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7 Best Cetylpyridinium Chloride Mouthwash Brands 2025

By Dr Frank Yap, MD
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A meta-analysis of 3 studies (C19early 2025) concluded that CPC (CetylPyridinium Chloride) may significantly lower risk with  viral clearance . One study shows significant benefit. Meta analysis using the most serious outcome reported shows 83% [6‑97%] lower risk . Results are consistent with early treatment being more effective than late treatment. A study, published in Nature ( Takeda 2022 ) concluded that CPC (CetylPyridinium Chloride) may inhibit SARS-CoV-2 infection even at lower concentrations. Another team of international scientists has also demonstrated the usefulness of cetylpyridinium chloride-containing mouthwashes in inhibiting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and reducing the risk of viral transmission. The study is published in the Journal of Medical Microbiology (2022). A scientific review, published in the  Journal of Formosan Medical Association  (2022) also concluded that mouthwash containing CPC shows potential fo...
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8 Best Vitamin D3 and K2 Supplements 2025: Benefits, Reviews and Prices

By Dr Frank Yap, MD
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Most people in the United States consume less than recommended amounts of vitamin D . An analysis of data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 4.3 mcg in men, 3.8 mcg in women, and 5 mcg (200 IU) in children aged 2–19 years ( NHANES 2017 - 2018 ). What Is Vitamin D? Vitamin D is a fat-soluble vitamin, meaning that it dissolves in fats and oils and can be stored in your body for a long time. Vitamin D is important to the body in many ways. It helps the body absorb calcium from food and supplements. Muscles need it to move, for example, nerves need it to carry messages between the brain and every body part, and the immune system needs vitamin D to fight off invading bacteria and viruses. Together with calcium, vitamin D also helps protect older adults from osteoporosis. Vitamin D is found in cells throughout the body. Vitamin D Market Size The Global Vitamin D Market size was ...
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Ivermectin and Fenbendazole in the Treatment of Psoriasis? A Case Series of 13 Patients (2025)

By Dr Frank Yap, MD
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Abstract Psoriasis is a chronic autoimmune condition affecting approximately 7.5 million individuals in the United States, with significant economic, physical, and psychological burdens. This case series reports on 13 patients who experienced notable improvements in psoriasis symptoms following treatment with ivermectin and/or fenbendazole, antiparasitic agents repurposed for this indication. Cases were derived from self-reported testimonials shared on social media platforms. Treatment durations ranged from 3 days to 3 months, with dosages varying between 6 mg ivermectin twice daily and combinations with fenbendazole. Rapid resolution of skin lesions was observed in most cases, with some achieving near-complete clearance. While these anecdotal reports suggest potential therapeutic efficacy, controlled clinical trials are warranted to validate these findings and elucidate underlying mechanisms. Introduction Psoriasis is a chronic inflammatory disorder characterized by hyperproliferation...
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Peter Attia, MD: How to Detect Cancer Early - Before it Spreads

By Dr Frank Yap, MD
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Cancer is the 2nd leading cause of death in the U.S. and Dr. Peter Attia joins MedCram to explain optimizing cancer screening using various techniques: timing, imaging (full body MRI, etc.), liquid biopsies, and more. Peter Attia, MD is the founder of Early Medical, a medical practice that applies the principles of "Medicine 3.0" (discussed in this interview) to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan. Dr. Attia is the host of the popular medical podcast called The Drive, and the author of the #1 New York Times Bestseller, Outlive: The Science and Art of Longevity. Dr. Peter Attia received his medical degree from Stanford, trained for five years at the Johns Hopkins Hospital in general surgery, and spent two years at the National Institutes of Health as a surgical oncology fellow at the National Cancer Institute. Interviewer: Kyle Allred, Physician Assistant, Producer, and Co-Founder of MedCram.com. Topics...
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Isoquercetin vs Quercetin vs Quercetin Phytosome 2023: What's the Difference?

By Dr Frank Yap, MD
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Quercetin is a type of flavonoid present in many fruits, vegetables, and grains. It’s one of the most abundant antioxidants in the diet and plays an important role in helping your body combat free radical damage, which is linked to chronic diseases. In addition, its antioxidant properties may help reduce inflammation, allergy symptoms, and blood pressure. Isoquercetin vs Quercetin Quercetin and isoquercetin are both natural plant flavonoids. Quercetin is an aglycone, meaning that it lacks a glycoside side chain. In contrast, naturally occurring quercetin compounds are primarily glycosides, with only very small quantity occurring as an aglycone. Once absorbed from the gut, most quercetin compounds are metabolized to quercetin glucuronides, the primary metabolic form detected in plasma. As mentioned, quercetin does not principally occur in the form in which it is available as a dietary supplement (an aglycone). Instead, it occurs mostly as quercetin glycosides. Isoquercetin is one ...
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7 Best Organic Vitamin D3 and K2 Supplements 2025

