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UK Clinical Trial Confirms SaNOtize’s Breakthrough Treatment for COVID-19

By Dr Frank Yap, MD -
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Patients with a self-administered nasal spray application found to have reduced SARS-CoV-2 log viral load by more than 95% in infected participants within 24 hours of treatment, and by more than 99% in 72 hoursTrial concluded that treatment accelerated clearance of SARS-CoV-2 by a factor of 16-fold versus a placebo Randomized, double-blind, placebo-controlled trial evaluated 79 confirmed cases of COVID-19, the majority heavily-infected with the UK variant No adverse events were recorded in the group Submission for Emergency Use in the UK and Canada for the treatment and prevention of COVID-19 is planned immediately VANCOUVER, British Columbia & SURREY, England--(BUSINESS WIRE)--Biotech company SaNOtize Research & Development Corp., (SaNOtize), Ashford and St Peter’s Hospitals NHS Foundation Trust in Surrey, UK, and Berkshire and Surrey Pathology Services, UK, today announced results of clinical trials indicating that SaNOtize’s Nitric Oxide Nasal Spray (NONS) represents a safe ...
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7 Best Cetylpyridinium Chloride Mouthwash Brands 2025

By Dr Frank Yap, MD -
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A meta-analysis of 3 studies (C19early 2025) concluded that CPC (CetylPyridinium Chloride) may significantly lower risk with  viral clearance . One study shows significant benefit. Meta analysis using the most serious outcome reported shows 83% [6‑97%] lower risk . Results are consistent with early treatment being more effective than late treatment. A study, published in Nature ( Takeda 2022 ) concluded that CPC (CetylPyridinium Chloride) may inhibit SARS-CoV-2 infection even at lower concentrations. Another team of international scientists has also demonstrated the usefulness of cetylpyridinium chloride-containing mouthwashes in inhibiting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and reducing the risk of viral transmission. The study is published in the Journal of Medical Microbiology (2022). A scientific review, published in the  Journal of Formosan Medical Association  (2022) also concluded that mouthwash containing CPC shows potential fo...
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Best Vitamin D3 + K2 Supplements in 2026: Doctor-Reviewed Picks for Bone, Heart & Immune Health

By Dr Frank Yap, MD -
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Vitamin D3 and Vitamin K2 are two of the most commonly deficient—and misunderstood—nutrients today. While Vitamin D improves calcium absorption, Vitamin K2 determines where that calcium actually goes . That’s why taking Vitamin D without K2 may be incomplete—and in some cases counterproductive. After reviewing ingredient quality, dosing accuracy, brand transparency, and real-world user feedback, the following are the best Vitamin D3 + K2 supplements available in 2026 . Most people in the United States consume less than recommended amounts of vitamin D . An analysis of data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 4.3 mcg in men, 3.8 mcg in women, and 5 mcg (200 IU) in children aged 2–19 years ( NHANES 2017 - 2018 ). Why Trust This Guide? This review prioritizes supplements that meet four non-negotiable criteria : Uses Vitamin D3 (cholecalciferol) — not D2 Includes Vitam...
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Quercetin and Bromelain for Allergies 2023

By Dr Frank Yap, MD -
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More than 50 million Americans who live with seasonal allergies. These symptoms tend to crop up with the onset of tree allergy season, followed by grass and weed season, notes Kevin McGrath, MD, an allergist in private practice in Wethersfield, Connecticut, and spokesperson for the American College of Allergy, Asthma, and Immunology. "The combination of trees, grasses, weeds, and molds makes for a difficult spring for most allergy patients and leads to sneezing, congestion, postnasal drip, sinus pain and pressure, watery eyes, and fatigue," he says. The good news is that there are a myriad of over the counter treatments out there that help ease the debilitating symptoms that accompany seasonal allergies.   Related: Best Nasal Sprays for Allergies What is Quercetin and Bromelain? Studies have shown bromelain combined with quercetin, produce greater anti-inflammatory benefits than either one used alone. Thus, the combination of bromelain and quer...
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Ozempic vs Wegovy vs Mounjaro vs Zepbound: Key Differences, Weight Loss Results & Which One Works Best in 2026

By Dr Frank Yap, MD -
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The era of GLP-1 weight loss drugs is no longer emerging—it’s already dominating modern medicine. In less than five years, medications like Ozempic, Wegovy, Mounjaro, and Zepbound have shifted obesity treatment from marginal success to clinically meaningful, double-digit weight loss backed by large-scale randomized trials . The numbers are not subtle. In pivotal studies, semaglutide (Wegovy) delivered ~15% average weight loss, while tirzepatide (Mounjaro/Zepbound) pushed results beyond 20%—approaching outcomes once only seen with bariatric surgery . At the same time, these drugs are showing cardiovascular risk reduction, improved glycemic control, and potential benefits across fatty liver disease, inflammation, and metabolic syndrome . Yet despite the hype, most comparisons online are superficial—and often misleading. These drugs are not interchangeable . They belong to different pharmacologic classes, target different hormone pathways, and produce meaningfully different outcomes in...
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Retatrutide vs Tirzepatide vs Semaglutide (Ozempic): GLP-1 Wars — Updated Review (2026)

