12 Best Quercetin and Zinc Supplements 2021

Zinc is a powerful immune nutrient known for its benefits for providing immune health support and inflammation reduction as well as for improving cold and respiratory symptoms, wound healing, acne reduction, and lowering the risk of age-related diseases. Quercetin has anti-inflammatory and antioxidant properties that can help combat various chronic diseases. In addition, quercetin is also a zinc ionophore that helps to transport zinc molecules into the cells.

Therefore, quercetin and zinc in combination exerts a synergistic antiviral, anti-inflammatory and antioxidant properties. Zinc and quercetin are also part of the FLCCC I-MASK+ protocol for the prevention and early treatment of COVID-19.

What Is Quercetin?

Quercetin is an antioxidant that belongs to a class of water-soluble plant substances called flavonoids, which are present in certain fruits and vegetables. According to an article in Current Research in Nutrition and Food Science, the bioavailability of quercetin absorbed by your body varies, depending on the source where you get it, as well as your individual body’s metabolism of it. Sugar and dietary fat and fiber also affect it.

While the best way to get quercetin is through your diet, it also is available in supplement form, as pills or capsules. Sometimes, quercetin in supplement form is packaged with bromelain, an enzyme found in pineapples, because both have anti-inflammatory properties (Quercetin & Bromelain for inflammation). Most dietary supplements contain a chemical compound, aglycone, which is the free form of quercetin.

When looking for and using quercetin supplements, it’s important to maintain a nutritious, balanced diet with fiber and healthy fats in it, as research shows that accumulation of quercetin in the body is dependent on “factors such as glucose moieties, solubility, human factor, vitamin C status and food matrix.”

Specifically, research also says that quercetin supplementation is best achieved when consumed with a fat-enriched diet.




There are foods high in quercetin that you can add to your diet. Arguably, red onions are some of the most potent sources of quercetin; one study found that absorption of onion-derived quercetin was 52% compared to only 24% in supplement form. In fact, onions can give you three times the amount of quercetin than you’d get from apples. Other food sources that are high in quercetin include:
  • Organically grown apples, grapes and tomatoes
  • Dark cherries and dark berries like blueberries, blackberries and bilberries (eaten in moderation)
  • Cocoa, unsweetened
  • Hot green chili peppers
  • Lingonberries

Benefits of Quercetin

Quercetin has been linked to the following health benefits:
  • Possessing anti-inflammatory, antioxidant properties that can help combat certain diseases. One study found that 500 mg of quercetin a day could improve symptoms of rheumatoid arthritis.
  • Helping prevent cancer cell growth from breast, colon, prostate, endometrial and lung.
  • Counteracting allergic reactions and helping with immune responses.
  • Helping to prevent osteoporosis
  • Addressing cognitive decline, including Alzheimer’s and dementia.
  • Assisting in control of blood pressure. A study in 2002 found that quercetin can have vasodilator effects.
  • Potentially helping to lower blood sugar levels. One study found that dosages of 500 mg per day “significantly reduced” fasting glucose levels.

Quercetin and Vitamin C for COVID-19?

There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immuno-modulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy.

For prevention, the Front Line COVID-19 Critical Care Working Group (FLCCC) I-MASK+ protocol recommends (updated April 26, 2021):
  • Vitamin D3: 1000–3000 IU/day. Note RDA (Recommended Daily Allowance) is 800–1000 IU/day. The safe upper-dose daily limit is likely < 4000 IU/day. Vitamin D deficiency has been associated with an increased risk of acquiring COVID-19 and from dying from the disease. Vitamin D supplementation may therefore prove to be an effective and cheap intervention to lessen the impact of this disease, particularly in vulnerable populations, i.e. the elderly and obese. (Amazon)
  • Vitamin C: 500 - 1,000 mg BID (twice daily) 
  • Quercetin: 250 mg daily. It is likely that vitamin C and quercetin have synergistic prophylactic benefit. Quercetin should be used with caution in patients with hypothyroidism and TSH levels should be monitored. (Amazon)
  • Melatonin: 6 mg before bedtime (causes drowsiness). (Amazon)
  • Zinc: 30 - 40 mg/day (elemental zinc). Zinc lozenges are preferred. (Amazon)
  • Ivermectin prophylaxis dosage:
    • prevention for high-risk individuals: 0.2 mg/kg per dose (take with or after meals) — one dose today, repeat after 48 hours, then one dose weekly. 
    • Post COVID-19 exposure prevention: 0.2 mg/kg per dose (take with or after meals)  — one dose today, repeat after 48 hours.
High risk Individuals: > 60 years with co-morbidities (hypertension, diabetes, chronic lung disease, chronic kidney disease), obesity, long term care facilities, etc.

