6 Best Quercetin Supplements of 2021: Benefits, Dosage and Side Effects
Some doctors are advocating its use against SARS-CoV-2 (COVID-19), in combination with vitamin C, noting that Quercetin and Vitamin C have synergistic effects.
There are many quercetin supplement brands available out there. Which one should you buy? Why do we provide so many options below? Many of the brands do go out of stock on Amazon (this article needs to be updated from time to time). You may also have your own set of purchasing criteria and it's likely to be different for different individuals. For example, you might have a preference for liquid form or powder form or capsule form instead of tablet.
Check out below the best quercetin supplements available online. Where to buy quercetin supplement? Order via the links below and it will be delivered to your designated address by Amazon.
Best Quercetin Supplements 2021
1. Now Foods Quercetin with Bromelain
$27 - $35 > Check Price
2. Thorne Research Quercenase
BestReviews.com: Pricier than many similar products on the market
Amazon Best Sellers: #11 Best Seller in Flavonoid Vitamin Supplements. 4.7 out of 5 overall rating with more than 390 customer reviews.
3. Pure Encapsulations Quercetin
4. BlueBonnet Super Quercetin
5. Natural Factors Bioactive Quercetin
Dosage of quercetin is somewhat low (as compared to other brands) in each capsule. However, Natural Factors claims the quercetin is more bioavailable, which means your body gets a strong dose regardless. Each capsule contains 167 mg of EMIQ and 50 mg of vitamin C. Natural Factors claims their formula will provide year-round protection while supporting a healthy inflammatory response and maintaining good sinus and upper respiratory function.
6. Mt Angel Vitamins Quercetin Zinc - Best Immune Support Supplement
Benefits of Quercetin Supplements
You may already get a small amount of quercetin in your normal diet: quercetin is found in onions, kale, tomatoes, broccoli, asparagus, berries, red wine, citrus fruits, cherries, and tea. Many people also take quercetin in supplement form.
In fact, it’s estimated that the average person consumes about 10 to 100 mg of quercetin per day through a normal diet. Quercetin is one of the most abundant flavonoids in the human diet.
Quercetin is a pigment that belongs to a group of plant compounds called flavonoids (also known as bioflavonoids). Flavonoids are naturally present in fruits, grains, teas, and wine. Researchers have linked flavonoids to a variety of benefits, including a reduced risk of heart disease, cancer, and degenerative brain disorders.
What does science have to say about quercetin? Can quercetin really fight inflammation and reduce the risk of disease? Let’s dive into the science behind quercetin.
Quercetin has been shown to reduce inflammation in multiple studies. In this 8 week study involving 50 women with rheumatoid arthritis, participants took 500mg of quercetin per day or a placebo. The quercetin group reported less early morning stiffness, morning pain, and after-activity pain.
Early studies on quercetin and inflammation are promising, although more large scale human studies need to be performed to verify these benefits.
There’s evidence that quercetin reduces allergy symptoms. Researchers believe quercetin’s anti-inflammatory effects may relieve allergy symptoms.
This study published in Molecules in 2016, for example, found that quercetin could be effective for treating the anaphylactic (allergic) reaction in someone with peanut allergies. A similar study from 2006 concluded that quercetin was a “safe, natural therapy that may be used as primary therapy or in conjunction with conventional methods” for blocking allergies.
It’s possible that quercetin has the same anti-allergy effect in humans, although more research needs to be done.
There’s also some evidence that quercetin has cancer-fighting properties. Researchers believe quercetin can fight cancer cells with its powerful antioxidant properties.
In 2015, researchers reviewed available test tube and animal studies on quercetin and prostate cancer. After reviewing available evidence, researchers found that quercetin suppressed cell growth and induced cell death in prostate cancer cells.
This study published in 2017 in Oncology Reports took things a step further, finding that quercetin induced cancer cell death in nine types of cancer, including prostate cancer, colon cancer, and breast caner.
In another 2017 study, researchers gave quercetin to mice with tumors. Researchers found that mice in the quercetin-treated group showed delayed tumor growth, no significant changes in daily behavior, significantly better survival ratings, and increased rates of cell death.