By Dr Frank Yap, MD -
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The landscape of obesity treatment has evolved dramatically with the introduction of advanced medical therapeutics like retatrutide (RETA, LY3437943), tirzepatide (Mounjaro), and semaglutide (Ozempic) . Glucagon-like peptide-1 receptor agonists and co-agonists, originally developed to manage type 2 diabetes, have shown remarkable efficacy in promoting weight loss, making them game-changers for obesity management. However, each drug has unique mechanisms, benefits, and potential applications, including emerging roles in cancer prevention. This article compares their mechanisms, clinical efficacy, broader health benefits, safety profiles, regulatory status, and practical considerations to help patients, clinicians, and informed readers understand how they stack up in 2026. Update: Are GLP-1s the first longevity drugs ? (Nature 2025) Credit: GoodRx Health Mechanism of Action Semaglutide : Semaglutide (Ozempic and Wegovy) is a glucagon-like peptide-1 receptor agonist (GLP-1 RA). It mimics...
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How to Stimulate and Activate Stem Cells Naturally (2026 Edition)

By Dr Frank Yap, MD -
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What’s exciting about stem cells is that they are already in your body and ready to help with repair and healing. You can activate them naturally to improve your health. These strategies are not as therapeutic or powerful as stem cell therapy but they are very helpful for the body’s healing process. William W. Li MD writes in his book “Eat to Beat Disease,” “Your immune cells are regenerated every seven days, so if your stem cells disappeared, you’d likely die of an infection soon after.” However, you can increase your stem cells by certain lifestyle and nutritional factors.  What are stem cells? Stem cells  are a type of cell that has the potential to develop into different cell types in the body. Because of this, these types of cells can serve as a repair system and theoretically divide without limit to replenish other cells for as long as you are alive. When a stem cell divides, each "daughter" cell has the potential to either remain a stem cell or be...
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Chlormequat: Breakfast Cereals Scrutinized for Pesticide That May Harm Reproduction

By Dr Frank Yap, MD -
Imagine starting your day with a bowl of cereal that could be silently affecting your family’s health. Recent studies show that chlormequat, a pesticide linked to reproductive issues, has been found in popular breakfast cereals like Quaker Oats and Cheerios. As this substance infiltrates the American food supply, the potential risks to our health and future generations loom larger, raising urgent questions about the safety of our everyday food choices. In a study published in the Journal of Exposure Science & Environmental Epidemiology on Feb. 15, 2024, researchers revealed alarming findings regarding the prevalence of chlormequat. Chlormequat was detected in the urine of 4 out of 5 people or 80 percent of Americans tested. Additionally, 92 percent of oat-based foods tested contained chlormequat, including Quaker Oats and Cheerios. This study—the first to report urinary chlormequat measurements in adults living in the United States—highlights the possible widespread presence of c...
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Ivermectin and Fenbendazole in the Treatment of Psoriasis? A Case Series of 13 Patients (2026)

By Dr Frank Yap, MD -
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Abstract Psoriasis is a chronic autoimmune condition affecting approximately 7.5 million individuals in the United States, with significant economic, physical, and psychological burdens. This case series reports on 13 patients who experienced notable improvements in psoriasis symptoms following treatment with ivermectin and/or fenbendazole, antiparasitic agents repurposed for this indication. Cases were derived from self-reported testimonials shared on social media platforms. Treatment durations ranged from 3 days to 3 months, with dosages varying between 6 mg ivermectin twice daily and combinations with fenbendazole. Rapid resolution of skin lesions was observed in most cases, with some achieving near-complete clearance. While these anecdotal reports suggest potential therapeutic efficacy, controlled clinical trials are warranted to validate these findings and elucidate underlying mechanisms. Introduction Psoriasis is a chronic inflammatory disorder characterized by hyperproliferation...
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9 Best Calcium, Magnesium, Vitamin D3 and K2 Supplements 2025

By Dr Frank Yap, MD -
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Calcium, magnesium, vitamin D and Vitamin K2 are vitamin and minerals that are vital to several bodily processes. Though they occur naturally in a variety of foods, many people take supplements to help increase their intake. Benefits and uses 1. May support bone health Calcium is the main mineral in your bones, which hold more than 99% of your body’s calcium stores. Your body is constantly regenerating its bone tissue, so it’s important to consume an adequate amount of this mineral daily ( bones.nih.gov ). Magnesium plays a key role in converting vitamin D into its active form, which aids calcium absorption ( Trusted Source ). Therefore, you can minimize your vitamin D requirement by making sure you’re also getting enough magnesium. Research has confirmed higher magnesium intake helps reduce your risk of vitamin D deficiency by activating more of it.  A  groundbreaking 2017 review  compiled over 80 studies that show vitamin D3 and K2 together might be greater than...
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