Regenerative Medicine 101: What You Need to Know

By Dr Frank Yap, MD -
When you scrape your knee, break a bone, or cut yourself, the body is able to heal itself. But that’s not the case with certain conditions, like diabetes or heart disease.

Regenerative medicine, a fairly new field in which experts are looking for therapies and strategies similar to the mechanisms that help your body heal itself, is changing that.

What Is Regenerative Medicine?

Regenerative medicine first picked up steam in the 1990s when tissue engineering became popular for stem cell research and procedures like skin grafting.

The goal of regenerative medicine is to replace or reboot tissues or organs damaged because of disease, injury, age, or other issues instead of treating symptoms with medication and procedures.

Regeneration in humans happens at three levels:

Molecular. This includes small molecules that are the building blocks of your body, like DNA, fats, and carbohydrates.

Cellular. This includes cell structures like neurons or axons that are responsible for cell growth and reproduction in your body.

Tissue. This includes blood, skin, bone, or muscle.

While many forms of regenerative medicine research are still underway, some have already been put to use. One of them is stem cell therapy. This is when scientists grow specialized stem cells in a lab. Depending on the need, they can be instructed to behave like certain types of cells, such as those in your heart, blood, or nerves.

For example, if you have heart disease, these lab-made heart muscle cells may be used as transplanted tissue to help repair or replace damaged heart cells.

Several therapies and conditions including:

  • Type 1 diabetes
  • Cardiovascular tissue repair
  • Brain injury tissue repair
  • Immune system improvement
  • Cell therapy
  • Tissue engineering
  • Skin wounds
  • Certain cancers
  • Organ transplants

Regenerative medicine continues to take shape with new discoveries and advancements, but there are a few major areas.

They include:

Tissue engineering and biomaterials. This is when biomaterials -- made from three-dimensional (3D) printing using things like metals, ceramics, and polymers called scaffolds -- are put in your body where new tissue needs to grow.

Many people have been treated with this method, but research is ongoing.

Cellular therapies. All of us have millions of adult stem cells. It’s one of the ways our body repairs itself. Studies have shown that if adult stem cells are grouped and injected in areas where there is disease or tissue damage, the stem cells can help reconstruct new tissue under certain conditions.

Adult stem cells can be taken from various parts of your body, such as:

  • Blood
  • Fat
  • Bone marrow
  • Dental pulp
  • Skeletal muscle
  • Cord blood (blood found in the umbilical cord and placenta after birth)

Scientists are conducting studies to learn more about cellular therapy for tissue and organ regeneration.

Medical devices and artificial organs. If your organ is too far gone to function and needs to be replaced, doctors usually recommend organ transplant. But it can be difficult to find organ donors who are the right match, and it often takes a lot of time. Time is of the essence when you’re in need of a new kidney or a lung.

In these cases, regenerative medicine has used engineering and robotics to come up with technologies and machines to support failing organs. For example, your doctor can put a ventricular assistive device (VAD) in the body to help with circulation issues during complex transplant processes.

A lot more research and clinical trials are needed for certain therapies before they can be approved for medical use.

If you or a loved one has an ongoing condition or disease and you’re wondering if regenerative medicine is an option for you, ask your doctor about it.

Regenerative Medicine Market

The global regenerative medicine market size was valued at USD 55.03 billion in 2022 and is expected to expand at a compound annual growth rate (CAGR) of 15.7% from 2023 to 2030. Several advancements in biological therapies have shifted the preference toward personalized medicinal strategies over traditional treatment methods. This has created significant opportunities for market players who are involved in biological therapeutics development. 

The COVID-19 outbreak has considerably impacted various markets, including the regenerative medicine and T-cell therapy manufacturing market. The SARS-CoV-2 coronavirus crisis has significantly affected the delivery of CAR T-cell therapies. 

The global T-Cell therapy market was valued at USD 2.83 billion in 2022 and is projected to grow at a compound annual growth rate (CAGR) of 35.33% from 2023 to 2030 (R).

This impact is not just limited to patient care but has extended to administration, logistics, and limited healthcare resources. Several universities have slowed down clinical trial enrollment and other research activities.



However, the market continues to expand as market players such as Novartis provide access to therapies such as Athersys, Inc.’s MultiStem, which is a highly relevant COVID-19 therapy.

Furthermore, regenerative medicines have been identified to have the unique ability to alter the fundamental mechanisms of diseases. Regenerative therapies in trials provide promising solutions for specific chronic indications with unmet medical needs. In December 2021, Novartis announced the introduction of T-Charge™, a next-generation CAR-T platform that would be a beneficial tool for novel investigational CAR-T cell therapies.