Post COVID-19 exposure: To use if a household member is COVID-19 positive, or you have prolonged exposure to a COVID-19 positive patient without wearing a mask.

Precautionary Note: Ivermectin has a number of potentially serious drug-drug interactions. Please check for potential drug interaction at Ivermectin Drug Interactions - Drugs.com. The most important drug interactions occur with cyclosporin, tacrolimus, anti-retroviral drugs, and certain anti-fungal drugs. 

Due to the possible drug interaction between quercetin and ivermectin (may increase ivermectin levels), these drugs should not be taken simultaneously (i.e. should be staggered morning and night). 

Ivermectin is also lipophilic and therefore, bioavailability is maximised on a full stomach; or best to be taken with meal.

Related: List of Doctors that will prescribe Ivermectin

For early outpatient protocol (COVID-19 positive), the Front Line COVID-19 Critical Care Working Group, FLCCC I-MASK+ protocol recommends (updated Apr 26, 2021):
  • Vitamin D3 — 4000 IU/day. (Amazon)
  • Vitamin C: 500 - 1,000 mg BID (twice daily) (Amazon)
  • Quercetin: 250 mg twice a day. (Amazon)
  • Melatonin: 10 mg before bedtime (causes drowsiness). (Amazon)
  • Zinc: 100 mg/day. Zinc lozenges are preferred. (Amazon)
  • Ivermectin: 0.2–0.4 mg/kg per dose (take with or after meals) — one dose daily, take for 5 days or until recovered. (Find a Doctor). Use upper dose range if:  1) in regions with more aggressive variants; 2) treatment started on or after day 5 of symptoms or in pulmonary phase; or 3) multiple comorbidities/risk factors.
  • Fluvoxamine: 50 mg twice daily for 10–14 days. Add to ivermectin if: 1) minimal response after 2 days of ivermectin; 2) in regions with more aggressive variants; 3) treatment started on or after day 5 of symptoms or in pulmonary phase; or 4) numerous co-morbidities/risk factors. Avoid if patient is already on an SSRI (selective serotonin reuptake inhibitor).
  • Nasopharyngeal Sanitation: Steamed essential oil inhalation 3 times a day (i.e. vapo-rub) and/or chlorhexidine/benzydamine mouthwash gargles and Betadine nasal spray 2–3 times a day.
  • Aspirin: 325 mg/day unless contraindicated.
  • Pulse Oximeter: FLCCC also recommend monitoring your oxygen saturation with a pulse oximeter and to go to the hospital if you get below 94%.
Optional (Editor's Note): Curcumin: 500 mg twice a day (Ref) (Amazon)

The medical evidence to support each drug and nutrient can be found under “Medical Evidence” on the FLCCC’s website.

Quercetin, Zinc and Vitamin C - Dr Zelenko's Protocol for COVID-19

According to Dr. Zelenko, the best over the counter substitute or natural alternative to hydroxychloroquine is quercetin. 

When hydroxychloroquine is not available, Dr. Zelenko recommends the following OTC (over-the-counter) treatment in the early stages of COVID-19 and quercetin as a natural alternative to hydroxychloroquine. He recommends this treatment immediately after you have symptoms.
  • Zinc 50mg 1 time a day for 7 days (PubMed) (Amazon)
  • Quercetin 500mg 2 times a day for 7 days (PubMed) (Amazon
  • Vitamin C 1000mg 1 time a day for 7 days (Amazon)
  • Vitamin D3 5000 IU 1 time a day for 7 days (Amazon)
As a prevention treatment, Dr. Zelenko recommends the OTC (over-the-counter) alternatives to hydroxychloroquine. His prophylaxis protocol for COVID-19 is the following:

What is Zinc?

