9 Best Quercetin and Bromelain Supplements: Benefits and Reviews 2023
What Is Quercetin?
While the best way to get quercetin is through your diet, it also is available in supplement form, as pills or capsules. Sometimes, quercetin in supplement form is packaged with bromelain, an enzyme found in pineapples, because both have anti-inflammatory properties (Quercetin & Bromelain for inflammation). Most dietary supplements contain a chemical compound, aglycone, which is the free form of quercetin.
When looking for and using quercetin supplements, it’s important to maintain a nutritious, balanced diet with fiber and healthy fats in it, as research shows that accumulation of quercetin in the body is dependent on “factors such as glucose moieties, solubility, human factor, vitamin C status and food matrix.”
Specifically, research also says that quercetin supplementation is best achieved when consumed with a fat-enriched diet.
There are foods high in quercetin that you can add to your diet. Arguably, red onions are some of the most potent sources of quercetin; one study found that absorption of onion-derived quercetin was 52% compared to only 24% in supplement form. In fact, onions can give you three times the amount of quercetin than you’d get from apples. Other food sources that are high in quercetin include:
- Organically grown apples, grapes and tomatoes
- Dark cherries and dark berries like blueberries, blackberries and bilberries (eaten in moderation)
- Cocoa, unsweetened
- Hot green chili peppers
Benefits of QuercetinQuercetin has been linked to the following health benefits:
- Possessing anti-inflammatory, antioxidant properties that can help combat certain diseases. One study found that 500 mg of quercetin a day could improve symptoms of rheumatoid arthritis.
- Helping prevent cancer cell growth from breast, colon, prostate, endometrial and lung.
- Counteracting allergic reactions and helping with immune responses.
- Helping to prevent osteoporosis
- Addressing cognitive decline, including Alzheimer’s and dementia.
- Assisting in control of blood pressure. A study in 2002 found that quercetin can have vasodilator effects.
- Potentially helping to lower blood sugar levels. One study found that dosages of 500 mg per day “significantly reduced” fasting glucose levels.
What is Bromelain?Bromelain, or pineapple extract, is a compound made up of proteases normally found in pineapples. Although it is widely known for its ability to aid in digestion and protein breakdown, its use far transcends these functions and can actually offer a lot more. The good news is that it's available in the market as a supplement and as an aid for disease treatments.
The history of bromelain is heavily linked to pineapple because it is the only known major source for this group of enzymes. First discovered in 1891 by chemist Vicente Marcano and then subsequently elaborated by Russell Henry Chittenden, another chemist, bromelain was first called "bromelin," and described as the "proteolytic ferment of pineapple juice."
Its first primary source was the pineapple fruit, before it was discovered that the mature pineapple stem had much more concentrated bromelain content.
Through the years after its discovery, the production of bromelain has broadened. Its commercialization has led manufacturers into developing faster extraction techniques for large-scale production and purification. Today, bromelain supplements are used for numerous health approaches.
These uses have been observed to be dependent on the time when it is taken. For example, if taken after a meal, bromelain may help promote better digestion and absorption, but when taken on an empty stomach, it can help alleviate inflammation.(Daily Mail)
Benefits of BromelainAs a protease enzyme, the primary benefit bromelain has is improving protein absorption. However, bromelain has been widely used to promote healing and assist in the treatment of numerous diseases. For example, if you're suffering from chronic inflammation or from sports injuries, consider taking bromelain supplements to help your body recover. Other bromelain benefits that you'll get from this supplement include:
• Reduces inflammation and swelling — Bromelain may help alleviate symptoms of osteoarthritis and rheumatism. It's also used to help in sprain and strain recovery by reducing swelling and promote tissue healing. For people who are currently on arthritis medications, consider switching to bromelain for a more natural alternative.
• Improves immune function — Studies show that bromelain promotes a healthy immune system by regulating numerous inflammatory proteins during periods of cellular stress.
• Speeds up wound healing — The use of bromelain post-surgery has been observed to promote soft-tissue healing and reduce bruising. Patients who took bromelain also had shorter wound healing time compared to patients who did not.
• Relieves sinusitis symptoms — Sinusitis refers to the inflammation of the inner lining of the sinuses, which is usually caused by infections, nasal problems or allergies. Bromelain is a known supplement for relieving sinusitis symptoms. Together with quercetin, bromelain can help alleviate sinus inflammation, with quercetin functioning as an antihistamine.
• Promotes blood flow — Bromelain helps in promoting healthy blood flow by reducing platelet aggregation in the arteries and lowering the chances of clots forming. This may lower your risk of developing atherosclerosis and other cardiovascular diseases.
There are also claims that bromelain can help induce menstruation by softening the uterine lining. The increased blood flow also supposedly helps in the prevention of menstrual cramps.