Significant advancements in molecular medicines have resulted in the development of gene-based therapy, which uses targeted delivery of DNA as a medicine to fight against various disorders. Gene therapy has high potential in the treatment of cancer and diabetes type 1 & 2 through restoring gene function. 

The global gene therapy market size was estimated at USD 8.67 billion in 2023 and is projected to grow at a compound annual growth rate (CAGR) of 19.5% from 2024 to 2030. (R)

Currently, gene-based therapies are used in the treatment of patients suffering from cancer, oncology, infectious diseases, cardiovascular disorders, monogenic diseases, genetic disorders, ophthalmological indications, and diseases of the central nervous system. These factors have contributed to the growth of the regenerative medicine market.

Related: Gendicine (Ad-p53), The First Approved Gene Therapy Product for Cancer

Product Insights

The therapeutics segment held a 69.1% revenue share of the regenerative medicine market in 2022, owing to the rising geriatric population, coupled with higher incidence rates of age-related as well as degenerative disorders. The increased prevalence of diseases with unmet medical solutions, such as cancer, diabetes, and neurodegenerative diseases, including AMD, has encouraged researchers to develop alternative options. For instance, in April 2022, Kite, a Gilead Company, announced that it had received the U.S. FDA's authorization for its CAR T-cell therapy product, Yescarta, which could be used for the treatment of refractory or relapsed large B-cell lymphoma.

The banks segment is projected to witness considerable growth in the coming years. Considerable investment has been made to establish bio-banks, including tissue and cord blood banks, to provide the perceived research benefits. These banks comprise systematically organized and maintained cell lines for single or multi-use by researchers, healthcare providers, and other stakeholders. Stem cells and biologically engineered tissues are the most significant tools used in regenerative medicine. Thus, these banks are an important part of the regenerative medicine market.

Therapeutic category Insights

The oncology segment dominated the regenerative medicine market in 2022, capturing a revenue share of 32.3%, owing to the growing burden of cancer globally. Various government organizations along with private companies have made high investments in cancer research and the development of regenerative & advanced cell therapies. In January 2023, Calidi Biotherapeutics (CBT) and First Light Acquisition Group (FLAG) entered into a partnership agreement that aims to revolutionize oncolytic virotherapies with the help of stem cell-based platforms.

The cardiovascular segment is anticipated to witness significant growth during the forecast period. Advancements in cell-based therapies and regenerative medicines have accelerated the growth of the segment. Many key players are involved in the development of regenerative therapies to repair, restore, and revascularize damaged heart tissues. There is a growing adoption of single and mixed cells from autologous as well as allogeneic sources to study the effect on CVDs. In addition, advanced biologics, small molecules, and gene therapy are being investigated to stimulate the regeneration of damaged heart cells. These factors would further fuel the regenerative medicine market growth.


Regional Insights

The North America region dominated the regenerative medicine market, capturing a market share of 51.32% in 2022. The high market growth is attributed to the availability of government and private funding for development, the presence of advanced tech frameworks to support the rapid detection of chronic diseases, and high healthcare spending in the region. Moreover, several ongoing clinical trials for regenerative medicine by significant market players have contributed to the region’s growth. In December 2021, Bristol Myers Squibb received U.S. FDA approval for Orencia for the prevention of acute graft versus host disease in adults and pediatric patients 2 years of age and older, undertaking hematopoietic stem cell transplantation (HSCT).

Key Companies

Major players operating in the regenerative medicine market are focused on strategic partnerships, collaborations, and regional expansions in favorable regions. For instance, in September 2021, AstraZeneca PLC planned to invest USD 360 million in an advanced manufacturing facility in Ireland. This initiative was expected to transform the development and commercialization of novel medicines. In December 2021, Pfizer, Inc. invested USD 68.5 million in a new state-of-the-art facility in Durham to expand its capabilities in gene therapies. This initiative was expected to help strengthen the company’s presence in the U.S.