Zinc is a powerful immune nutrient known for its benefits for providing immune health support and inflammation reduction as well as for improving cold and respiratory symptoms, wound healing, acne reduction, and lowering the risk of age-related diseases. Research on atherosclerosis and diabetes mellitus suggests that zinc deficiency may contribute to low-grade systemic inflammation.

Even more popular at the moment is the role of zinc and the potential benefits against COVID-19. This is probably one of the reasons that's driving the demand on zinc related products. In a ConsumerLab survey of 9,647 people who use dietary supplements shows that the supplements which experienced the greatest growth in popularity in 2020 were those being promoted to prevent or treat infection with SARS-CoV-2, the coronavirus that causes COVID-19. Zinc supplements achieved the highest growth with 13.5% points.

Does zinc help treat COVID 19? In order to answer that question, there are many zinc studies underway and you can review the status of these trials on clinicaltrials.gov. As of March 2021, there are 20 studies that have been launched to investigate the benefits of Zinc against COVID-19.

Are all zinc supplements the same? The zinc supplements in this review are all manufactured by reputable companies that follow Good Manufacturing Processes (GMP), use high quality ingredients, and test for purity and quality.

Here are the best zinc supplements to help you meet your nutritional needs. As everyone has their own set of criteria, the best option for you might be different from another person.

Best Zinc Supplement 2021

1. Zinc Lozenges with Vitamin C - Healthy Immune Support Lozenges with 25mg of Zinc Supplement Per Lozenge + 30mg of Vitamin C - OneDayMD's Best Seller

 

SHOP NOW AT AMAZON (AVAILABLE) - Amazon's Choice for Zinc Lozenges.

  • Nutritionally Supports a Healthy Immune System*
  • Formulated with a perfect balance of 25 mg of Zinc, 30 mg of Vitamin C, 2mg of Vitamin B6, and a Proprietary Blend of Royal Jelly, White Willow Bark Ext., and Slippery Elm Bark Powder
  • Almost TWICE the amount of zinc per lozenge of cold-EEZE zinc lozenges*
  • Fruit Flavored to provide children zinc lozenges without a large amount of added sugars
  • Internally tested and third party tested to ensure purity and potency so you get the highest quality vitamin
  • Made in the USA in a FDA Registered & Inspected Facility, under Good Manufacturing Practices (GMP's)
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

2. NOW Foods Zinc Glycinate Softgels - Best Chelated


SHOP NOW AT AMAZON 

Price: From $11.49

Amazon Reviews: 4.7 out of 5. More than 500 customer reviews.

Chelated zinc is a type of zinc supplement that uses a chelating agent to help your body absorb zinc more easily.

While there are several chelated zinc supplements on the market, one of the best options is NOW Foods’ Zinc Glycinate softgels.

Each softgel contains 30 mg of zinc glycinate — a form of zinc that human and animal studies suggest may be better absorbed than other types of zinc. (Trusted SourceTrusted Source).

All NOW Foods supplements are certified by Underwriters Laboratories and follow GMP to ensure the quality and accuracy of their products. Additionally, these supplements tend to be more affordable than many other high quality brands.

3. Garden of Life Vitamin Code Raw Zinc - Best Vegan Option

SHOP NOW AT AMAZON (available)

Price: $10.49

Amazon Best Sellers: #2 in zinc mineral supplements

Amazon Reviews: 4.8 out of 5. More than 14,500 customer reviews.

While it’s not always obvious, some supplements can contain animal-derived ingredients, making the product unsuitable for vegans.

Some commonly used ingredients that aren’t vegan-friendly include digestive enzymes like lipase, caprylic acid from milk, gelatin, and magnesium stearate, which is often pork-derived.

Garden of Life is a whole-foods-based supplement brand with products that are certified organic and non-GMO verified.

Their Vitamin Code Raw Zinc is a good option for vegans, as it’s third-party tested to ensure the product is vegan, as well as gluten-free.

In addition to providing 30 mg of plant-based zinc, each serving also contains vitamin C, a raw organic fruit and vegetable blend, and live probiotics and enzymes to support healthy digestion.

It’s recommended that adults take one serving of 2 capsules per day with or without meals. For those who have difficulty swallowing pills, the capsules can also be opened to pour the contents into a glass of water or other beverage.

4. Nature's Bounty Zinc 50 mg Caplets 


SHOP NOW AT AMAZON (AVAILABLE)

Price: From $5.21

Amazon Reviews: 4.8 out of 5. More than 50,000 customer reviews on Amazon.com.