Because of the impressive components of bromelain, it's not surprising that it's been utilized in treating or reducing the severity of disease symptoms. While it is usually prescribed or recommended for patients who have undergone surgery or people suffering from chronic sinusitis, bromelain can also be used in other ways. These include:
• Topical application for burns — Studies suggest that bromelain can help remove dead skin cells from third degree burns and assist in burn healing in first and second degree burns. For severe burns, do not apply any bromelain ointment without a physician's supervision.
• Indigestion and heartburn — Taking bromelain has been known to assist in easing indigestion and bloating, especially when taken with other supplemental enzymes.
• Soothing balm for insect bites and stings — Applying bromelain directly to insect bites and stings may lessen inflammation and discomfort.
• Meat tenderizer — Pineapple has been used in cooking to soften meats. Today, bromelain is sold in powder form as a meat tenderizer and is usually combined with papain, an enzyme found in the papaya plant. In fact, bromelain is such a strong meat tenderizer that chefs and cooks claim it can turn meat into mush if left marinated for longer periods of time.
Quercetin with Bromelain for InflammationStudies have shown that systemic enzymes for inflammation (like bromelain) combined with quercetin, produce greater anti-inflammatory benefits than either one used alone. Thus, the combination of bromelain and quercetin is ideal for effectively inhibiting the inflammatory response in both acute and chronic inflammatory conditions.
Since bromelain and quercetin are recommended to be taken together for maximum anti-inflammatory benefit, formulas that contain both ingredients are ideal. This also simplifies the dosing schedule and reduces the total number of capsules needed to be taken throughout the day.
Quercetin with Bromelain for Allergies
Quercetin with Bromelain for Hives
In many cases, hives are an acute (temporary) problem that may be alleviated with allergy medications. Most rashes go away on their own. As with any allergic reaction, if hives are accompanied by difficulty breathing or swallowing, this can be a sign of a much more severe and serious anaphylactic reaction. This requires immediate emergency medical attention to treat. Please see your doctor and go to the nearest 24 hr emergency clinic or hospital immediately.
Dr Deborah Gordon recommends trying a food elimination diet to pinpoint the source of the problem. Thus, if you get rid of the source, you won’t have to worry about treating the hives.
Antihistamine drugs also stop the release of the histamines that cause the hives in an allergic reaction. However, people who suffer from chronic hives don’t usually want to take medication for months or years if they don’t have to.
For this reason, some allergy sufferers turn to natural alternatives such as quercetin; that works by stabilizing the membranes of cells that release histamine. This often helps brings inflammatory and allergic reactions under control. You can buy quercetin products in natural foods stores or Amazon. The best form is a coated 400 mg tablet, taken twice a day between meals; as recommended by Dr Andrew Weil. It can take six to eight weeks of continuous use for quercetin to build up to therapeutic levels in the body.
Quercetin with Bromelain for Sinusitis
Acute sinusitis - an infection that is often triggered by the flu or cold. The flu or cold virus attacks your sinuses causing them to swell and become narrow. Your body responds by producing mucus. When the sinuses become blocked and are filled with mucus, viruses, fungi or bacteria can grow and cause infections that cause pressure and headache.
Chronic sinusitis - an infection that lasts for more than 3 weeks and can continue indefinitely if not treated. It is often caused by allergies, fungal infections or weakened immune system.
Quercetin has amazing anti-inflammatory and anti-oxidant effects. Since bromelain and quercetin are recommended to be taken together for maximum anti-inflammatory benefit, formulas that contain both ingredients are ideal.
Quercetin with Bromelain for Weight Loss
These inconsistent findings from the studies maybe are due to the difference in the range of fitness of the subjects, differences in research design, different methods in the preparation of quercetin extract, etc. In order to assist you in doing your own research, let's dive into some relevant studies and reviews.
Therefore, consuming it may help people increase their activity throughout the day and delay fatigue. Plus, this can lead to expending more energy during workouts, thus burning more calories.
Dr Josh Axe also adds that some athletic supplements contain quercetin because some people believe that is increases endurance and athletic performance.
It was also discovered that consumption of 500 mg of quercetin twice a day increased the VO2 max (the maximum amount of oxygen that is utilised by an individual) in untrained individuals as a result of an increase in mitochondrial biogenesis.
This enhancement in fitness without exercise training can be used in disease prevention such as obesity.
Inflammation vs allergies vs hives vs sinusitis?
Allergies are triggered by allergens (an allergen is normally a foreign substance that can cause an allergic reaction) leading to inflammation. However, inflammation can also be triggered not only by allergens but also by bacterial or viral infections.
Quercetin and Bromelain Side EffectsAccording to WebMD, quercetin is POSSIBLY SAFE for most people when taken by mouth on a short-term basis. Quercetin has been safely used in amounts up to 500 mg twice daily for 12 weeks. It is not known if long-term use or higher doses are safe.
When taken by mouth, quercetin could cause headache, stomach upset and tingling of the arms and legs. Very high doses might cause kidney damage.
Those who are taking blood thinners or have concern about the adverse effects of bromelain, should consider quercetin supplements that do not contain bromelain.