Sources and References: 

https://www.webmd.com/a-to-z-guides/what-is-regenerative-medicine

https://stemcell.aestheticsadvisor.com/2023/03/regenerative-medicine-market-2023.html

Comments

Post a Comment

Labels

Show more

Popular posts from this blog

10 Best Vitamin C Serums Recommended by Dermatologists 2025

By Dr Frank Yap, MD -
Image
Vitamin C serum is a serum containing vitamin C that you can apply on your skin. This vitamin is vital for skin growth and repair. It helps with collagen production too. Make up can cover blemishes but the best vitamin C serums can resolve what you’re trying to cover up in the first place! All it takes is a few drops once a day to lighten blemishes, hyper pigmentation, acne scars, the start of wrinkles, dull skin, etc. Vitamin C serum has a wide array of benefits, and most of them are what we have been hoping for our skin. Even skin tone, blur fine lines, remove acne spots, and achieve a natural glow. Among all other skincare ingredients and products marketed these days, Vitamin C is simply the queen of them all. No wonder so many dermatologists and beauty experts rave about incorporating vitamin C into your regime. Related: Best Anti Aging Skincare Hong Kong According to the  Indian Dermatology Online Journal , clinical studies have shown that the topical use of vitamin C increase...
Read more

10 Best Vitamin C Serums for Brighter Skin 2024

By Dr Frank Yap, MD -
Image
Vitamin C is an antioxidant which protects skin cells from damaging free radicals caused by UV exposure. It also helps lighten hyperpigmentation and brown spots, even out skin tone, and enhance skin radiance. Best Vitamin C Serums for Brighter Skin  1. Eva Naturals Skin Clearing Serum Vitamin C+, 30ml Buy on Amazon Ratings : 4.3 out of 5 - more than 57,000 global ratings. Key ingredients: 2% Retinol, 3.5% Niacinamide, 5% Hyaluronic Acid, 2% Salicylic Acid, 10% MSM, 20% Vitamin C. The Derm Review Eva Naturals is a boutique cosmetics company known for its Vitamin C Plus Skin Clearing Serum. This serum is Amazon’s best-selling formula in the facial oil category, with over 16,000 glowing 5-star reviews from customers who have seen impressive results. The serum contains a blend of vitamin C, turmeric, vitamin E, and ferulic acid. It’s designed to combat acne, soothe troubled skin, and reduce blemishes. However, if you have highly sensitive skin prone to acne breakouts...
Read more

9 Best Anti Aging Skincare Hong Kong 2025

By Dr Frank Yap, MD -
Image
It’s natural to have complex feelings about noticing signs of aging. You can embrace the beauty and privilege that it is to age, while also not love all of the physical changes that come along with it.  If you’d like to soften these signs but don’t want to go the injectables route, there are non-invasive products that can help. In the world of beauty products, there's perhaps no category more saturated than the anti-aging market. What to Look for in an Anti-Aging Product a. Vitamin C An antioxidant powerhouse, vitamin C is directly involved with collagen production in the body. Vitamin C is beneficial in anti-aging products for several reasons: It protects skin from environmental stressors, promotes cell turnover, and can fade dark spots which contribute to the appearance of aging skin. Products containing vitamin C can irritate sensitive skin, so be sure to start out using a low concentration if your skin is reactive. b. Retinoids Retinoids are a category of ingredients, and retin...
Read more

10 Best Cosmeceutical Ingredients of 2024

By Dr Frank Yap, MD -
Image
A cosmeceutical is essentially a skincare product that contains a biologically active compound that is thought to have pharmaceutical effects on the skin. Both pharmaceutical and cosmeceutical grade skin care products actively effect skin at a cellular level, whereas cosmetic products have a shorter-term effect. They are usually used by doctors to restore pH, remove pigmentation, or restore the skin barrier. Cosmeceuticals must scientifically verify the claims stated on their packaging; as it is accepted that these formulations are backed by science, clinical studies, and rigorous testing. The main areas of concerns that these formulations address are ageing skin, sensitive/sensitized skin, sun damaged skin, acne/oily skin, loss of tone and elasticity, as well as superficial lines & wrinkles to encourage rapid cellular turnover that will renew and re-texturize the skin. Peptides composed of chains of amino acids give proteins their structure, and transport nutrients and signal mess...
Read more

8 Best Vitamin C Serums for Hyperpigmentation 2024

By Dr Frank Yap, MD -
Image
Vitamin C serums are serums that contain vitamin C which you can apply on your skin. These serums have a wide array of benefits. They help even skin tone, blur fine lines, remove acne spots, and achieve a natural glow. They are also vital for skin growth and repair. They help with collagen production too. Data Bridge Market Research analyses that the global pigmentation disorders treatment market, which was USD 6.5 billion in 2022, would rocket up to USD 12.3 billion by 2030 and is expected to undergo a CAGR (compound annual growth rate) of 7.30 % during the forecast period. Reasons for this growth include increased spending on personal care products and a growing prevalence of skin disorders — many of which are due to global warming. Additional reasons for the worldwide market boost include high disposable income, increasing adoption of smoking in young adults, and growing demand from millennials. How Does Vitamin C Treat Hyperpigmentation? ...
Read more