Quercetin may also target bladder cancer. In 2016, researchers published a landmark study in the American Journal of Cancer Research. Researchers analyzed quercetin’s effect on cancer cells in a test tube. They concluded, “We are the first to show that quercetin displays potent inhibition on bladder cancer cells via activation of AMPK pathway.”
Early research on the cancer-fighting benefits of quercetin is promising, although more research needs to be performed to verify these effects in humans.
Other evidence suggests quercetin lowers your risk of chronic brain disorders, including Alzheimer’s and dementia.
In this study published in Neuropharmacology in 2015, researchers gave quercetin to mice with Alzheimer’s, injecting them with quercetin every two days for three months. By the end of the study, the injections had reversed several markers of Alzheimer’s, and the mice performed much better on learning tests.
In a separate study published in 2018, researchers gave mice with Alzheimer’s a quercetin-rich diet. Researchers found the diet improved brain function in mice with early-middle stage Alzheimer’s, although it had no significant effect on middle-late stage Alzheimer’s.
You may have heard that coffee is linked to a reduced risk of Alzheimer’s. There’s certainly some research to back that claim up. However, recent research has suggested that quercetin (not caffeine) is the primary compound in coffee responsible for protective effects against Alzheimer’s.
Some people use quercetin to reduce blood pressure and improve other measurements of cardiovascular health. High blood pressure raises your risk of heart disease, which is the leading cause of death in the United States. Approximately 1 in 3 American adults have high blood pressure.
Research suggests that quercetin reduces blood pressure levels. In this study published in 2002, researchers found that quercetin exhibited vasodilator effects, widening blood vessels and reducing blood pressure.
Multiple studies on humans have suggested similar benefits. Researchers reviewed nine human studies involving 580 people. After reviewing available evidence, researchers found that taking more than 500 mg of quercetin supplement per day reduced systolic and diastolic blood pressure by 5.8mm Hg and 2.6 mm Hg, respectively. In other words, quercetin was shown to significantly improve blood pressure readings.
Some people take quercetin for its anti-aging effects. Antioxidants and anti-inflammatories – including quercetin – seem to have powerful anti-aging benefits. One study on young mice found that quercetin reduced mortality and extended lifespan. Another study from 2017 on human cells in test tubes found that quercetin reduced aging markers, with researchers concluding there was “anti-aging potential” for quercetin.
Others take quercetin supplements to improve endurance and exercise performance. This 2011 study reviewed 11 quercetin studies involving 254 human subjects and found that quercetin provided a statistically significant benefit in human endurance exercise capacity (VO2 max) and endurance exercise performance, although the effect “is between trivial and small”.
Finally, some diabetics take quercetin to help manage blood sugar. This study from 2019 found that taking 500mg of quercetin per day significantly reduced fasting plasma glucose (FPG) levels, suggesting that quercetin helped control fasting blood sugar. This study in 2019 found similar results, finding that quercetin lowered serum glucose levels at doses of 10, 25, and 50mg per kg.
Some suggest that quercetin could treat the COVID-19 coronavirus. Quercetin was shown to be effective against SARS, the Ebola virus, and the Zika virus. This 2019 study by researchers in Korea found that quercetin and other flavonoids may inhibit the proteolytic activity of SARS-CoV 3C-like protease, creating an antiviral effect. Research on the coronavirus and quercetin is ongoing, and it’s unclear if quercetin will have similar antiviral effects against COVID-19. To be clear, there’s no evidence suggesting that quercetin treats, prevents, or manages the COVID-19 coronavirus, although research is ongoing.
DosageMost quercetin studies use a dosage of around 500mg per day, although some studies use a dosage of 500mg taken twice per day.
Most supplements have a similar dosage, offering 500mg to 1,200mg of quercetin per serving.
In some studies, researchers have given participants up to 5,000mg of quercetin per day with no reported side effects.
Quercetin has poor bioavailability. You might take a 1,200mg quercetin supplement, but your body only absorbs a small percentage of it. That’s why many quercetin supplements contain vitamin C or bromelain, as some evidence suggests they boost absorption.