Very high doses of quercetin (above 1 g), were found to have adverse effects on kidney functioning.
Quercetin and Bromelain Supplements on Amazon
1. Now Foods Quercetin with Bromelain
#1 in Bromelain Nutritional Supplements on Amazon
4.7 out of 5 overall rating with more than 17,000 customer reviews.
2. Thorne Research Quercenase
- Promising Effects of 3-Month Period of Quercetin Phytosome® Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study (Life, Jan 2022)
- A Randomised Controlled Trial of 152 outpatients with COVID-19 in Pakistan, 76 treated with quercetin phytosome, showed lower mortality, ICU admission, and hospitalization with treatment (International Journal of General Medicine, May 2021)
BestReviews.com: A potent, science backed formulation by a brand known for quality that is made with the purest ingredients for maximum efficacy. However, it is relatively pricier than many similar products on the market.
Amazon Best Sellers: 4.8 out of 5 overall rating with more than 200 customer reviews.
Our Take: If you are looking to buy from a reputable brand, this would be your choice.
3. MoxyVites Quercetin 500mg with Bromelain Supplement, Bioactive Phytosome Complex
4. Forest Leaf Quercetin, Bromelain, Stinging Nettle, Vitamin C
- Advanced Sinus and Allergy Supplement
- Natural Vegetable Capsules
- Non GMO, Dairy, Gluten, Egg and Nut Free
- Every pill contains stinging nettle leaf extract.
- All of its products and pills are tested for maximum absorption.
- 45 servings per bottle, 200mg of vitamin C per serving.
Vitamin C 200mg, Quercetin 500mg, Stinging Nettle Leaf 500mg, Bromelain 150mg, Vegetable Cellulose (capsule), Microcrystalline Cellulose, Magnesium Stearate and Silicon Dioxide
5. BlueBonnet Super Quercetin
Amazon Best Sellers: #21 Best Seller in Flavonoid Vitamin Supplements. 4.8 out of 5 overall rating with more than 190 customer reviews.
Our Take: If you are looking for a potent antioxidant blend, this would be suitable for you.
6. Whole Food Quercetin Plus
- Organic Whole Foods
- Immune, Cardiovascular & Respiratory System Support
- Natural Antioxidant
- Vegan, Non-GMO
- 180 Caps, 90 servings
-Immunity supporting properties, improves healthy seasonal immune system function, and reduces inflammation.
- May help improve your daily health by aiding exercise performance, improving digestion, helping respiratory health, give your immune system the boost it needs, and enhance cognitive function.
- FREE from GMO, Alcohol, Preservatives, Soy Lecithin, Gelatin, Dairy, Sugar, Gluten, Shellfish, Nuts, Wheat, Stearates, Silicon Dioxide, fillers, Artificial Ingredients.
- Manufactured in the USA. Made in a GMP-certified facility in the USA. Third-party tested.
Quercetin 500 mg + 175 mg of Organic Whole Food Quercetin Blend(4 Organic Whole Food Quercetin source ingredients) + 15 mg of Zinc Picolinate + 200 mg of Bromelain from Pineapple + 100 mg of Organic Ginger Root + 125 mg of Vitamin C from Organic Acerola Cherries + 100 mg of Citrus Bioflavonoids from Organic Orange & Organic Lemon
Been taking these for a few weeks and no adverse effects so far. I’m highly sensitive to a lot of supplements—these seem to be pretty high quality. I like the fact they are whole food, non-gmo, and vegan.
7. Natural Factors Bioactive Quercetin
Dosage of quercetin is somewhat low (as compared to other brands) in each capsule. However, Natural Factors claims the quercetin is more bioavailable, which means your body gets a strong dose regardless. Each capsule contains 167 mg of EMIQ and 50 mg of vitamin C. Natural Factors claims their formula will provide year-round protection while supporting a healthy inflammatory response and maintaining good sinus and upper respiratory function.
Amazon Best Sellers: #25 Best Seller in Flavonoid Vitamin Supplements.
Ratings: 4.8 out of 5 - more than 500 global ratings.
Our Take: Best Quercetin for Bioavailability
8. Vitaraw Quercetin, Zinc, Bromelain, Vitamin C, Vitamin D3
9. Doctor's Best Quercetin Bromelain
- 180 Veggie Caps
- Bromelain 3000 GDU per capsule, has 500 Mg of Quercetin with 250 Mg Bromelain for a Serving size of 2 Capsules
- Quercetin and Bromelain enhances each other's antioxidant and anti-inflammatory potential. Quercetin is a bioflavonoid that has potent antioxidants while bromelain works as protein-digesting enzyme. Bromelain helps increase your body’s absorption and use of Quercetin.
- Helps support immune health, heart health, joint comfort, healthy digestions, respiratory health and inflammatory response.
- Quercetin helps ensure appropriate immune response, inhibits formation of free radicals and promotes circulatory health in part by supporting the integrity of small blood vessels.