Stem Cell Therapy Research Review 2020 by Category
There are more than 250,000 scientific publications published on "stem cell' on the National Library of Medicine (PubMed). As of December 2020, more than 8,000 studies have been launched to investigate the potential of stem cell therapy under the U.S. Clinical Trial Registry. Just for 2020 alone, there are more than 20,000 scientific publications published on "stem cell' on the National Library of Medicine (PubMed). There's a lot to read and catch up to. How do we keep up with all these stem cell therapy evidence?
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| Stem Cell Research Summary |
Stem cell therapy has recently gained popularity as a promising treatment option for conditions where the current medical treatment protocols have been exhausted. However, there is also a lot of confusion due to the overwhelming mixing of credible scientific information and marketing hypes available on the internet.
We do get the following questions very frequently: Does it really work? Is it safe? Is it a scam? Is there any scientific evidence? How do you get the stem cells?
If you are new to stem cells, check out stem cell basics.
Due to the fast-changing pace of research and technology, new evidence accumulates rapidly and clinical guidelines need to be periodically updated.
We have compiled and summarised essential information below in layman's terms so that you can understand and make a better informed decision.
This article contains information and links to list of stem cell therapy and research in various categories. This list is a work-in-progress list as new evidence might be added from time to time.
STEM CELL THERAPY EVIDENCE AND RESEARCH BY CATEGORY
Here, we have listed and compiled all significant scientific publications related to stem cell therapy for the year 2020. The list was complied by running various searches on PubMed. Each study is hyperlinked to the abstract in the U.S. National Library of Medicine or the full text article to make it easier for healthcare providers or scientists to access more details. The list was complied by running various searches on PubMed.
In order to make it consumer friendly, we have tried to summarise the studies and minimise the technical jargons.
Here is the list by category.
In order to make it consumer friendly, we have tried to summarise the studies and minimise the technical jargons.
Here is the list by category.
1. Stem Cell and Leukemia
Leukemia is the most established indication for stem cell therapy and therefore has the most evidence to-date. There are more than 28,000 publications related to the use of stem cells and leukemia.
As of December 2020, there are more than 1,000 studies that have been launched to investigate the benefits of stem cell therapy and leukemia. You can review the status and details of these trials on clinicaltrials.gov.
Can stem cell therapy be used for the treatment of COVID-19?
Just for 2020 alone, there are already more than 700 publications published on "stem cell and covid19" on the National Library of Medicine (PubMed).
As of December 2020, there are 55 studies that have been launched to investigate the benefits of stem cell therapy and COVID-19. You can review the status and details of these trials on ClinicalTrials.
Mesenchymal stem cells are used as immuno-modulators for severe COVID-19 patients and some of the trial projects are launched in combination with other medications such as interleukin (IL) 6 inhibitors e.g. tocilizumab. IL-6 inhibitors have been studied mainly for their potential to calm down the 'cytokine storm' associated with ARDS (acute respiratory distress syndrome), a severe COVID-19 lung complication.
For a more comprehensive review, check out Can Stem Cell Therapy Help Against the Latest Coronavirus?
3. Stem Cell Therapy for Knee Pain (knee osteoarthritis)
Some doctors and media channels argue that there is very little evidence to support the use of stem cells to treat orthopaedic conditions. However, there are more than 250 publications related to the use of stem cells in treating knee orthopaedic conditions alone.
Just for 2020 alone, there are 96 publications published on "stem cell and knee osteoarthritis" on the National Library of Medicine (PubMed). We have not even included publications on other joints.
There are currently 80 studies on stem cell treatment for knee osteoarthritis under the U.S. Clinical Trial Registry.
Regenexx, the largest provider of stem cell therapy for orthopaedic conditions in the United States alone, have treated 30,000 patients with stem cell therapy for various joint conditions including knee pain.
www.onedaymd.com
Several other comparative studies have demonstrated good evidence in the treatment of osteoarthritis. However, there are several approaches and cell lines used. More well-designed and randomised controlled trials are needed to evaluate the best approach and universal consensus. As studies continue, the methods, forms and combinations of stem cell preparations are improving, and outcomes are expected to improve as well.
Just for 2020 alone, there are 96 publications published on "stem cell and knee osteoarthritis" on the National Library of Medicine (PubMed). We have not even included publications on other joints.
