Benefits of NMN and Resveratrol 2023
In this article, we will look at the potential benefits of taking resveratrol and NMN supplements, their definitions, chemical structure, as well as sources of these compounds.
Understanding NMN and Resveratrol
Benefits of NMN
The older we get, the less NAD+ is present in our cells. Various studies show that NMN has beneficial effects on aging diseases and symptoms (R,R,R,R).
For example, long term administration of NMN mitigated age-associated decline in mice: NMN reduced the typical age-associated increase in body weight, improved energy metabolism, improved lipids in the blood and insulin sensitivity and ameliorated eye function (R).
NMN can also improve aging-related decline in fertility (R), improve bone health (R) and vascular health (R,R,R).
Benefits of Resveratrol
In a study where healthy individuals were given a 6-week course of 40mg of resveratrol derived from the extract of a plant called Japanese knotweed, multiple anti-inflammatory effects were observed. Reductions in pro-inflammatory markers such as the expression of pro-inflammatory cytokines TNF-Alpha and IL-6, as well as the concentrations of reactive oxygen species were noted after the trial.
IL-6 and TNF-Alpha are significant hindrances in longevity, with TNF-Alpha being correlated with every disease known to man.
The most significant way in which resveratrol acts to improve longevity is through sirtuin activation. World at Large reported on Monday: “Sirtuins use NAD+ to control the genes involved in some of the most critical systems in our biology including energy metabolism, circadian rhythms, autophagy, DNA repair, and cell survival…”.
Sirtuins also play a role in insulin release, lipid mobilization, stress responses, and lifespan modulation, and expression of sirtuins has been shown to mimic many of the beneficial effects observed in calorie-restriction, another longevity-based field of research.
Caloric restriction has been widely-shown to increase healthspan and lifespan in organisms from bacteria to primates.
A study in Nature reports just that, explaining their finding that in yeast, “resveratrol mimics calorie restriction by stimulating sirtuin-2, increasing DNA stability and extending lifespan by 70%.”
Taking resveratrol in supplement form must be done with a little more application than other supplements.
Dr. Rhonda Patrick, longevity expert, has collected much of the resveratrol research on her website, including how the bioavailability of resveratrol was shown to be higher with a moderate fat breakfast than with a high fat breakfast and how resveratrol is safe in humans in doses as high as 5 grams.
In a conversation Dr. Rhonda Patrick had with Harvard Professor of Genetics Dr. David Sinclair, the latter recommends the storing of resveratrol in a cold dark environment at all times.
Important safety note: Resveratrol is not suitable for people undergoing blood-thinning medication.
Resveratrol vs Trans-ResveratrolResveratrol and trans-resveratrol are sometimes confused because they are similar in structure.
Resveratrol is just the umbrella term of 2 types of geometric isoforms:
Consumers should be aware that they may not be getting what they think they are when they purchase products that contain cis-resveratrol.
If the resveratrol is cheap, or they do not specifically say trans-resveratrol. You may want to reconsider in order to get the effects you want.
In order to maximize the chance of absorption of any dietary supplement or tablet, it should be micronized.
Micronization is the process of making the ingredient into smaller micro particles to enhance the absorption of fat soluble ingredients.
Micronized trans-resveratrol has a much higher chance of being absorbed than non-micronized resveratrol. Super micronized resveratrol is even more effective as it is easier to absorb. It is important to make sure that you are taking a micronized or super micronized form of resveratrol in order to maximise the benefits.
Resveratrol is fat soluble, meaning it will not absorb in water, and it requires a source of fat to be absorbed.
Benefit of NMN with Resveratrol Combination
Chemical Structures of NMN and ResveratrolThe chemical structure of resveratrol includes an aromatic ring connected to two hydroxyl groups (-OH), while the structure of NMN includes an amide group (-NH2). Both molecules are relatively small in size but contain powerful antioxidant properties.
Best NMN and Resveratol Supplement 2023
- Prohealth Longevity NMN Pro Complete (NMN, Trans-Resveratrol and TMG)
- NMN Pro Complete is the first and only perfectly balanced combination of NMN, Trans-Resveratrol and TMG on the market. Instead of having to take three separate supplements each day, you can now get the ideal balance of all three in one convenient serving. A single scoop of NMN Pro Complete will provide you with 1,000 mg of NMN, 1,000 mg of trans-resveratrol, and 500 mg of TMG – the daily dosage most often recommended by the world's leading longevity experts.
- Suggested use: Take 1 scoop daily under the tongue or dissolved in water, preferably in the morning or as directed by your health care practitioner.
Painstaking attention to quality and purity has led to findings that ProHealth NMN remains intact and stable for up to two years. Pro 300 gets rave reviews, often beating popular products like Genex. Pay attention to price, however, as I’ve seen it fluctuate by nearly $50. I’ve also noticed that there isn’t a GMP-certified logo on the bottle itself. If you want a shelf-stable NMN that lasts, ProHealth Pro 300 is a top choice." - outliyr.com