About this item:
  • This product is the #1 best seller under the zinc mineral supplements on Amazon Best Sellers and has more than 50,000 customer reviews on Amazon.
  • One vegetarian-friendly caplet a day contributes to carbohydrate, protein, fat and energy metabolism, and helps promote wellness in key areas of reproductive health for men.*
  • Plays a key role in the synthesis of testosterone.*
  • *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.

5. Nature's Bounty Immune 24 Hour +  - Best Zinc Supplement for Seniors


SHOP NOW AT AMAZON (AVAILABLE)

Price: From $29.49

Amazon Reviews: 4.8 out of 5. More than 19,000 customer reviews on Amazon.com.

Zinc dosage for senior: Men over age 60 do not usually meet their recommended daily zinc needs. On average, males in this demographic get 9.4 milligrams per day, slightly less than the recommendation, according to the Office of Dietary Supplements. In some cases, your doctor may suggest taking a daily multivitamin or zinc supplement to further boost your zinc intake. Zinc can be toxic at high doses, causing severe gastrointestinal problems. It is unlikely to get excessive amounts of zinc from your diet, but you can overdose on supplements. 

About this item:
  • Softgels contain Zinc (15 mg per serving daily; 136% of daily value), Vitamin A, C, D3, B6, B12, Biotin, Folate, Panthotenic Acid, Magnesium, Echinacea, Elderberry, Astralagus.
  • THE ONLY VITAMIN C WITH 24-HOUR IMMUNE SUPPORT: Nature's Bounty Immune 24 Hour + contains 1000mg of Ester-C, the only clinically studied Vitamin C with 24-hour immune support. Ester-C lasts up to 2x longer than regular Vitamin C
  • PLUS VITAMIN D & ZINC, WITH ELDERBERRY AND ECHINACEA: Immune 24 Hour + provides Vitamin D, Vitamin A and Zinc for extra immune plus antioxidant support. Also contains Elderberry and Echinacea, plus 9 essential nutrients to help keep you healthy
  • SUPPORTS UPPER RESPIRATORY HEALTH: Highly bioavailable Ester-C can increase Vitamin C levels in the body, which is important for white blood cell function, contributing to the health of the upper respiratory tract
  • NON-GMO FORMULA: Nature's Bounty Immune 24 Hour + is Non-GMO and contains No artificial flavor or artificial sweeteners, no sugar, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish, sodium free
  • RAPID RELEASE SOFTGELS: For adults, Take 2 softgels daily, preferably with a meal.

6. NutriGold Zinc Gold - Best Organic

SHOP NOW AT AMAZON 

Price: $18.38

If you’re looking for an organic zinc supplement, NutriGold’s Zinc Gold is one of the best options out there.

Each capsule contains 15 mg of whole-foods-based zinc that’s derived from an organic sprouted blend, which the supplement claims may be gentler on your stomach.

Additionally, NutritGold’s supplements are certified organic by SCS Global Services, an official partner of the United States Department of Agriculture (USDA) that sets sustainability, quality, and organic standards.

Each product is also third-party tested, as well as non-GMO and vegan certified.

Adults should take 1 capsule daily, or as directed by your healthcare provider.

7. Sandhu's Zinc Quercetin 120 Vegetarian Capsules


SHOP NOW AT AMAZON

Price: $11.39

Amazon Best Sellers: #4 Best Seller in zinc mineral supplements. 4.8 out of 5 overall rating with more than 6,000 customer reviews.
  • Supports immune system health
  • 60 servings per bottle
  • Supports cardiovascular health

Best Quercetin Supplements 2021

8. Now Foods Quercetin with Bromelain (Now Quercetin with Bromelain Amazon)


$30 - $35 > Check Price (available)

A two-pack of top notch bromelain-enhanced quercetin from a giant in the health supplement industry. Reliable quality from a trustworthy brand.

Each capsule contains 400 mg of quercetin and 82.5 mg of bromelain. Do take note that their suggested usage is 2 capsules twice daily. Meaning the total daily dosage of quercetin will be 1,600 mg daily.

Daily value (DV) for quercetin not established.

Now Foods Quercetin supplements contain Bromelain, as some evidence suggests they boost absorption.

