Xlear Nasal Spray COVID-19: Study Concludes Xlear Kills and/or Deactivates SARS-CoV-2; Efficacy Against New Variants

An in-vitro study done collaboratively by Utah State University and Northwestern University finds Xlear components (grapefruit seed extract and xylitol) significantly eliminates SARS-CoV-2, the virus that causes COVID-19. The imaging research study component was performed at the BioCryo facility of Northwestern University’s NUANCE Center.
 
Xlear Nasal Spray COVID-19 
Using electron microscopy, we have visual evidence showing that xylitol and grapefruit seed extract (GSE) counters the virus. The GSE kills the virus, while the xylitol prevents the virus from attaching to the cell walls. The image shows SARS-CoV-2 viruses outside the cell and never attached, thereby preventing infection (Photo: Business Wire) 

The study tested SARS-CoV-2 virus titers and LRV against a single concentration of Xlear nasal spray. According to the Study, “After a 25-minute contact time, the nasal spray reduced virus from 4.2 to 1.7 log10 CCID50 per 0.1 mL, a statistically significant reduction (P<0.001) of 2.5 log10 CCID50.” The Northwestern/Utah State Study is the newest in a string of studies to reach the conclusion that Xlear is effective against the SARS-CoV-2.

However, the study breaks new ground in two vital respects: “First, we conclude, in addition to countering SARS-CoV-2, Xlear is likely effective in preventing the spread of future H1N1 viruses, including the emerging SARS-CoV-2 variants, along with other viral epidemics. Given the more transmissible variants we now face, this is critical now,” said Professor Mark Cannon, Feinberg School of Medicine, Northwestern University. “Second, using electron microscopy, we have visual evidence showing that xylitol and GSE counters the virus. The GSE kills the virus, while the xylitol prevents the virus from attaching to the cell walls. The image (attached) shows SARS-CoV-2 viruses outside the cell and never attached, thereby preventing infection,” added Dr. Cannon. The study postulates that xylitol acts as a decoy target for SARS-CoV-2, preventing virus attachment to the core protein on the cell wall.

The collaborative study concludes: “Because there are no risk factors in using the X/GSE combination therapy, and [Xlear] nasal spray is over the counter available without prescription, and [Xlear] allows for comfortable long term mask wearing, adoption of this preventive anti-viral therapy should be encouraged.”

Full study: https://www.biorxiv.org/content/10.1101/2020.12.02.408575v3.full

Where Can I Buy Xlear nasal spray: Xlear nasal spray is available and can be obtained from Amazon.

Update (May 2021): Xlear CEO explains Xlear Nasal Spray’s lasting role against COVID-19

According to Nathan Jones, CEO of Xlear:

With all of the research supporting Xlear, we have applied for an “emergency use authorization” with the FDA. We have five in vitro studies showing how our nasal spray affects the SARS-CoV-2 virus, we have a good understanding of the method of action of how the xylitol blocks adhesion, we have small in-human trials of COVD-19 patients showing great results and we have two larger trials underway right now.

Update (March 2021): Xlear Submits COVID-19 Pre-Emergency Use Authorization Request with FDA Regarding Use of Xlear Nasal Spray in Help in Combating SARS-CoV-2

Xlear has filed a Pre-Emergency Use Authorization (Pre-EUA) Request with the U.S. Food and Drug Administration (FDA) seeking approval to make claims that the nasal spray is approved for use in preventing SARS-CoV-2 (COVID-19) transmission and infection (BusinessWire). The Pre-EUA is a first step in seeking formal authorization of Xlear Nasal Spray as tool to help in combatting COVID-19.

Xlear previously filed a pre-EUA seeking approval for use of the nasal spray as a medical device in combatting COVID-19. However, because the FDA determined that Xlear “works against the virus,” the FDA told Xlear it would need to be considered as a drug or combination product EUA.

“Seeing that the FDA says Xlear works against the virus, we have decided to seek EUA approval as a drug,” said Nathan Jones, Xlear’s CEO.

Xlear’s Pre-EUA Request is based on recent studies showing the nasal spray is:
  • virucidal (it kills the virus);
  • antiviral (it blocks the adhesion of the virus to the nasal membrane, which is how most people get sick from COVID-19);
  • antibacterial against streptococcus bacteria, which is the leading cause of bacterial pneumonia (a COVID-19 complication linked to morbidity); and,
  • Reduces both the duration and severity of illness when used to treat COVID-19 patients.
Xlear is currently sold in over 50,000 pharmacies, grocery stores, and online as a nasal spray. “Xlear doesn’t require the EUA to be sold and used—we only need an EUA to be able to inform people about the benefits of using Xlear to protect themselves from COVID-19. It’s insane. Without the EUA, the Federal Trade Commission won’t let us simply inform people about new, published, independent scientific studies,” Jones added.

“We hope to move forward quickly with FDA to address gaps in current prevention and treatment strategies against SARS-CoV-2. People should be using Xlear as part of a layered defense to prevent getting COVID-19. If everyone used Xlear, in addition to taking other steps recommended by public health officials, we believe we could help the nation defeat COVID-19 faster,” Jones added.

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