There’s also some evidence that quercetin has a synergistic effect when combined with other flavonoid supplements. That’s why some quercetin supplements contain resveratrol, catechins, genistein, and other flavonoids.
Quercetin Side EffectsQuercetin is generally recognized as safe. It’s found in many fruits and vegetables, and most people will experience no side effects when taking normal dosages of quercetin.
There have been few reported side effects for quercetin supplements.
In some studies, large doses of quercetin (over 1,000mg) were linked with headaches, digestive issues, and tingling sensations. However, these symptoms were mild and uncommon.
Quercetin from food sources is safe for pregnant and breastfeeding women to take. However, there’s limited research on quercetin supplements in pregnant or breastfeeding women.
There’s no evidence that quercetin interacts with any drugs in a significant way. However, you should talk to your doctor before taking quercetin, especially if you are taking antibiotics or blood pressure medication.
Frequently Asked Questions About QuercetinThis section will help to answer some of the most commonly asked questions about Quercetin.
What are the best foods for quercetin?
A: Capers, peppers (yellow and green), onions (red and white), shallots, asparagus, cherries, tomatoes, red apples, red grapes, broccoli, kale, red leaf lettuce, cranberries, blueberries, raspberries, green tea, black tea, and coffee are all excellent foods for quercetin.
That’s why the supplements may include other compounds, such as vitamin C or digestive enzymes like bromelain, as they may increase absorption.
Additionally, some research indicates that quercetin has a synergistic effect when combined with other flavonoid supplements, such as resveratrol, genistein, and catechins.
A: The average person gets 10 to 100 mg of quercetin per day through normal dietary sources. This can vary greatly. Carefully track your diet over an extended period to figure out if you have a dietary deficiency of quercetin.
How much quercetin should you take per day?
A: Researchers typically use a dose of 500 mg of quercetin per day in supplement form. Most quercetin supplements contain between 500 and 1200 mg of quercetin, although this can vary. Check out the nutritional label for your quercetin supplement to be sure.
Does quercetin help allergies?
A: Many people take quercetin supplements to avoid allergy symptoms. There’s evidence that quercetin has powerful anti-allergy benefits, although more research needs to be done.
Q: Does quercetin fight cancer?
A: Early research in test tube and animal models shows that quercetin may have cancer-fighting properties. While these findings are promising, more large scale human studies need to be performed. Research is not definitive. Consult your physician before using any supplement to improve your cancer.
Q: Does quercetin reduce the risk of Alzheimer’s?
A: Studies show that quercetin may reduce the onset of Alzheimer’s, particularly in the early and middle stages of the condition. However, studies have mostly been performed on mice and test tubes – not in humans.
Q: What are other names for quercetin?
A: Quercetin goes by a number of different names. You might see quercetin supplements labeled as bioflavonoid concentrate, bioflavonoid extract, or citrus bioflavonoid, for example.
Q: Can quercetin help you recover after exercise?
A: Some studies show that quercetin boosts recovery after exercise. In some small studies, athletes taking quercetin after exercise had faster recovery than a control group. Researchers believe quercetin reduces oxidative stress and post-exercise inflammation, helping your body recover.
Q: What are the side effects of quercetin?
A: Most people experience no side effects from quercetin, and any side effects tend to be mild. Quercetin side effects include tingling and numbness, headache, and nausea. Your chance of experiencing side effects increases at higher dosages (over 1,000mg).
Q: Why do so many quercetin supplements contain bromelain?
A: Bromelain is a naturally occurring, protein-digesting enzyme found in the stem of the pineapple. Bromelain seems to boost the absorption of quercetin by inhibiting inflammatory chemicals called prostaglandins. Bromelain may also decrease inflammation on its own.
Q: What’s the difference between rutin or glycosidic quercetin?
A: Quercetin is found in two forms, including in rutin or glycosidic form. Quercetin glucosides, such as isoquercitrin and isoquercetin, seem to be much more bioavailable and more quickly absorbed than quercetin aglycone or quercetin glycosides, such as rutin (quercetin rutinoside).
