Reviews on skin specialists in Malaysia

By Dr Frank Yap, MD -
Reviews on skin specialists in Malaysia

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Ivermectin and Fenbendazole in the Treatment of Psoriasis? A Case Series of 13 Patients (2025)

By Dr Frank Yap, MD -
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Abstract Psoriasis is a chronic autoimmune condition affecting approximately 7.5 million individuals in the United States, with significant economic, physical, and psychological burdens. This case series reports on 13 patients who experienced notable improvements in psoriasis symptoms following treatment with ivermectin and/or fenbendazole, antiparasitic agents repurposed for this indication. Cases were derived from self-reported testimonials shared on social media platforms. Treatment durations ranged from 3 days to 3 months, with dosages varying between 6 mg ivermectin twice daily and combinations with fenbendazole. Rapid resolution of skin lesions was observed in most cases, with some achieving near-complete clearance. While these anecdotal reports suggest potential therapeutic efficacy, controlled clinical trials are warranted to validate these findings and elucidate underlying mechanisms. Introduction Psoriasis is a chronic inflammatory disorder characterized by hyperproliferation...
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8 Best Vitamin D3 and K2 Supplements 2025: Benefits, Reviews and Prices

By Dr Frank Yap, MD -
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Most people in the United States consume less than recommended amounts of vitamin D . An analysis of data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 4.3 mcg in men, 3.8 mcg in women, and 5 mcg (200 IU) in children aged 2–19 years ( NHANES 2017 - 2018 ). What Is Vitamin D? Vitamin D is a fat-soluble vitamin, meaning that it dissolves in fats and oils and can be stored in your body for a long time. Vitamin D is important to the body in many ways. It helps the body absorb calcium from food and supplements. Muscles need it to move, for example, nerves need it to carry messages between the brain and every body part, and the immune system needs vitamin D to fight off invading bacteria and viruses. Together with calcium, vitamin D also helps protect older adults from osteoporosis. Vitamin D is found in cells throughout the body. Vitamin D Market Size The Global Vitamin D Market size was ...
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Isoquercetin vs Quercetin vs Quercetin Phytosome 2023: What's the Difference?

By Dr Frank Yap, MD -
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Quercetin is a type of flavonoid present in many fruits, vegetables, and grains. It’s one of the most abundant antioxidants in the diet and plays an important role in helping your body combat free radical damage, which is linked to chronic diseases. In addition, its antioxidant properties may help reduce inflammation, allergy symptoms, and blood pressure. Isoquercetin vs Quercetin Quercetin and isoquercetin are both natural plant flavonoids. Quercetin is an aglycone, meaning that it lacks a glycoside side chain. In contrast, naturally occurring quercetin compounds are primarily glycosides, with only very small quantity occurring as an aglycone. Once absorbed from the gut, most quercetin compounds are metabolized to quercetin glucuronides, the primary metabolic form detected in plasma. As mentioned, quercetin does not principally occur in the form in which it is available as a dietary supplement (an aglycone). Instead, it occurs mostly as quercetin glycosides. Isoquercetin is one ...
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7 Best Organic Vitamin D3 and K2 Supplements 2025

By Dr Frank Yap, MD -
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In recent weeks and months, several publications and studies have suggested that maintaining adequate levels of vitamin D would seem potentially beneficial in fighting the COVID-19 infection. How do you know that your vitamin D level is adequate? Most people in the United States consume less than recommended amounts of vitamin D. An analysis of data from the 2015–2016 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 5.1 mcg (204 IU) in men, 4.2 mcg (168 IU) in women, and 4.9 mcg (196 IU) in children aged 2–19 years ( NHANES ). What Is Vitamin D? Vitamin D is a fat-soluble vitamin, meaning that it dissolves in fats and oils and can be stored in your body for a long time. Vitamin D is important to the body in many ways. It helps the body absorb calcium from food and supplements. Muscles need it to move, for example, nerves need it to carry messages between the brain and every body part, and the immune syste...
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7 Best Cetylpyridinium Chloride Mouthwash Brands 2025

By Dr Frank Yap, MD -
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A meta-analysis of 3 studies (C19early 2025) concluded that CPC (CetylPyridinium Chloride) may significantly lower risk with  viral clearance . One study shows significant benefit. Meta analysis using the most serious outcome reported shows 83% [6‑97%] lower risk . Results are consistent with early treatment being more effective than late treatment. A study, published in Nature ( Takeda 2022 ) concluded that CPC (CetylPyridinium Chloride) may inhibit SARS-CoV-2 infection even at lower concentrations. Another team of international scientists has also demonstrated the usefulness of cetylpyridinium chloride-containing mouthwashes in inhibiting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and reducing the risk of viral transmission. The study is published in the Journal of Medical Microbiology (2022). A scientific review, published in the  Journal of Formosan Medical Association  (2022) also concluded that mouthwash containing CPC shows potential fo...
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Retatrutide vs Tirzepatide vs Semaglutide (Ozempic): GLP-1 Wars