There are currently 80 studies on stem cell treatment for knee osteoarthritis under the U.S. Clinical Trial Registry.
Regenexx, the largest provider of stem cell therapy for orthopaedic conditions in the United States alone, have treated 30,000 patients with stem cell therapy for various joint conditions including knee pain.
www.onedaymd.com
Several other comparative studies have demonstrated good evidence in the treatment of osteoarthritis. However, there are several approaches and cell lines used. More well-designed and randomised controlled trials are needed to evaluate the best approach and universal consensus. As studies continue, the methods, forms and combinations of stem cell preparations are improving, and outcomes are expected to improve as well.
Just for 2020 alone, there are 151 publications published on "stem cell and diabetes mellitus" on the National Library of Medicine (PubMed).
As of Aug 2020, there are more than 120 studies that have been launched to investigate the benefits of stem cell therapy and diabetes mellitus. You can review the status and details of these trials on clinicaltrials.gov.
Related: Stem cell therapy for Diabetes in Malaysia
5. Stem Cell Therapy for Stroke
There are more than 3,000 publications related to the use of stem cells and stroke.
Stroke constitutes the second leading cause of death worldwide. Stem cell therapy that has been developed over the past several decades represents a promising alternative or supplemental strategy; notably, this approach has already reached the translational stage, with therapeutic results in humans having been discussed in various publications.
In this review (published in Nature), the authors examined the clinical research trends related to stem cell therapy products in the stroke space based on information obtained from the ClinicalTrials.gov website and International Clinical Trials Research Platform (ICTRP) portal site.
Just for 2020 alone, there are more than 200 publications published on "stem cell and stroke" on the National Library of Medicine (PubMed).
As of Aug 2020, there are more than 60 studies that have been launched to investigate the benefits of stem cell therapy and diabetes mellitus. You can review the status and details of these trials on clinicaltrials.gov.
6. Stem Cell Therapy for Spinal Cord Injury
There are more than 1,800 scientific publications published related to "stem cell" and "spinal cord injury" on the National Library of Medicine.
Just for 2020 alone, there are more than 140 publications published on "stem cell and spinal cord injury" on the National Library of Medicine (PubMed).
As of August 2020, more than 50 studies have been launched to investigate the potential of stem cell therapy for spinal cord injuries under the U.S. Clinical Trial Registry.
7. Stem Cell Therapy for Autism
There are more than 400 publications related to the use of stem cells and autism.
This year alone (2020), there are more than 80 publications published on "stem cell and autism" on the National Library of Medicine (PubMed). Clinical trials have been performed to demonstrate safety and efficacy of stem cells autism management.
As of August 2020, 12 studies have been launched to investigate the potential of stem cell therapy for autism under the U.S. Clinical Trial Registry. You can search the database to look for more details of the clinical trials including the countries and centres that are conducting them.
8. Stem Cell Therapy for Anti-Aging Research UpdateJust for 2020 alone, there are more than 200 publications published on "stem cell and stroke" on the National Library of Medicine (PubMed).
As of Aug 2020, there are more than 60 studies that have been launched to investigate the benefits of stem cell therapy and diabetes mellitus. You can review the status and details of these trials on clinicaltrials.gov.
6. Stem Cell Therapy for Spinal Cord Injury
There are more than 1,800 scientific publications published related to "stem cell" and "spinal cord injury" on the National Library of Medicine.
Just for 2020 alone, there are more than 140 publications published on "stem cell and spinal cord injury" on the National Library of Medicine (PubMed).
As of August 2020, more than 50 studies have been launched to investigate the potential of stem cell therapy for spinal cord injuries under the U.S. Clinical Trial Registry.
7. Stem Cell Therapy for Autism
There are more than 400 publications related to the use of stem cells and autism.
This year alone (2020), there are more than 80 publications published on "stem cell and autism" on the National Library of Medicine (PubMed). Clinical trials have been performed to demonstrate safety and efficacy of stem cells autism management.
As of August 2020, 12 studies have been launched to investigate the potential of stem cell therapy for autism under the U.S. Clinical Trial Registry. You can search the database to look for more details of the clinical trials including the countries and centres that are conducting them.
There are more than 150 publications related to the use of stem cells and anti-aging.