Q: Can you overdose on quercetin?
A: In one study, researchers gave participants 2,000mg to 5,000mg of quercetin per day with no adverse effects or signs of toxicity reported. Generally, quercetin is safe to take even in high doses, although you may experience mild side effects like nausea, digestive issues, and headaches at high doses. Excessively high doses of quercetin could lead to kidney problems.
Q: How much quercetin should you take for hay fever?
A: Experts recommend taking 400mg of quercetin twice a day between meals for hay fever. Also consult your doctor to help provide a more comprehensive and effective treatment for hay fever.
Q: Can children take quercetin?
A: Most studies suggest that it’s safe to give quercetin to your child, although you should use only half the dose you'd use on an adult. Talk to your pediatrician before giving any quercetin to your child.
Q: How does quercetin manage allergy symptoms?
A: Studies have shown that quercetin stabilizes mast cells that release histamine. Histamine is the principal mediator of reactions to pollen and other allergies. This makes quercetin a natural antihistamine. Many people use quercetin to treat symptoms of hay fever, including runny nose, watering eyes, and itching.
Q: Can you take too much quercetin?
A: You should start with a quercetin dosage of around 500mg per day to assess your tolerance. However, researchers have given participants up to 5,000mg of quercetin per day with few reported side effects. Look for symptoms like upset stomach and diarrhea. Excessively high doses of quercetin could lead to kidney problems.
Q: Who should not take a quercetin supplement?
A: Quercetin appears safe for anyone to take when used in normal dosages. However, there’s limited research on how quercetin supplements affect women who are pregnant or breastfeeding. People with high blood pressure, or anyone taking blood pressure medication, may also want to take to their doctor before taking a quercetin supplement.
Q: Can you take a quercetin supplement with a pineapple allergy?
A: If you’re allergic to pineapples, you should avoid quercetin supplements with bromelain. Bromelain, an enzyme in pineapples, is added to quercetin supplements to boost bioavailability. Overuse of bromelain can create problems for consumers.
Q: Does quercetin work for anti-aging?
A: Several studies have examined the effect of quercetin on aging. Quercetin is rich with anti-inflammatories and antioxidants, which could make it a powerful anti-aging compound.
Q: Does quercetin help asthma?
A: Quercetin may help asthma by relaxing smooth muscles lining the airway, improving airway flow.
Q: What’s better – quercetin tablets, capsules, powders, or liquid?
A: Quercetin liquid claims to be more bioavailable than other sources of quercetin. You take the liquid sublingually (underneath your tongue). However, limited research shows quercetin capsules or powders are more effective, and all forms of quercetin are absorbed poorly by the body.
Q: Where does quercetin come from?
A: Most supplement companies use various plant or vegetable-based sources of quercetin. Check the label.
Q: Can you get citrus-free quercetin?
A: Some quercetin supplements are specifically marketed as citrus-free, making them ideal for those with citrus sensitivities. Read the label or official product website for your supplement to be sure that it is actually citrus-free.
Q: Does quercetin help with diabetes?
A: There’s some evidence that quercetin helps with diabetes, helping your body manage blood sugar levels during fasting. However, more research needs to be done to verify these benefits.
Q: Is quercetin non-GMO?
A: Quercetin supplements are generally labeled non-GMO. Check the label to verify your quercetin supplement is not made from genetically modified ingredients.
Wrapping It UpQuercetin is a bioflavonoid with potent antioxidant and anti-inflammatory effects. Many take quercetin supplements daily to support various body systems.
Some people take quercetin supplements for allergies. Others take it to boost the immune system. Others take quercetin for general anti-aging or health and wellness.
Early research on quercetin is promising, and new human studies are released every year validating certain quercetin benefits.
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- Nature's Bounty Vitamin C - 1,000 mg > One caplet twice daily (Amazon)
- Now Foods Quercetin - 400 mg > One capsule daily (Amazon)
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- Nature's Bounty Zinc 50 mg/day > One caplet daily (Amazon)