By Dr Frank Yap, MD -
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Introduction The landscape of obesity treatment has evolved dramatically with the introduction of advanced medical therapeutics like retatrutide (RETA, LY3437943), tirzepatide (Mounjaro), and semaglutide (Ozempic). These drugs, originally developed to manage type 2 diabetes, have shown remarkable efficacy in promoting weight loss, making them game-changers for obesity management. However, each drug has unique mechanisms, benefits, and potential applications, including emerging roles in cancer prevention. This article compares retatrutide, tirzepatide, and semaglutide, highlighting their differences in mechanism of action, weight loss efficacy, additional health benefits, and side effects to help patients and healthcare providers make informed decisions. Update: Are GLP-1s the first longevity drugs ? (Nature 2025) Credit: GoodRx Health Mechanism of Action Semaglutide : Semaglutide (Ozempic and Wegovy) is a glucagon-like peptide-1 receptor agonist (GLP-1 RA). It mimics the action of GLP...
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Natto vs Nattokinase vs Nattozimes: What's the Difference?

By Dr Frank Yap, MD -
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Marketing geniuses have positioned soy as the wonder health alternative to virtually everything. In most supermarkets, you’ll find soy milk, soy protein, soybean oil, soy lecithin and even soy soap. Unfortunately, though, many forms of soy are not necessarily as healthy as food manufacturers would like you to believe. The problem is the soy you see in all these foods is not the traditionally grown crop of Japan. In fact, the majority of soy that you find in in grocery stores is actually genetically modified (GMO), produced in a different way and doesn’t yield the same nutritional benefits. However, when you ferment soybeans you have a completely different product that boasts an entirely separate set of nutrients, which is why when it comes to soy, the safest and best way to consume it is through fermented foods like miso, tempeh or natto. So what is natto, and how can it impact your health? Let’s dig in. What is Natto? Natto is a popular food in Japan, and is made by fermenting soybean...
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Low Carb, Cortisol and Glucose: What You Need to Know (2025)

By Dr Frank Yap, MD -
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This interview (below) features repeat guest Georgi Dinkov who is a virtual firehose of information and an expert on the work of the late Ray Peat (1,2) Ph.D., an author and pioneer in nutrition, bioenergetic medicine, environmental factors and regenerative processes. Some of the information in this interview will challenge some of your long held views as it did mine. We all have conformational biases and I encourage you to let yours go for awhile and consider the possibility that some of this information might be true for you and others. This is among the best interviews I’ve done in years, and we take deep dives into a wide variety of topics. The full interview is over three hours long, so I’m dividing it into two parts. This is Part 1. This year, on a near-daily basis, I’ve been listening to Dinkov’s podcast for two to three hours at a stretch, and I sometimes repeat them two or three times, because each episode is just so chockful of information. If you want...
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Difference Between NAD+ and NADH?

By Dr Frank Yap, MD -
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What's the difference between NAD and NADH ? Due to the small alphabetical difference, these nutrients are often mixed up and confused by most consumers.  NAD+, or nicotinamide adenine dinucleotide, is a coenzyme found in every single living cell. But sometimes it’s referred to, colloquially, as just NAD (no plus). That plus sign matters, though, because the term NAD is used to collectively refer to the different forms of NAD: the molecules NAD+ and NADH. We will cover the essentials and explain about each of these nutrients below. NAD NAD or nicotinamide adenine dinucleotide is derived from Nicotinamide Riboside (NR). NR is one of the 3 main forms of Niacin (vitamin B3). NAD+ is a substrate for a number of important enzymes, including poly(ADP-ribose) polymerase (PARP) and sirtuin 1 (SIRT1), which is known as a classic longevity protein. NAD+ is also essential in metabolic processes such as creating ATP in your mitochondria. It accepts and donates electrons and is used in oxidatio...
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10 Foods to Boost Your Immune System 2025

By Dr Frank Yap, MD -
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Feeding your body certain foods may help keep your immune system strong. Here is the list. BEST FOODS TO BOOST YOUR IMMUNE SYSTEM 1. Anti-Inflammatory Diet One diet synonymous with anti-inflammatory properties is the Mediterranean diet, which is characterized by a relatively high dietary intake of minimally processed fruit, vegetables, legumes, olive oil, whole grains, nuts, and monounsaturated fats, followed by low-to-moderate consumptions of fermented dairy products, fish, poultry, wine, and, lastly, low consumptions of processed and red meats  [ PubMed ,  PubMed ] . A balanced diet rich in these foods is associated with anti-inflammatory and immunomodulatory compounds, including essential vitamins (C, D, and E) and minerals (zinc, copper, calcium, etc.), that affect a person’s nutri...
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