Just for 2020 alone, there are 33 publications published on "stem cell and anti aging" on the National Library of Medicine (PubMed).
As of August 2020, 2 studies were found for 'stem cell and anti-aging' under the U.S. Clinical Trial Registry.
www.AestheticsAdvisor.com
Despite the fact that there are many published studies on stem cell therapy for anti-aging, major media has been slow to report the findings.
9. Stem Cell Therapy for Kidney Diseases
There are more than 650 published studies related to the use of stem cells and kidney disease and more than 300 published studies related to stem cells and kidney failure.
The increasing incidence of kidney diseases raises considerable concerns regarding human health worldwide. A number of studies in recent years have attempted to identify the underlying mechanisms of renal repair in order to explore the potential regenerative capacity of the kidneys. Many papers have reported on the potential use of stem cells of different origins for treating many different pathologies, including kidney diseases.
Several clinical trials have confirmed the safety and tolerability of stem cells, and in particular of MSC-based therapies (Mesenchymal Stem Cell), in patients with renal diseases and kidney transplants (Int J of Mol Sci. 2019).
This year alone (2020), there are more than 80 publications published on "stem cell and kidney disease" on the National Library of Medicine (PubMed). Clinical trials have been performed to demonstrate safety and efficacy of stem cells autism management.
As of August 2020, more than 100 studies have been launched to investigate the potential of stem cell therapy for kidney disease under the U.S. Clinical Trial Registry. You can search the database to look for more details of the clinical trials including the countries and centres that are conducting them.
Related: Stem Cell Treatment for Kidney Diseases in Malaysia
10. Stem Cell Therapy for Liver Diseases
There are more than 900 published studies related to the use of stem cells and liver disease and more than 600 published studies related to stem cells and liver failure.
Liver failure caused by liver cirrhosis, due to various long term liver diseases such as chronic hepatitis B and non-alcoholic fatty liver disease; was thought to be irreversible. A liver transplant is currently the standard treatment to end-stage liver cirrhosis.
However, not every liver failure and liver cirrhosis patients are eligible for a liver transplant in Malaysia. The shortage of matching donors and the high risk of surgical-associated complications further limits the success of a liver transplant.
Since stem cells can be transformed into liver-like cells, the potential of stem cell therapy to treat liver failure and liver cirrhosis has been studied as an interesting new feasible option.
Just for 2020 alone, there are more than 80 publications published on "stem cell and liver disease" on the National Library of Medicine (PubMed).
As of August 2020, more than 90 studies were found for 'stem cell and liver disease' under the U.S. Clinical Trial Registry.
11. Stem Cell Therapy for Back Pain
There are more than 200 published studies related to the use of stem cells and back pain.
Do take note that back pain problems may arise from several causes and degenerative disc disease is just one of the many causes of back pain. Therefore, the importance of finding out the cause first (diagnosis) before treatment.
This year alone (2020), there are 20 publications published on "stem cell and back pain" on the National Library of Medicine (PubMed). Clinical trials have been performed to demonstrate safety and efficacy of stem cell back pain management.
Most patients in these studies had significant pain relief. Some patients also revealed reversal of disc degeneration. No patients had any serious complications. Since stem cells are a new development in medicine, there is not an abundance of data. However, the data that exists shows that stem cell injections into the disc results in pain relief and improvement in function.
As of August 2020, 10 studies have been launched to investigate the potential of 'stem cell therapy for back pain' under the U.S. Clinical Trial Registry. You can search the database to look for more details of the clinical trials including the countries and centres that are conducting them.
There is a product currently in phase 3 clinical trials at the US Food and Drug Administration (FDA) called Mesoblast. If the results from that study are favourable, then we could have stem cells available for the treatment of degenerative disc disease very soon.
Conclusion: Although some preliminary information has been obtained, much remains to be determined with respect to the best method of stem cell delivery, source of stem cell, numbers of cells to be delivered and the patient selection to receive such therapy. These considerations are common to all potential spine-related stem cell applications.
12. Stem Cell Hair Treatment
There are more than 150 publications related to the use of stem cells and hair loss.
Just for 2020 alone, there are 23 publications published on "stem cell and hair loss" on the National Library of Medicine (PubMed).
As of December 2020, 9 studies were found for 'stem cell and hair loss' under the U.S. Clinical Trial Registry.
