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Why a Weight-Loss Pill Is Still a Big Deal — Heard on the Street — Wall Street Journal

By Dr Frank Yap, MD -
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Weight-loss injections such as Wegovy and Zepbound have already reshaped medicine and raked in billions of dollars in sales — but they have barely scratched the surface. In the U.S. where adoption is highest, fewer than 1 in 10 adults are on a GLP-1 drug, despite nearly three-quarters being overweight or obese. Globally access is even more limited, held back by high costs, strict coverage requirements and supply shortages. A pill could change all that. Cheaper to make, easier to distribute and simpler to take, an oral weight-loss drug could finally bring obesity treatment to the masses. Wall Street, however, seems to have soured on the opportunity. On Thursday, Eli Lilly lost over $100 billion in market capitalization, with the stock falling 14% after the company reported underwhelming results for its much-anticipated pill, orforglipron. Patients on the highest dose of the drug lost an average of 12.4% of their body weight after more than a year. Lilly's injectable drug Zepbound ha...
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7 Best Organic Vitamin D3 and K2 Supplements 2025

By Dr Frank Yap, MD -
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In recent weeks and months, several publications and studies have suggested that maintaining adequate levels of vitamin D would seem potentially beneficial in fighting the COVID-19 infection. How do you know that your vitamin D level is adequate? Most people in the United States consume less than recommended amounts of vitamin D. An analysis of data from the 2015–2016 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 5.1 mcg (204 IU) in men, 4.2 mcg (168 IU) in women, and 4.9 mcg (196 IU) in children aged 2–19 years ( NHANES ). What Is Vitamin D? Vitamin D is a fat-soluble vitamin, meaning that it dissolves in fats and oils and can be stored in your body for a long time. Vitamin D is important to the body in many ways. It helps the body absorb calcium from food and supplements. Muscles need it to move, for example, nerves need it to carry messages between the brain and every body part, and the immune syste...
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Can Diet and Lifestyle influence your Risk of getting Cancer? 1,000+ Studies Analyzed (2024)

By Dr Frank Yap, MD -
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Can diet, supplements and lifestyle influence cancer risk? Dive into 1,000+ research studies to find out. Most of us know Steve Jobs, Chadwick Boseman (Black Panther), Robin Gibb (Bee Gees), Donna Summer, Farrah Fawcett, Eartha Kitt, Peter Jennings, Paul Newman, Patrick Swayze, Sydney Pollack, Michael Crichton, Bob Denver, Ted Kennedy, Jerry Orbach, Anne Bancroft, William Rehnquist, and Tony Snow, just to name a few. What do they have in common? They all died from 'cancer'. Current large language models (LLMs) like ChatGPT, Gemini from Google and Copilot from Microsoft might return generic answers to your questions. While these can be a starting point, they often lack the depth you might crave. That's where this article comes in. We've delved into the research to provide you with more than just basic advice. We've done the research, so that you don't have to. We'll not only share supporting evidence, but also explain our me...
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8 Best Vitamin D3 and K2 Supplements 2025: Benefits, Reviews and Prices

By Dr Frank Yap, MD -
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Most people in the United States consume less than recommended amounts of vitamin D . An analysis of data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 4.3 mcg in men, 3.8 mcg in women, and 5 mcg (200 IU) in children aged 2–19 years ( NHANES 2017 - 2018 ). What Is Vitamin D? Vitamin D is a fat-soluble vitamin, meaning that it dissolves in fats and oils and can be stored in your body for a long time. Vitamin D is important to the body in many ways. It helps the body absorb calcium from food and supplements. Muscles need it to move, for example, nerves need it to carry messages between the brain and every body part, and the immune system needs vitamin D to fight off invading bacteria and viruses. Together with calcium, vitamin D also helps protect older adults from osteoporosis. Vitamin D is found in cells throughout the body. Vitamin D Market Size The Global Vitamin D Market size was ...
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Ivermectin and Fenbendazole in the Treatment of Psoriasis? A Case Series of 13 Patients (2025)

By Dr Frank Yap, MD -
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Abstract Psoriasis is a chronic autoimmune condition affecting approximately 7.5 million individuals in the United States, with significant economic, physical, and psychological burdens. This case series reports on 13 patients who experienced notable improvements in psoriasis symptoms following treatment with ivermectin and/or fenbendazole, antiparasitic agents repurposed for this indication. Cases were derived from self-reported testimonials shared on social media platforms. Treatment durations ranged from 3 days to 3 months, with dosages varying between 6 mg ivermectin twice daily and combinations with fenbendazole. Rapid resolution of skin lesions was observed in most cases, with some achieving near-complete clearance. While these anecdotal reports suggest potential therapeutic efficacy, controlled clinical trials are warranted to validate these findings and elucidate underlying mechanisms. Introduction Psoriasis is a chronic inflammatory disorder characterized by hyperproliferation...
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9 Best Calcium, Magnesium, Vitamin D3 and K2 Supplements 2025

