Quercetin and Bromelain Benefits for Men 2023
What Is Quercetin?
Quercetin is an antioxidant that belongs to a class of water-soluble plant substances called flavonoids, which are present in certain fruits and vegetables. According to an article in Current Research in Nutrition and Food Science, the bioavailability of quercetin absorbed by your body varies, depending on the source where you get it, as well as your individual body’s metabolism of it. Sugar and dietary fat and fiber also affect it.
While the best way to get quercetin is through your diet, it also is available in supplement form, as pills or capsules. Sometimes, quercetin in supplement form is packaged with bromelain, an enzyme found in pineapples, because both have anti-inflammatory properties (Quercetin & Bromelain for inflammation). Most dietary supplements contain a chemical compound, aglycone, which is the free form of quercetin.
When looking for and using quercetin supplements, it’s important to maintain a nutritious, balanced diet with fiber and healthy fats in it, as research shows that accumulation of quercetin in the body is dependent on “factors such as glucose moieties, solubility, human factor, vitamin C status and food matrix.”
Specifically, research also says that quercetin supplementation is best achieved when consumed with a fat-enriched diet.
There are foods high in quercetin that you can add to your diet. Arguably, red onions are some of the most potent sources of quercetin; one study found that absorption of onion-derived quercetin was 52% compared to only 24% in supplement form. In fact, onions can give you three times the amount of quercetin than you’d get from apples. Other food sources that are high in quercetin include:
- Organically grown apples, grapes and tomatoes
- Dark cherries and dark berries like blueberries, blackberries and bilberries (eaten in moderation)
- Cocoa, unsweetened
- Hot green chili peppers
- Lingonberries
Benefits of Quercetin
Quercetin has been linked to the following health benefits:- Possessing anti-inflammatory, antioxidant properties that can help combat certain diseases. One study found that 500 mg of quercetin a day could improve symptoms of rheumatoid arthritis.
- Helping prevent cancer cell growth from breast, colon, prostate, endometrial and lung.
- Counteracting allergic reactions and helping with immune responses.
- Helping to prevent osteoporosis
- Addressing cognitive decline, including Alzheimer’s and dementia.
- Assisting in control of blood pressure. A study in 2002 found that quercetin can have vasodilator effects.
- Potentially helping to lower blood sugar levels. One study found that dosages of 500 mg per day “significantly reduced” fasting glucose levels.
Related: Best Quercetin Supplement 2020
What is Bromelain?
Bromelain, or pineapple extract, is a compound made up of proteases normally found in pineapples. Although it is widely known for its ability to aid in digestion and protein breakdown, its use far transcends these functions and can actually offer a lot more. The good news is that it's available in the market as a supplement and as an aid for disease treatments.The history of bromelain is heavily linked to pineapple because it is the only known major source for this group of enzymes. First discovered in 1891 by chemist Vicente Marcano and then subsequently elaborated by Russell Henry Chittenden, another chemist, bromelain was first called "bromelin," and described as the "proteolytic ferment of pineapple juice."
Its first primary source was the pineapple fruit, before it was discovered that the mature pineapple stem had much more concentrated bromelain content.
Through the years after its discovery, the production of bromelain has broadened. Its commercialization has led manufacturers into developing faster extraction techniques for large-scale production and purification. Today, bromelain supplements are used for numerous health approaches.
These uses have been observed to be dependent on the time when it is taken. For example, if taken after a meal, bromelain may help promote better digestion and absorption, but when taken on an empty stomach, it can help alleviate inflammation.(Daily Mail)
Benefits of Bromelain
As a protease enzyme, the primary benefit bromelain has is improving protein absorption. However, bromelain has been widely used to promote healing and assist in the treatment of numerous diseases. For example, if you're suffering from chronic inflammation or from sports injuries, consider taking bromelain supplements to help your body recover. Other bromelain benefits that you'll get from this supplement include:• Reduces inflammation and swelling — Bromelain may help alleviate symptoms of osteoarthritis and rheumatism. It's also used to help in sprain and strain recovery by reducing swelling and promote tissue healing. For people who are currently on arthritis medications, consider switching to bromelain for a more natural alternative.
• Improves immune function — Studies show that bromelain promotes a healthy immune system by regulating numerous inflammatory proteins during periods of cellular stress.
• Speeds up wound healing — The use of bromelain post-surgery has been observed to promote soft-tissue healing and reduce bruising. Patients who took bromelain also had shorter wound healing time compared to patients who did not.