By Dr Frank Yap, MD
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In recent weeks and months, several publications and studies have suggested that maintaining adequate levels of vitamin D would seem potentially beneficial in fighting the COVID-19 infection. How do you know that your vitamin D level is adequate? Most people in the United States consume less than recommended amounts of vitamin D. An analysis of data from the 2015–2016 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 5.1 mcg (204 IU) in men, 4.2 mcg (168 IU) in women, and 4.9 mcg (196 IU) in children aged 2–19 years ( NHANES ). What Is Vitamin D? Vitamin D is a fat-soluble vitamin, meaning that it dissolves in fats and oils and can be stored in your body for a long time. Vitamin D is important to the body in many ways. It helps the body absorb calcium from food and supplements. Muscles need it to move, for example, nerves need it to carry messages between the brain and every body part, and the immune syste...
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Natto vs Nattokinase vs Nattozimes: What's the Difference?

By Dr Frank Yap, MD
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Marketing geniuses have positioned soy as the wonder health alternative to virtually everything. In most supermarkets, you’ll find soy milk, soy protein, soybean oil, soy lecithin and even soy soap. Unfortunately, though, many forms of soy are not necessarily as healthy as food manufacturers would like you to believe. The problem is the soy you see in all these foods is not the traditionally grown crop of Japan. In fact, the majority of soy that you find in in grocery stores is actually genetically modified (GMO), produced in a different way and doesn’t yield the same nutritional benefits. However, when you ferment soybeans you have a completely different product that boasts an entirely separate set of nutrients, which is why when it comes to soy, the safest and best way to consume it is through fermented foods like miso, tempeh or natto. So what is natto, and how can it impact your health? Let’s dig in. What is Natto? Natto is a popular food in Japan, and is made by fermenting soybean...
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9 Best Vitamin D3, K2 and Magnesium Supplements 2025

By Dr Frank Yap, MD
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Magnesium, vitamin D and Vitamin K2 are vitamin and minerals that are vital to several bodily processes. Though they occur naturally in a variety of foods, many people take supplements to help increase their intake. Magnesium, Vitamin D3 and Vitamin K Dosage The typical daily dosage recommendations for these nutrients are: Magnesium: 400–500 mg Vitamin D3: 800 IU (20 mcg)  Vitamin K : 120mcg Food With Magnesium, Vitamin D3 and Vitamin K Magnesium: dark chocolate, avocados, nuts, leafy vegetables, and legumes Vitamin D3: avocados, nuts, seeds, full-fat dairy products and eggs Vitamin K: turnips, spinach, kale, brocolli, soybeans, carrots, Chicken If you’re concerned you may be deficient in any of these nutrients, talk to a health professional who can test your levels and determine whether you should eat more of these foods or take a supplement. Benefits and uses 1. May support bone health Magnesium  plays a key role in converting vitamin D into its active form, which aids calci...
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9 Best Calcium, Magnesium, Vitamin D3 and K2 Supplements 2025

By Dr Frank Yap, MD
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Calcium, magnesium, vitamin D and Vitamin K2 are vitamin and minerals that are vital to several bodily processes. Though they occur naturally in a variety of foods, many people take supplements to help increase their intake. Benefits and uses 1. May support bone health Calcium is the main mineral in your bones, which hold more than 99% of your body’s calcium stores. Your body is constantly regenerating its bone tissue, so it’s important to consume an adequate amount of this mineral daily ( bones.nih.gov ). Magnesium plays a key role in converting vitamin D into its active form, which aids calcium absorption ( Trusted Source ). Therefore, you can minimize your vitamin D requirement by making sure you’re also getting enough magnesium. Research has confirmed higher magnesium intake helps reduce your risk of vitamin D deficiency by activating more of it.  A  groundbreaking 2017 review  compiled over 80 studies that show vitamin D3 and K2 together might be greater than...
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12 Best Natural Ozempic Alternatives 2025 (Resource Guide)

By Dr Frank Yap, MD
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Some of the best natural alternatives to Ozempic include berberine, a supplement that has shown potential in managing blood sugar and promoting weight loss, often referred to as “nature’s Ozempic” in wellness communities. High-fiber foods also play a crucial role by helping to control appetite and improve metabolic health. Other natural options include psyllium husk, which provides soluble fiber supporting satiety and digestive health, and curcumin, known for its anti-inflammatory properties, which may aid metabolic balance. Additionally, green tea extract, magnesium, protein-rich foods, and lifestyle factors like adequate sleep and stress reduction contribute to weight management.  However, none of these natural alternatives are as potent or fast-acting as Ozempic itself, and their effects can vary widely among individuals. It is important to consult a healthcare provider before starting any supplement regimen, especially for managing blood sugar or weight loss. The 2023 rep...
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