Benefits of NMN and Resveratrol 2023

As we age, our bodies naturally start to break down, and we become more susceptible to age-related diseases. However, recent research has shown that certain supplements, such as NMN and resveratrol, can help slow down the aging process and promote overall health and well-being. its.

In this article, we will look at the potential benefits of taking resveratrol and NMN supplements, their definitions, chemical structure, as well as sources of these compounds.

Understanding NMN and Resveratrol 

NMN (Nicotinamide Mononucleotide) and Resveratrol are two natural compounds that have been shown to have powerful anti-aging properties. 

NMN, or nicotinamide mononucleotide, is a precursor molecule for the production of NAD+ in cells. Studies suggest that it can help slow down the ageing process by increasing cellular energy levels.

Resveratrol is a natural compound found in grapes, red wine, and certain berries, which has been shown to have antioxidant and anti-inflammatory properties.

Benefits of NMN 

Nicotinamide mononucleotide (NMN) is a one of the precursors of NAD+. In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. In animals, NMN slows down various aging processes.

The older we get, the less NAD+ is present in our cells. Various studies show that NMN has beneficial effects on aging diseases and symptoms (R,R,R,R).

For example, long term administration of NMN mitigated age-associated decline in mice: NMN reduced the typical age-associated increase in body weight, improved energy metabolism, improved lipids in the blood and insulin sensitivity and ameliorated eye function (R).

NMN can also improve aging-related decline in fertility (R), improve bone health (R) and vascular health (R,R,R).

Benefits of Resveratrol 

Short of your bartender explaining to you why this or that particular bottle of red wine is good for your heart, resveratrol is only recently beginning to be explored as a potential longevity compound. It exists in the seeds, fruits, skins, leaves, stems, and other parts of a variety of plants, and is expressed therein during periods of stress on the plant.

This is why red wine is noted as having heart-healthy or antioxidant effects on the body. During the winemaking process, the stressed parts of the grape confer resveratrol into the beverage, however it’s likely negligible amounts.

In a study where healthy individuals were given a 6-week course of 40mg of resveratrol derived from the extract of a plant called Japanese knotweed, multiple anti-inflammatory effects were observed. Reductions in pro-inflammatory markers such as the expression of pro-inflammatory cytokines TNF-Alpha and IL-6, as well as the concentrations of reactive oxygen species were noted after the trial.

IL-6 and TNF-Alpha are significant hindrances in longevity, with TNF-Alpha being correlated with every disease known to man.

The most significant way in which resveratrol acts to improve longevity is through sirtuin activation. World at Large reported on Monday: “Sirtuins use NAD+ to control the genes involved in some of the most critical systems in our biology including energy metabolism, circadian rhythms, autophagy, DNA repair, and cell survival…”.

Sirtuins also play a role in insulin release, lipid mobilization, stress responses, and lifespan modulation, and expression of sirtuins has been shown to mimic many of the beneficial effects observed in calorie-restriction, another longevity-based field of research.

Caloric restriction has been widely-shown to increase healthspan and lifespan in organisms from bacteria to primates.

A study in Nature reports just that, explaining their finding that in yeast, “resveratrol mimics calorie restriction by stimulating sirtuin-2, increasing DNA stability and extending lifespan by 70%.”

Taking resveratrol in supplement form must be done with a little more application than other supplements.

Dr. Rhonda Patrick, longevity expert, has collected much of the resveratrol research on her website, including how the bioavailability of resveratrol was shown to be higher with a moderate fat breakfast than with a high fat breakfast and how resveratrol is safe in humans in doses as high as 5 grams.

In a conversation Dr. Rhonda Patrick had with Harvard Professor of Genetics Dr. David Sinclair, the latter recommends the storing of resveratrol in a cold dark environment at all times.

Important safety note: Resveratrol is not suitable for people undergoing blood-thinning medication.

Resveratrol vs Trans-Resveratrol

Resveratrol and trans-resveratrol are sometimes confused because they are similar in structure.

