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Best Vitamin D3 + K2 Supplements in 2026: Doctor-Reviewed Picks for Bone, Heart & Immune Health

By Dr Frank Yap, MD -
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Vitamin D3 and Vitamin K2 are two of the most commonly deficient—and misunderstood—nutrients today. While Vitamin D improves calcium absorption, Vitamin K2 determines where that calcium actually goes . That’s why taking Vitamin D without K2 may be incomplete—and in some cases counterproductive. After reviewing ingredient quality, dosing accuracy, brand transparency, and real-world user feedback, the following are the best Vitamin D3 + K2 supplements available in 2026 . Most people in the United States consume less than recommended amounts of vitamin D . An analysis of data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 4.3 mcg in men, 3.8 mcg in women, and 5 mcg (200 IU) in children aged 2–19 years ( NHANES 2017 - 2018 ). Why Trust This Guide? This review prioritizes supplements that meet four non-negotiable criteria : Uses Vitamin D3 (cholecalciferol) — not D2 Includes Vitam...
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Ivermectin and Fenbendazole in the Treatment of Psoriasis? A Case Series of 13 Patients (2026)

By Dr Frank Yap, MD -
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Abstract Psoriasis is a chronic autoimmune condition affecting approximately 7.5 million individuals in the United States, with significant economic, physical, and psychological burdens. This case series reports on 13 patients who experienced notable improvements in psoriasis symptoms following treatment with ivermectin and/or fenbendazole, antiparasitic agents repurposed for this indication. Cases were derived from self-reported testimonials shared on social media platforms. Treatment durations ranged from 3 days to 3 months, with dosages varying between 6 mg ivermectin twice daily and combinations with fenbendazole. Rapid resolution of skin lesions was observed in most cases, with some achieving near-complete clearance. While these anecdotal reports suggest potential therapeutic efficacy, controlled clinical trials are warranted to validate these findings and elucidate underlying mechanisms. Introduction Psoriasis is a chronic inflammatory disorder characterized by hyperproliferation...
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7 Best Cetylpyridinium Chloride Mouthwash Brands 2025

By Dr Frank Yap, MD -
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A meta-analysis of 3 studies (C19early 2025) concluded that CPC (CetylPyridinium Chloride) may significantly lower risk with  viral clearance . One study shows significant benefit. Meta analysis using the most serious outcome reported shows 83% [6‑97%] lower risk . Results are consistent with early treatment being more effective than late treatment. A study, published in Nature ( Takeda 2022 ) concluded that CPC (CetylPyridinium Chloride) may inhibit SARS-CoV-2 infection even at lower concentrations. Another team of international scientists has also demonstrated the usefulness of cetylpyridinium chloride-containing mouthwashes in inhibiting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and reducing the risk of viral transmission. The study is published in the Journal of Medical Microbiology (2022). A scientific review, published in the  Journal of Formosan Medical Association  (2022) also concluded that mouthwash containing CPC shows potential fo...
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17 Best Natural Ozempic Alternatives 2026 (Resource Guide)

By Dr Frank Yap, MD -
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Some of the best natural alternatives to Ozempic include berberine, a supplement that has shown potential in managing blood sugar and promoting weight loss, often referred to as “nature’s Ozempic” in wellness communities. High-fiber foods also play a crucial role by helping to control appetite and improve metabolic health. Other natural options include psyllium husk, which provides soluble fiber supporting satiety and digestive health, and curcumin, known for its anti-inflammatory properties, which may aid metabolic balance. Additionally, green tea extract, magnesium, protein-rich foods, and lifestyle factors like adequate sleep and stress reduction contribute to weight management.  However, none of these natural alternatives are as potent or fast-acting as Ozempic itself, and their effects can vary widely among individuals. It is important to consult a healthcare provider before starting any supplement regimen, especially for managing blood sugar or weight loss. The 2023 rep...
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Berberine and Natural GLP-1 Mimetics as Drug Alternatives (2026)

By Dr Frank Yap, MD -
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Introduction Prescription GLP-1 agonists like Ozempic and Mounjaro have revolutionized weight management and type 2 diabetes care. However, not everyone has access to these medications, and some prefer natural alternatives. Emerging research highlights berberine and certain natural GLP-1 mimetics as potential adjuncts or alternatives. These compounds may support blood sugar control, improve insulin sensitivity, and modestly aid natural weight loss — all through mechanisms similar to GLP-1 drugs. What Is Berberine? Berberine is a plant-based alkaloid found in barberry, goldenseal, Oregon grape, and other herbs . Mechanisms of Action: Activates AMPK , the body’s “metabolic master switch,” improving glucose uptake. Enhances insulin sensitivity . May increase GLP-1 secretion , helping regulate appetite and blood sugar. Clinical Evidence: Studies suggest berberine can reduce fasting blood sugar by 20–30 mg/dL . Modest weight loss of 5–7% over 12 weeks has been observed. Well-tolerated, w...
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Ozempic vs Wegovy vs Mounjaro vs Zepbound: Key Differences, Weight Loss Results & Which One Works Best in 2026

