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Ivermectin and Fenbendazole in the Treatment of Psoriasis? A Case Series of 13 Patients (2026)

By Dr Frank Yap, MD
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Abstract Psoriasis is a chronic autoimmune condition affecting approximately 7.5 million individuals in the United States, with significant economic, physical, and psychological burdens. This case series reports on 13 patients who experienced notable improvements in psoriasis symptoms following treatment with ivermectin and/or fenbendazole, antiparasitic agents repurposed for this indication. Cases were derived from self-reported testimonials shared on social media platforms. Treatment durations ranged from 3 days to 3 months, with dosages varying between 6 mg ivermectin twice daily and combinations with fenbendazole. Rapid resolution of skin lesions was observed in most cases, with some achieving near-complete clearance. While these anecdotal reports suggest potential therapeutic efficacy, controlled clinical trials are warranted to validate these findings and elucidate underlying mechanisms. Introduction Psoriasis is a chronic inflammatory disorder characterized by hyperproliferation...
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7 Best Cetylpyridinium Chloride Mouthwash Brands 2025

By Dr Frank Yap, MD
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A meta-analysis of 3 studies (C19early 2025) concluded that CPC (CetylPyridinium Chloride) may significantly lower risk with  viral clearance . One study shows significant benefit. Meta analysis using the most serious outcome reported shows 83% [6‑97%] lower risk . Results are consistent with early treatment being more effective than late treatment. A study, published in Nature ( Takeda 2022 ) concluded that CPC (CetylPyridinium Chloride) may inhibit SARS-CoV-2 infection even at lower concentrations. Another team of international scientists has also demonstrated the usefulness of cetylpyridinium chloride-containing mouthwashes in inhibiting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and reducing the risk of viral transmission. The study is published in the Journal of Medical Microbiology (2022). A scientific review, published in the  Journal of Formosan Medical Association  (2022) also concluded that mouthwash containing CPC shows potential fo...
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Best Vitamin D3 + K2 Supplements in 2026: Doctor-Reviewed Picks for Bone, Heart & Immune Health

By Dr Frank Yap, MD
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Vitamin D3 and Vitamin K2 are two of the most commonly deficient—and misunderstood—nutrients today. While Vitamin D improves calcium absorption, Vitamin K2 determines where that calcium actually goes . That’s why taking Vitamin D without K2 may be incomplete—and in some cases counterproductive. After reviewing ingredient quality, dosing accuracy, brand transparency, and real-world user feedback, the following are the best Vitamin D3 + K2 supplements available in 2026 . Most people in the United States consume less than recommended amounts of vitamin D . An analysis of data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 4.3 mcg in men, 3.8 mcg in women, and 5 mcg (200 IU) in children aged 2–19 years ( NHANES 2017 - 2018 ). Why Trust This Guide? This review prioritizes supplements that meet four non-negotiable criteria : Uses Vitamin D3 (cholecalciferol) — not D2 Includes Vitam...
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Quercetin and Bromelain for Allergies 2023

By Dr Frank Yap, MD
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More than 50 million Americans who live with seasonal allergies. These symptoms tend to crop up with the onset of tree allergy season, followed by grass and weed season, notes Kevin McGrath, MD, an allergist in private practice in Wethersfield, Connecticut, and spokesperson for the American College of Allergy, Asthma, and Immunology. "The combination of trees, grasses, weeds, and molds makes for a difficult spring for most allergy patients and leads to sneezing, congestion, postnasal drip, sinus pain and pressure, watery eyes, and fatigue," he says. The good news is that there are a myriad of over the counter treatments out there that help ease the debilitating symptoms that accompany seasonal allergies.   Related: Best Nasal Sprays for Allergies What is Quercetin and Bromelain? Studies have shown bromelain combined with quercetin, produce greater anti-inflammatory benefits than either one used alone. Thus, the combination of bromelain and quer...
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9 Best Vitamin D3, K2 and Magnesium Supplements 2025

By Dr Frank Yap, MD
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Magnesium, vitamin D and Vitamin K2 are vitamin and minerals that are vital to several bodily processes. Though they occur naturally in a variety of foods, many people take supplements to help increase their intake. Magnesium, Vitamin D3 and Vitamin K Dosage The typical daily dosage recommendations for these nutrients are: Magnesium: 400–500 mg Vitamin D3: 800 IU (20 mcg)  Vitamin K : 120mcg Food With Magnesium, Vitamin D3 and Vitamin K Magnesium: dark chocolate, avocados, nuts, leafy vegetables, and legumes Vitamin D3: avocados, nuts, seeds, full-fat dairy products and eggs Vitamin K: turnips, spinach, kale, brocolli, soybeans, carrots, Chicken If you’re concerned you may be deficient in any of these nutrients, talk to a health professional who can test your levels and determine whether you should eat more of these foods or take a supplement. Benefits and uses 1. May support bone health Magnesium  plays a key role in converting vitamin D into its active form, which aids calci...
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Retatrutide vs Tirzepatide vs Semaglutide (Ozempic): GLP-1 Wars — Updated Review (2026)

