Xlear Nasal Spray COVID-19: Studies Conclude Xlear Kills SARS-CoV-2 and Effective Against New Variants

An in-vitro study done collaboratively by Utah State University and Northwestern University finds Xlear components (grapefruit seed extract and xylitol) significantly eliminates SARS-CoV-2, the virus that causes COVID-19. The imaging research study component was performed at the BioCryo facility of Northwestern University’s NUANCE Center.
Xlear Nasal Spray COVID-19 
Using electron microscopy, we have visual evidence showing that xylitol and grapefruit seed extract (GSE) counters the virus. The GSE kills the virus, while the xylitol prevents the virus from attaching to the cell walls. The image shows SARS-CoV-2 viruses outside the cell and never attached, thereby preventing infection (Photo: Business Wire) 

The study tested SARS-CoV-2 virus titers and LRV against a single concentration of Xlear nasal spray. According to the Study, “After a 25-minute contact time, the nasal spray reduced virus from 4.2 to 1.7 log10 CCID50 per 0.1 mL, a statistically significant reduction (P<0.001) of 2.5 log10 CCID50.” The Northwestern/Utah State Study is the newest in a string of studies to reach the conclusion that Xlear is effective against the SARS-CoV-2.

However, the study breaks new ground in two vital respects: “First, we conclude, in addition to countering SARS-CoV-2, Xlear is likely effective in preventing the spread of future H1N1 viruses, including the emerging SARS-CoV-2 variants, along with other viral epidemics. Given the more transmissible variants we now face, this is critical now,” said Professor Mark Cannon, Feinberg School of Medicine, Northwestern University. “Second, using electron microscopy, we have visual evidence showing that xylitol and GSE counters the virus. The GSE kills the virus, while the xylitol prevents the virus from attaching to the cell walls. The image (attached) shows SARS-CoV-2 viruses outside the cell and never attached, thereby preventing infection,” added Dr. Cannon. The study postulates that xylitol acts as a decoy target for SARS-CoV-2, preventing virus attachment to the core protein on the cell wall.

The collaborative study concludes: “Because there are no risk factors in using the X/GSE combination therapy, and [Xlear] nasal spray is over the counter available without prescription, and [Xlear] allows for comfortable long term mask wearing, adoption of this preventive anti-viral therapy should be encouraged.”

Full study: https://www.biorxiv.org/content/10.1101/2020.12.02.408575v3.full

Where Can I Buy Xlear nasal spray: Xlear nasal spray is available and can be obtained from Amazon.


May 2021: Xlear CEO explains Xlear Nasal Spray’s lasting role against COVID-19

According to Nathan Jones, CEO of Xlear:

With all of the research supporting Xlear, we have applied for an “emergency use authorization” with the FDA. We have five in vitro studies showing how our nasal spray affects the SARS-CoV-2 virus, we have a good understanding of the method of action of how the xylitol blocks adhesion, we have small in-human trials of COVD-19 patients showing great results and we have two larger trials underway right now.

March 2021: Xlear Submits COVID-19 Pre-Emergency Use Authorization Request with FDA Regarding Use of Xlear Nasal Spray in Help in Combating SARS-CoV-2

Xlear has filed a Pre-Emergency Use Authorization (Pre-EUA) Request with the U.S. Food and Drug Administration (FDA) seeking approval to make claims that the nasal spray is approved for use in preventing SARS-CoV-2 (COVID-19) transmission and infection (BusinessWire). The Pre-EUA is a first step in seeking formal authorization of Xlear Nasal Spray as tool to help in combatting COVID-19.

Xlear previously filed a pre-EUA seeking approval for use of the nasal spray as a medical device in combatting COVID-19. However, because the FDA determined that Xlear “works against the virus,” the FDA told Xlear it would need to be considered as a drug or combination product EUA.

“Seeing that the FDA says Xlear works against the virus, we have decided to seek EUA approval as a drug,” said Nathan Jones, Xlear’s CEO.

Xlear’s Pre-EUA Request is based on recent studies showing the nasal spray is:
  • virucidal (it kills the virus);
  • antiviral (it blocks the adhesion of the virus to the nasal membrane, which is how most people get sick from COVID-19);
  • antibacterial against streptococcus bacteria, which is the leading cause of bacterial pneumonia (a COVID-19 complication linked to morbidity); and,
  • Reduces both the duration and severity of illness when used to treat COVID-19 patients.
Xlear is currently sold in over 50,000 pharmacies, grocery stores, and online as a nasal spray. “Xlear doesn’t require the EUA to be sold and used—we only need an EUA to be able to inform people about the benefits of using Xlear to protect themselves from COVID-19. It’s insane. Without the EUA, the Federal Trade Commission won’t let us simply inform people about new, published, independent scientific studies,” Jones added.

