal.
Best Quercetin Supplements
11. Thorne Research Quercenase
Quercenase is a combination of quercetin phytosome and bromelain.
Quercetin phytosome is a new food-grade lecithin-based formulation
of quercetin, was developed to overcome the low bioavailability
hurdle of quercetin. Phytosome complexes are created by a
patented process that binds a botanical extract to a
phospholipid (phosphatidylcholine), which are key components of
every cell membrane.
Dosage : 250 mg of quercetin phytosome + 100 mg of bromelain.
BestReviews.com: Pricier than many similar products on the market
Ratings : 4.7 out of 5 - More than 1000 ratings
Our Take: If you are looking to buy from a reputable brand, this
would be your choice.
Related Evidence: A Randomised Controlled Trial of 152
outpatients with COVID-19 in Pakistan, 76 treated with quercetin phytosome, showed lower mortality, ICU admission, and hospitalization
with treatment (International Journal of General Medicine, May 2021)
12. Amazing Formulas - Quercetin 500 Mg
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Amazon Best Sellers: #1 Best Seller in
Flavonoid Vitamin Supplements.
4.7 out of 5 overall rating with more than 28,000 customer reviews.
- Quercetin is a flavonoid (plant pigment) naturally found in fruits and
vegetables. It is found in many foods, such as red wine, onions, green
tea, apples, berries etc. It known for its Anti-oxidant and
Anti-Inflammatory Properties. Amazing Nutrition Quercetin 500 Mg is
offered in Veggie Capsule to suit most diet preferences
- Anti-oxidant properties of Qurecetine Supports Healthy Ageing,
Cardiovascular Health, and Immune Health. It helps to reduce the damage
and irritation caused by free radicals
- Anti-Inflammatory properties of Quercetin helps to lower the release
of histamines, a compound that is released by cells in response to
allergic and inflammatory reactions. Subsequently helping to lower pains
and discomfort related to Inflammation.
- All Amazing Nutrition products are manufactured in accordance with
Good Manufacturing Practices (GMP), among the highest standards in the
world.
Dose - 500mg per capsule
I've been sick twice in the past two months, one a mild cold, the
other quite severe, DID NOT GET TESTED so can not attest to Covid 19.
Anyway, once I got sick, I took 1000mg of Quercetin, combined with
200mg of Zinc Picolinate - ANECDOTAL EVIDENCE: I was free and clear of
symptoms in the range of 6 to 10 hours, save for a lingering itch in
my sinuses, which was gone after a good nights sleep. Symptoms did not
return in either case. This was ONE DOSE.
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