By Dr Frank Yap, MD -
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If you’re considering injectable medications for weight loss or type 2 diabetes , you’ve probably heard of Ozempic, Wegovy, Mounjaro, and Zepbound . These drugs are reshaping obesity and diabetes care, but with multiple options on the market, it can be confusing to know which is best for your goals. In this guide, we break down each medication, compare their weight-loss potential, diabetes benefits, and side effects — all in a simple, easy-to-digest format. What These Drugs Are & How They Work All four medications are injectables , but they differ in mechanism, dosage, and approval purpose : Ozempic & Wegovy: Both contain semaglutide , a GLP-1 receptor agonist. GLP-1 slows digestion, increases fullness, and helps regulate blood sugar. Mounjaro & Zepbound: Both contain tirzepatide , a dual GIP + GLP-1 receptor agonist. This dual action enhances insulin secretion and appetite suppression, often producing stronger weight loss. Key difference: Ozempic and Mounjaro are primari...
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Retatrutide vs Tirzepatide vs Semaglutide (Ozempic): GLP-1 Wars — Updated Review (2026)

By Dr Frank Yap, MD -
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The landscape of obesity treatment has evolved dramatically with the introduction of advanced medical therapeutics like retatrutide (RETA, LY3437943), tirzepatide (Mounjaro), and semaglutide (Ozempic). Glucagon-like peptide-1 receptor agonists and co-agonists, originally developed to manage type 2 diabetes, have shown remarkable efficacy in promoting weight loss, making them game-changers for obesity management. However, each drug has unique mechanisms, benefits, and potential applications, including emerging roles in cancer prevention. This article compares their mechanisms, clinical efficacy, broader health benefits, safety profiles, regulatory status, and practical considerations to help patients, clinicians, and informed readers understand how they stack up in 2026. Update: Are GLP-1s the first longevity drugs ? (Nature 2025) Credit: GoodRx Health Mechanism of Action Semaglutide : Semaglutide (Ozempic and Wegovy) is a glucagon-like peptide-1 receptor agonist (GLP-1 RA). It mimics ...
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Eating More Foods with Vitamin C Can Support Skin Thickness and Collagen Production — What the Science Really Says

By Dr Frank Yap, MD -
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New research suggests that getting enough vitamin C from foods may help support skin health by increasing collagen production and improving skin structure. While beauty brands invest billions in anti-aging creams, researchers in New Zealand have found something far simpler: Eating foods with vitamin C could boost the antiaging benefits your skin needs. ( ScienceDaily )  People who ate two kiwifruits daily—the equivalent of 250 micrograms of vitamin C—had thicker skin and accelerated skin regeneration after eight weeks. The discovery, from New Zealand’s University of Otago, reveals that vitamin C absorbed through the bloodstream travels into all layers of the skin, promoting thickness, regeneration, and a more youthful complexion. What the Study Found A 2025 published study in the Journal of Investigative Dermatology investigated how dietary vitamin C affects human skin: ( ScienceDaily ) Dietary intake increases skin levels: Vitamin C consumed through food enters the bloodstream a...
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Hydroxychloroquine, Azithromycin and Zinc: Dosage, Z Pak and Zelenko Protocol for COVID-19 (2023)

By Dr Frank Yap, MD -
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As of January 2023, there are  more than 2,000 studies  published related to the treatment and prevention of COVID-19. As of January 2023, there are more than 350 published evidence of hydroxychloroquine for COVID-19 ( c19hcq.org ). As of January 2023, there are 38 published evidence of zinc for COVID-19 ( c19early.org/z ). In 2020, Hydroxychloroquine was touted as the most controversial drug in the world. Is there any new evidence to confirm or to disprove previous evidence? Hydroxychloroquine, Zinc and Azithromycin are among the handful of COVID-19 treatments that are being studied as potential candidates that might influence the outcome in the prevention and management of COVID-19.  Who makes hydroxychloroquine? Hydroxychloroquine (generic or scientific name) comes in various brand names. Plaquenil is a brand name of hydroxychloroquine from Sanofi.  Who makes azitromycin? Azithromycin (scientific name) comes in various brand names as well. Zithromax (from Pfizer),...
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CAR-T vs CAR-NK Cell: The Cancer Cell Therapy Showdown (2026)

By Dr Frank Yap, MD -
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One of the most promising approaches in cellular therapies is immunotherapies using engineered T cells or natural killer (NK) cells expressing chimeric antigen receptors (CARs). Will CAR-NK cell therapies overshadow traditional CAR-T options for the treatment of some cancers?   Recently researchers have tried to modify natural killer (NK) cells with chimeric antigen receptors (CAR) to increase potential to bind and destroy cancer cells, known as NK cell therapy. Here we describe the differences between CAR T cell therapies and CAR NK cell therapies to consider when developing cancer treatments for patients. What is CAR-T? T cells are part of the adaptive immune system and are intended to generate a long lasting protective immune response. By engineering T cells with the Natural Killer Group 2D (NKG2D) receptor, they become NKG2D CAR T cell therapies. What is CAR-NK?  NK cells are a part of the innate immune system and are the first line of defense against foreign infections a...
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