For prevention of COVID-19, the FLCCC recommends 250 mg daily for prevention and the Zelenko protocol recommends 500 mg daily for prevention. If you wish to stick to the dosage which is within the range of the FLCCC - Zelenko protocols; that would be 250 mg to 500 mg daily i.e. 1 capsule of Now Foods Quercetin per day.

BestReviews.com: Not suitable for those with pineapple allergies.

Amazon Best Sellers: #1 Best Seller in Bromelain Nutritional Supplements. 4.7 out of 5 overall rating with more than 5,000 customer reviews.

Our Take: If you are looking for best value and are taking it on a long term basis, this would be your choice.

9. Thorne Research Quercenase  


Price: $38 > Check Price on Amazon 

Quercenase is a combination of quercetin phytosome and bromelain. Quercetin phytosome is a new food-grade lecithin-based formulation of quercetin, was developed to overcome the low bioavailability hurdle of quercetin. Phytosome complexes are created by a patented process that binds a botanical extract to a phospholipid (phosphatidylcholine), which are key components of every cell membrane.

Each capsule contains 250 mg of quercetin phytosome and 100 mg of bromelain.

BestReviews.com: Pricier than many similar products on the market

Amazon Best Sellers: #11 Best Seller in Flavonoid Vitamin Supplements. 4.7 out of 5 overall rating with more than 390 customer reviews.

Our Take: If you are looking to buy from a reputable brand, this would be your choice.

10. Pure Encapsulations Quercetin



Our Take: A hypoallergenic, pure quercetin supplement suitable for those with tendency of allergies.

BestReviews.com: Dosage is somewhat low and the pills are relatively expensive.

Amazon Best Sellers: #4 Best Seller in Flavonoid Vitamin Supplements. 4.8 out of 5 overall rating with more than 600 customer reviews.

11. Amazing Formulas - Quercetin 500 Mg



Amazon Best Sellers: #1 Best Seller in Flavonoid Vitamin Supplements. 4.7 out of 5 overall rating with more than 13,000 customer reviews.
  • Quercetin is a flavonoid (plant pigment) naturally found in fruits and vegetables. It is found in many foods, such as red wine, onions, green tea, apples, berries etc. It known for its Anti-oxidant and Anti-Inflammatory Properties. Amazing Nutrition Quercetin 500 Mg is offered in Veggie Capsule to suit most diet preferences
  • Anti-oxidant properties of Qurecetine Supports Healthy Ageing, Cardiovascular Health, and Immune Health. It helps to reduce the damage and irritation caused by free radicals
  • Anti-Inflammatory properties of Quercetin helps to lower the release of histamines, a compound that is released by cells in response to allergic and inflammatory reactions. Subsequently helping to lower pains and discomfort related to Inflammation.
  • All Amazing Nutrition products are manufactured in accordance with Good Manufacturing Practices (GMP), among the highest standards in the world.

12. Mt Angel Vitamins Quercetin Zinc - Best Immune Support Supplement 


FORTIFIED FUNCTION – Sick of stuffy, sneezy, seasonal illnesses? Fight flare-ups with Mt. Angel Vitamins’ quercetin supplement! This nutrient blend helps boost better health so you can feel your best!

OVERALL AID – Bolster your body AND mind! Quercetin with vitamin C and zinc are proven not only to provide immune support but also to improve metabolism, circulatory supporty, and cognitive clarity!

BREATHE & BOUND – Revive your vitality! By fostering cellular functioning, your zinc quercetin capsules’ antioxidants enhance respiratory health and energy levels so you can enjoy activities!

TAKE IT EASY – Support, meet simplicity. To enjoy extra defense, take 1 of your quercetin with bromelain and zinc capsules twice daily. Bursting with 300 capsules, your bottle lasts longer than most brands’.

Our Take: Quercetin works best when taken with vitamin C and Bromelain, as vitamin C helps activate it and bromelain helps with the absorption. That’s why many quercetin supplements contain vitamin C or bromelain, as some evidence suggests they boost absorption.

Ratings4.7 out of 5 - more than 1000 global ratings

ReviewsMy husband read the Swiss protocal for Covid 19 preventative and this has it all. So far so good no problems. No bad taste easy to swallow, our 12yr old son even has no problem.


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