Other Indications
The public may search a database of NIH-sponsored clinical trials at clinicaltrials.gov. Enter the search terms of interest (e.g., Parkinson's Disease and stem cells) to search for applicable clinical trials.
There are more than 650 published studies related to the use of stem cells and kidney disease and more than 300 published studies related to stem cells and kidney failure.
The increasing incidence of kidney diseases raises considerable concerns regarding human health worldwide. A number of studies in recent years have attempted to identify the underlying mechanisms of renal repair in order to explore the potential regenerative capacity of the kidneys. Many papers have reported on the potential use of stem cells of different origins for treating many different pathologies, including kidney diseases.
Several clinical trials have confirmed the safety and tolerability of stem cells, and in particular of MSC-based therapies (Mesenchymal Stem Cell), in patients with renal diseases and kidney transplants (Int J of Mol Sci. 2019).
This year alone (2020), there are more than 80 publications published on "stem cell and kidney disease" on the National Library of Medicine (PubMed). Clinical trials have been performed to demonstrate safety and efficacy of stem cells autism management.
As of August 2020, more than 100 studies have been launched to investigate the potential of stem cell therapy for kidney disease under the U.S. Clinical Trial Registry. You can search the database to look for more details of the clinical trials including the countries and centres that are conducting them.
Related: Stem Cell Treatment for Kidney Diseases in Malaysia
10. Stem Cell Therapy for Liver Diseases
There are more than 900 published studies related to the use of stem cells and liver disease and more than 600 published studies related to stem cells and liver failure.
Liver failure caused by liver cirrhosis, due to various long term liver diseases such as chronic hepatitis B and non-alcoholic fatty liver disease; was thought to be irreversible. A liver transplant is currently the standard treatment to end-stage liver cirrhosis.
However, not every liver failure and liver cirrhosis patients are eligible for a liver transplant in Malaysia. The shortage of matching donors and the high risk of surgical-associated complications further limits the success of a liver transplant.
Just for 2020 alone, there are more than 80 publications published on "stem cell and liver disease" on the National Library of Medicine (PubMed).
As of August 2020, more than 90 studies were found for 'stem cell and liver disease' under the U.S. Clinical Trial Registry.
11. Stem Cell Therapy for Back Pain
There are more than 200 published studies related to the use of stem cells and back pain.
Do take note that back pain problems may arise from several causes and degenerative disc disease is just one of the many causes of back pain. Therefore, the importance of finding out the cause first (diagnosis) before treatment.
This year alone (2020), there are 20 publications published on "stem cell and back pain" on the National Library of Medicine (PubMed). Clinical trials have been performed to demonstrate safety and efficacy of stem cell back pain management.
Most patients in these studies had significant pain relief. Some patients also revealed reversal of disc degeneration. No patients had any serious complications. Since stem cells are a new development in medicine, there is not an abundance of data. However, the data that exists shows that stem cell injections into the disc results in pain relief and improvement in function.
As of August 2020, 10 studies have been launched to investigate the potential of 'stem cell therapy for back pain' under the U.S. Clinical Trial Registry. You can search the database to look for more details of the clinical trials including the countries and centres that are conducting them.
There is a product currently in phase 3 clinical trials at the US Food and Drug Administration (FDA) called Mesoblast. If the results from that study are favourable, then we could have stem cells available for the treatment of degenerative disc disease very soon.
Conclusion: Although some preliminary information has been obtained, much remains to be determined with respect to the best method of stem cell delivery, source of stem cell, numbers of cells to be delivered and the patient selection to receive such therapy. These considerations are common to all potential spine-related stem cell applications.
12. Stem Cell Hair Treatment
There are more than 150 publications related to the use of stem cells and hair loss.
Just for 2020 alone, there are 23 publications published on "stem cell and hair loss" on the National Library of Medicine (PubMed).
As of December 2020, 9 studies were found for 'stem cell and hair loss' under the U.S. Clinical Trial Registry.
The public may search a database of NIH-sponsored clinical trials at clinicaltrials.gov. Enter the search terms of interest (e.g., Parkinson's Disease and stem cells) to search for applicable clinical trials.
Conclusion
If there are any new major stem cell related evidence that we’ve missed, please let us know in the comments and we’ll add them to the post!
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