“We hope to move forward quickly with FDA to address gaps in current prevention and treatment strategies against SARS-CoV-2. People should be using Xlear as part of a layered defense to prevent getting COVID-19. If everyone used Xlear, in addition to taking other steps recommended by public health officials, we believe we could help the nation defeat COVID-19 faster,” Jones added.

Xlear Xylitol Nasal Spray Active Ingredients

Xlear’s xylitol nasal spray recipe only contains four simple ingredients i.e. Purified Water, Xylitol, Saline, Grapefruit Seed Extract.

We’re going to dive in into their xylitol nasal spray recipe for you.

Purified Water: You hear a lot of talk about purified water, but what does “purified” actually mean? Purified water can come from any source because it goes through the purification process. The purification process removes any chemicals or contaminants that may be in the water. It can be purified several ways including distillation, deionization, reverse osmosis, and carbon filtration.

Xylitol: So what is xylitol? Xylitol is a naturally occurring carbohydrate that looks and tastes just like table sugar. It is widely found in nature, mostly in fruits and vegetables, but is also produced in small amounts by the human body. 

So why did Xlear put a sweetener in their nasal spray recipe? Xlear Inc. actually began when they licensed the nasal spay and the name from the Texas physician and his wife who put the combination together to prevent their grand daughter’s recurring ear infections. They tell their story and why preventing ear infections is much better than treating them here. The spray worked so well his step son suggested they patent it. Then he went to the FDA. “I have a really neat way to wash the nose,” he told them. “We don’t have a category for nose washing, they replied, “What does that do?” He told them, “If your nose is clean you don’t get ear and sinus infections, and allergies and asthma are better.” “Then it’s a drug,” they said. So he went to the pharmaceutical industry. Initial interest there evaporated when they found out that xylitol was a natural product and widely available. If this industry cannot control a product and make the profits needed to get passed by the FDA there is no interest. So they began selling their nose wash through local health food stores. Nathan Jones contacted them and persuaded them that he could market it better than they could. That’s how Xlear in Utah got started.

Research has shown that xylitol makes it harder for infectious germs to hold on in the nose and if they cannot hold on they are easily washed out and are not there to cause infections. Research has also shown that our noses need an adequate amount of water in the air we breathe in order for our defenses there to work properly. Xylitol pulls small amounts of water into the nose, which works to optimize our own nasal defenses. If the defense of your favorite football team is optimal the other team will not score; that seems to be what xylitol does when it’s sprayed regularly into the nose. Since xylitol reduces the germs, pollutants and irritants from holding on in the nose and enhances our own washing defenses regular use of a xylitol nasal spray results in fewer respiratory infections and easier breathing to name some of the xylitol health benefits. In a nutshell, xylitol helps cleanse and moisturize the nasal passageway, the “drug” benefits are secondary to the cleaning.

Saline: First, what is saline? A lot of people are aware of it, but for those who aren’t, let us explain. Saline is plain and simply salt water. So why is saline an excellent addition to a xylitol nasal spray recipe?

Saline solution is salt water that contains 0.9 percent salt. It has a similar salt and water composition as a person's blood and tears. Saline solutions can help restore moisture to the nasal passages and sinuses. It can also help with inflammation and thinning the mucus.

Grapefruit Seed Extract: Xlear’s xylitol nasal spray recipe includes grapefruit seed extract (GSE) as a natural preservative. GSE is derived from the seeds, membranes, and the pulp of the grapefruit. It is often used as a purifier, antiseptic, and preservative.

That’s it! That’s everything in Xlear’s xylitol nasal spray recipe. Because their nasal spray doesn’t contain any steroids or other anti-inflammation products, you will never have to worry about rebound congestion using Xlear Nasal Spray. Xlear recommends using their product daily, in the morning and evening. However, you can use it whenever you’re feeling a little stuffed up due to a cold or flu or simply allergies. 

Note: Do not get confused between Xlear Nasal Spray (with Xylitol) and Xlear Nasal Decongestant. Xlear nasal decongestant is a different product and contains oxymetazoline instead.

Xylitol: Evidence and Studies


About Xlear Inc.

Since it was formed in 2000, Xlear Inc. (pronounced “clear”) has been recognized as the leading manufacturer of xylitol-based products in North America.

Where To Buy Xlear nasal spray?

Xlear nasal spray is available in stores near you and can be obtained online from Amazon. Available for adults and kids:


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