8 Best Vitamin D3 and K2 Supplements 2025: Benefits, Reviews and Prices

By Dr Frank Yap, MD -
Image
Most people in the United States consume less than recommended amounts of vitamin D . An analysis of data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 4.3 mcg in men, 3.8 mcg in women, and 5 mcg (200 IU) in children aged 2–19 years ( NHANES 2017 - 2018 ). What Is Vitamin D? Vitamin D is a fat-soluble vitamin, meaning that it dissolves in fats and oils and can be stored in your body for a long time. Vitamin D is important to the body in many ways. It helps the body absorb calcium from food and supplements. Muscles need it to move, for example, nerves need it to carry messages between the brain and every body part, and the immune system needs vitamin D to fight off invading bacteria and viruses. Together with calcium, vitamin D also helps protect older adults from osteoporosis. Vitamin D is found in cells throughout the body. Vitamin D Market Size The Global Vitamin D Market size was ...
Read more

Biggest Skin-Care Trends of 2024 - Allure

By Dr Frank Yap, MD -
Image
Exosomes, neurocosmetics, and supercharged actives are the most innovative — and sometimes the most controversial — skin-care trends poised to revolutionize beauty in the next few years. We pored over the data and talked with experts to give you a snapshot of the top skin-care trends of 2024. Regenerative medicine will inspire your skin care. This year skin care won’t focus solely on addressing the signs of aging; it’s going to try to make cells behave younger, says Steven Cohen , MD, a board-certified plastic surgeon in San Diego. As with so many skin-care trends that have come before, this one is rooted in medicine — in this case, regenerative medicine, which is centered on developing and applying therapies to help the body heal itself. For example, stem cells — those biological blank slates that can turn into new skin, cartilage, or bone — are currently used in oncology to help the body produce new blood cells after high doses of chemotherapy. Again, this may sound like sci-fi (a t...
Read more

8 Best Eye Creams for Dark Circles Hong Kong 2024

By Dr Frank Yap, MD -
Image
Dark circles is a common cosmetic concerns that can make us look tired, stressed, and older than our actual age. They are distinguished by coloring or pigmentation around the eyes. Many factors, such as genetics, aging, lifestyle choices, underlying medical conditions, and UV exposure, can contribute to the development of dark circles.  There are several home remedies available to reduce the appearance of dark circles, however, it may not be practical for individuals with busy lifestyles since it often requires time and effort to prepare and apply. Therefore, the cream can be the best option! What Causes Dark Undereye Circles? - by Popsugar.co The skin around our eyes is thinner and a lot more delicate, making it more susceptible to external aggressors and damage.  "The eyelids are very vascular, and the eyelid skin is very thin; this will make them more apparent under the eyelid skin and cause the appearance of dark circles," Miss Elizabeth Hawkes, consultant ophthalmic and...
Read more

Fenbendazole Joe Tippens Protocol: A Step-by-Step Guide

By Dr Frank Yap, MD -
Image
If you have been diagnosed with cancer, or have a loved one that is suffering from cancer, chances are you have heard about the Joe Tippens Cancer Protocol. The Fenbendazole Cancer Protocol has been gaining rapid interest over the past years following some fenbendazole advanced cancer success stories. Joe Tippens founded the protocol after he was told a story about a scientist at Merck Animal Health that had been performing cancer research on mice. The research included injecting different types of cancers into different mice body parts. The scientists discovered, through trial and error, a product in their canine product line, fenbendazole, that was batting 1.000 in killing these different cancers in the mice. The scientist was later diagnosed with stage 4 brain cancer and was given a grim prognosis of only three months to live. She decided to try the fenbendazole, and after six weeks, showed a clean scan. Joe Tippens had been initially diagnosed with small...
Read more

6 Best Organic Vitamin D3 and K2 Supplements 2025

By Dr Frank Yap, MD -
Image
In recent weeks and months, several publications and studies have suggested that maintaining adequate levels of vitamin D would seem potentially beneficial in fighting the COVID-19 infection. How do you know that your vitamin D level is adequate? Most people in the United States consume less than recommended amounts of vitamin D. An analysis of data from the 2015–2016 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 5.1 mcg (204 IU) in men, 4.2 mcg (168 IU) in women, and 4.9 mcg (196 IU) in children aged 2–19 years ( NHANES ). What Is Vitamin D? Vitamin D is a fat-soluble vitamin, meaning that it dissolves in fats and oils and can be stored in your body for a long time. Vitamin D is important to the body in many ways. It helps the body absorb calcium from food and supplements. Muscles need it to move, for example, nerves need it to carry messages between the brain and every body part, and the immune syste...
Read more

Archive

Show more