By Dr Frank Yap, MD
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The landscape of obesity treatment has evolved dramatically with the introduction of advanced medical therapeutics like retatrutide (RETA, LY3437943), tirzepatide (Mounjaro), and semaglutide (Ozempic) . Glucagon-like peptide-1 receptor agonists and co-agonists, originally developed to manage type 2 diabetes, have shown remarkable efficacy in promoting weight loss, making them game-changers for obesity management. However, each drug has unique mechanisms, benefits, and potential applications, including emerging roles in cancer prevention. This article compares their mechanisms, clinical efficacy, broader health benefits, safety profiles, regulatory status, and practical considerations to help patients, clinicians, and informed readers understand how they stack up in 2026. Update: Are GLP-1s the first longevity drugs ? (Nature 2025) Credit: GoodRx Health Mechanism of Action Semaglutide : Semaglutide (Ozempic and Wegovy) is a glucagon-like peptide-1 receptor agonist (GLP-1 RA). It mimics...
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9 Best Calcium, Magnesium, Vitamin D3 and K2 Supplements 2025

By Dr Frank Yap, MD
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Calcium, magnesium, vitamin D and Vitamin K2 are vitamin and minerals that are vital to several bodily processes. Though they occur naturally in a variety of foods, many people take supplements to help increase their intake. Benefits and uses 1. May support bone health Calcium is the main mineral in your bones, which hold more than 99% of your body’s calcium stores. Your body is constantly regenerating its bone tissue, so it’s important to consume an adequate amount of this mineral daily ( bones.nih.gov ). Magnesium plays a key role in converting vitamin D into its active form, which aids calcium absorption ( Trusted Source ). Therefore, you can minimize your vitamin D requirement by making sure you’re also getting enough magnesium. Research has confirmed higher magnesium intake helps reduce your risk of vitamin D deficiency by activating more of it.  A  groundbreaking 2017 review  compiled over 80 studies that show vitamin D3 and K2 together might be greater than...
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17 Best Natural Ozempic Alternatives 2026 (Resource Guide)

By Dr Frank Yap, MD
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Some of the best natural alternatives to Ozempic include berberine, a supplement that has shown potential in managing blood sugar and promoting weight loss, often referred to as “nature’s Ozempic” in wellness communities. High-fiber foods also play a crucial role by helping to control appetite and improve metabolic health. Other natural options include psyllium husk, which provides soluble fiber supporting satiety and digestive health, and curcumin, known for its anti-inflammatory properties, which may aid metabolic balance. Additionally, green tea extract, magnesium, protein-rich foods, and lifestyle factors like adequate sleep and stress reduction contribute to weight management.  Update (March 2026): An open letter from Eli Lilly and Company warning of potential patient safety risks associated with tirzepatide compounded with vitamin B12 However, none of these natural alternatives are as potent or fast-acting as Ozempic itself, and their effects can vary widely among individual...
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9 Best Anti Aging Skincare Hong Kong 2025

By Dr Frank Yap, MD
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It’s natural to have complex feelings about noticing signs of aging. You can embrace the beauty and privilege that it is to age, while also not love all of the physical changes that come along with it.  If you’d like to soften these signs but don’t want to go the injectables route, there are non-invasive products that can help. In the world of beauty products, there's perhaps no category more saturated than the anti-aging market. What to Look for in an Anti-Aging Product a. Vitamin C An antioxidant powerhouse, vitamin C is directly involved with collagen production in the body. Vitamin C is beneficial in anti-aging products for several reasons: It protects skin from environmental stressors, promotes cell turnover, and can fade dark spots which contribute to the appearance of aging skin. Products containing vitamin C can irritate sensitive skin, so be sure to start out using a low concentration if your skin is reactive. b. Retinoids Retinoids are a category of ingredients, and retin...
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7 Best Organic Vitamin D3 and K2 Supplements 2025

By Dr Frank Yap, MD
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In recent weeks and months, several publications and studies have suggested that maintaining adequate levels of vitamin D would seem potentially beneficial in fighting the COVID-19 infection. How do you know that your vitamin D level is adequate? Most people in the United States consume less than recommended amounts of vitamin D. An analysis of data from the 2015–2016 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 5.1 mcg (204 IU) in men, 4.2 mcg (168 IU) in women, and 4.9 mcg (196 IU) in children aged 2–19 years ( NHANES ). What Is Vitamin D? Vitamin D is a fat-soluble vitamin, meaning that it dissolves in fats and oils and can be stored in your body for a long time. Vitamin D is important to the body in many ways. It helps the body absorb calcium from food and supplements. Muscles need it to move, for example, nerves need it to carry messages between the brain and every body part, and the immune syste...
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