By Dr Frank Yap, MD -
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Calcium, magnesium, vitamin D and Vitamin K2 are vitamin and minerals that are vital to several bodily processes. Though they occur naturally in a variety of foods, many people take supplements to help increase their intake. Benefits and uses 1. May support bone health Calcium is the main mineral in your bones, which hold more than 99% of your body’s calcium stores. Your body is constantly regenerating its bone tissue, so it’s important to consume an adequate amount of this mineral daily ( bones.nih.gov ). Magnesium plays a key role in converting vitamin D into its active form, which aids calcium absorption ( Trusted Source ). Therefore, you can minimize your vitamin D requirement by making sure you’re also getting enough magnesium. Research has confirmed higher magnesium intake helps reduce your risk of vitamin D deficiency by activating more of it.  A  groundbreaking 2017 review  compiled over 80 studies that show vitamin D3 and K2 together might be greater than...
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12 Best Natural Ozempic Alternatives 2025 (Resource Guide)

By Dr Frank Yap, MD -
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If there's anything the Ozempic craze has taught us, it's that people are hungry for weight loss solutions. But as the world leans into wellness, many are now looking beyond pharmaceuticals, turning their gaze to nature's arsenal for blood sugar balance and metabolic health. The 2023 report from the World Obesity Federation estimates that the economic impact of overweight and obesity will surpass $4.3 trillion annually by 2035. In the U.S., the CDC  reports the prevalence of obesity in adults was 41.9% measured from 2017 to March 2020. This represented an increase from 30.5% from 1999 to 2000. The estimated annual medical costs were roughly $173 billion in 2019 dollars. The weight loss and weight management diet market size was valued at 192.2 billion in 2019, and is projected reach $295.3 billion by 2027, registering a CAGR of 7.0% from 2021 to 2027. ( source ) Prescriptions for semaglutide have doubled since mid-2021, rising to mor...
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10 Best Nasal Sprays for COVID-19 (2024)

By Dr Frank Yap, MD -
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Do nasal sprays actually work against COVID-19? Can I use nasal spray if I have COVID-19?  The COVID-19 pandemic has been roaring on for 3 years. During this time, the FDA has authorized many treatments  that help combat COVID-19. COVID-19 vaccines have also been recommended by the CDC ever since the first ones were authorized in December 2020. However, medications that are already authorized are just a small percentage of what's been studied. Many researchers are still trying to find and develop other medications that can treat or prevent COVID-19. Among these, nasal sprays have caught the attention of many people. They’re often easy to use, and some researchers believe they could have a potential impact on the ongoing pandemic. But are any of them effective at treating or preventing COVID-19? And are any of them close to being available in the U.S.?  Which nasal sprays have been studied to treat or prevent COVID-19? A number of nasal sp...
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10 Best Vitamin C Serums for Brighter Skin 2025

By Dr Frank Yap, MD -
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Vitamin C is an antioxidant which protects skin cells from damaging free radicals caused by UV exposure. It also helps lighten hyperpigmentation and brown spots, even out skin tone, and enhance skin radiance. Best Vitamin C Serums for Brighter Skin  1. Eva Naturals Skin Clearing Serum Vitamin C+, 30ml Buy on Amazon Ratings : 4.3 out of 5 - more than 57,000 global ratings. Key ingredients: 2% Retinol, 3.5% Niacinamide, 5% Hyaluronic Acid, 2% Salicylic Acid, 10% MSM, 20% Vitamin C. The Derm Review Eva Naturals is a boutique cosmetics company known for its Vitamin C Plus Skin Clearing Serum. This serum is Amazon’s best-selling formula in the facial oil category, with over 16,000 glowing 5-star reviews from customers who have seen impressive results. The serum contains a blend of vitamin C, turmeric, vitamin E, and ferulic acid. It’s designed to combat acne, soothe troubled skin, and reduce blemishes. However, if you have highly sensitive skin prone to acne breakouts...
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7 Best Cetylpyridinium Chloride Mouthwash Brands 2025

By Dr Frank Yap, MD -
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A meta-analysis of 3 studies (C19early 2025) concluded that CPC (CetylPyridinium Chloride) may significantly lower risk with  viral clearance . One study shows significant benefit. Meta analysis using the most serious outcome reported shows 83% [6‑97%] lower risk . Results are consistent with early treatment being more effective than late treatment. A study, published in Nature ( Takeda 2022 ) concluded that CPC (CetylPyridinium Chloride) may inhibit SARS-CoV-2 infection even at lower concentrations. Another team of international scientists has also demonstrated the usefulness of cetylpyridinium chloride-containing mouthwashes in inhibiting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and reducing the risk of viral transmission. The study is published in the Journal of Medical Microbiology (2022). A scientific review, published in the  Journal of Formosan Medical Association  (2022) also concluded that mouthwash containing CPC shows potential fo...
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