Resveratrol is just the umbrella term of 2 types of geometric isoforms:
  • cis-resveratrol, 
  • trans-resveratrol.
Many companies use cis-resveratrol because it is cheap to make and they hope that consumers will not know the difference. Cis-resveratrol is the form of resveratrol that does not have any health benefits. These companies are hoping to capitalise on the fact that resveratrol has been shown to have some health benefits, and they are selling a product that is not going to provide those same benefits.

Consumers should be aware that they may not be getting what they think they are when they purchase products that contain cis-resveratrol. 

Trans-resveratrol is only the trans form of resveratrol that is active in the body. In addition, Research suggests thay trans-resveratrol is the form that has the health benefits of - longevity, reduced blood pressure, liver support, healthy aging, joint care and brain health.

If the resveratrol is cheap, or they do not specifically say trans-resveratrol. You may want to reconsider in order to get the effects you want.

Another major issue is that resveratrol is difficult to absorb.

In order to maximize the chance of absorption of any dietary supplement or tablet, it should be micronized.

Micronization is the process of making the ingredient into smaller micro particles to enhance the absorption of fat soluble ingredients.

Micronized trans-resveratrol has a much higher chance of being absorbed than non-micronized resveratrol. Super micronized resveratrol is even more effective as it is easier to absorb. It is important to make sure that you are taking a micronized or super micronized form of resveratrol in order to maximise the benefits.

Resveratrol is fat soluble, meaning it will not absorb in water, and it requires a source of fat to be absorbed.

Benefit of NMN with Resveratrol Combination

Resveratrol works synergistically with NMN as it acts as an accelerator to produce better results in DNA repair. Published in Pharmacology Research and Perspectives (2022), Jiang and colleagues from Macau University of Science and Technology in China demonstrated that combining NMN with resveratrol increases NAD+ levels in heart and skeletal muscle of mice significantly more than NMN alone.

Chemical Structures of NMN and Resveratrol

The chemical structure of resveratrol includes an aromatic ring connected to two hydroxyl groups (-OH), while the structure of NMN includes an amide group (-NH2). Both molecules are relatively small in size but contain powerful antioxidant properties.

Best NMN and Resveratol Supplement 2023

  • Prohealth Longevity NMN Pro Complete (NMN, Trans-Resveratrol and TMG)
  • NMN Pro Complete is the first and only perfectly balanced combination of NMN, Trans-Resveratrol and TMG on the market. Instead of having to take three separate supplements each day, you can now get the ideal balance of all three in one convenient serving. A single scoop of NMN Pro Complete will provide you with 1,000 mg of NMN, 1,000 mg of trans-resveratrol, and 500 mg of TMG – the daily dosage most often recommended by the world's leading longevity experts.
  • Suggested use: Take 1 scoop daily under the tongue or dissolved in water, preferably in the morning or as directed by your health care practitioner.
ProHealth Longevity NMN Pro Review:
"Uthever’s research team is led by U.S. doctors from the pharmaceutical giant GlaxoSmithKline. This NMN is tested both in-house by Uthever and then batch-tested again by ProHealth to verify authenticity and purity.
Painstaking attention to quality and purity has led to findings that ProHealth NMN remains intact and stable for up to two years. Pro 300 gets rave reviews, often beating popular products like Genex. Pay attention to price, however, as I’ve seen it fluctuate by nearly $50. I’ve also noticed that there isn’t a GMP-certified logo on the bottle itself. If you want a shelf-stable NMN that lasts, ProHealth Pro 300 is a top choice." -


NMN and resveratrol are two natural compounds that have been shown to have powerful anti-aging properties. By increasing NAD+ levels and reducing inflammation, these supplements can help slow down the aging process, improve cognitive function, and reduce the risk of age-related diseases such as Alzheimer's and diabetes. Furthermore, they may improve cardiovascular health, bone density, and muscle function. While more research is needed to fully understand the potential benefits of NMN and resveratrol, early results are promising, and these supplements are sure to play a key role in the future of anti-aging medicine.



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