• Relieves sinusitis symptoms — Sinusitis refers to the inflammation of the inner lining of the sinuses, which is usually caused by infections, nasal problems or allergies. Bromelain is a known supplement for relieving sinusitis symptoms. Together with quercetin, bromelain can help alleviate sinus inflammation, with quercetin functioning as an antihistamine.
• Promotes blood flow — Bromelain helps in promoting healthy blood flow by reducing platelet aggregation in the arteries and lowering the chances of clots forming. This may lower your risk of developing atherosclerosis and other cardiovascular diseases.
There are also claims that bromelain can help induce menstruation by softening the uterine lining. The increased blood flow also supposedly helps in the prevention of menstrual cramps.
Because of the impressive components of bromelain, it's not surprising that it's been utilized in treating or reducing the severity of disease symptoms. While it is usually prescribed or recommended for patients who have undergone surgery or people suffering from chronic sinusitis, bromelain can also be used in other ways. These include:
• Topical application for burns — Studies suggest that bromelain can help remove dead skin cells from third degree burns and assist in burn healing in first and second degree burns. For severe burns, do not apply any bromelain ointment without a physician's supervision.
• Indigestion and heartburn — Taking bromelain has been known to assist in easing indigestion and bloating, especially when taken with other supplemental enzymes.
• Soothing balm for insect bites and stings — Applying bromelain directly to insect bites and stings may lessen inflammation and discomfort.
• Meat tenderizer — Pineapple has been used in cooking to soften meats. Today, bromelain is sold in powder form as a meat tenderizer and is usually combined with papain, an enzyme found in the papaya plant. In fact, bromelain is such a strong meat tenderizer that chefs and cooks claim it can turn meat into mush if left marinated for longer periods of time.
Quercetin and Bromelain Side Effects
According to WebMD, quercetin is POSSIBLY SAFE for most people when taken by mouth on a short-term basis. Quercetin has been safely used in amounts up to 500 mg twice daily for 12 weeks. It is not known if long-term use or higher doses are safe.When taken by mouth, quercetin could cause headache, stomach upset and tingling of the arms and legs. Very high doses might cause kidney damage.
Those who are taking blood thinners or have concern about the adverse effects of bromelain, should consider quercetin supplements that do not contain bromelain.
Quercetin intake should be avoided by pregnant and lactating women. People with kidney problems should also avoid its consumption.
Very high doses of quercetin (above 1 g), were found to have adverse effects on kidney functioning.
Review
Very high doses of quercetin (above 1 g), were found to have adverse effects on kidney functioning.
Quercetin and Bromelain Supplements for Men on Amazon
1. Amazing Formulas - Quercetin 500 Mg
1. Amazing Formulas - Quercetin 500 Mg
Amazon Best Sellers: #1 Best Seller in Flavonoid Vitamin Supplements. 4.7 out of 5 overall rating with more than 12,000 customer reviews.
- Quercetin is a flavonoid (plant pigment) naturally found in fruits and vegetables. It is found in many foods, such as red wine, onions, green tea, apples, berries etc. It known for its Anti-oxidant and Anti-Inflammatory Properties. Amazing Nutrition Quercetin 500 Mg is offered in Veggie Capsule to suit most diet preferences
- Anti-oxidant properties of Qurecetine Supports Healthy Ageing, Cardiovascular Health, and Immune Health. It helps to reduce the damage and irritation caused by free radicals
- Anti-Inflammatory properties of Quercetin helps to lower the release of histamines, a compound that is released by cells in response to allergic and inflammatory reactions. Subsequently helping to lower pains and discomfort related to Inflammation.
- All Amazing Nutrition products are manufactured in accordance with Good Manufacturing Practices (GMP), among the highest standards in the world.
I've been sick twice in the past two months, one a mild cold, the other quite severe, DID NOT GET TESTED so can not attest to Covid 19. Anyway, once I got sick, I took 1000mg of Quercetin, combined with 200mg of Zinc Picolinate - ANECDOTAL EVIDENCE: I was free and clear of symptoms in the range of 6 to 10 hours, save for a lingering itch in my sinuses, which was gone after a good nights sleep. Symptoms did not return in either case. This was ONE DOSE.
Amazon Best Sellers: #1 Best Seller in Flavonoid Vitamin Supplements. 4.7 out of 5 overall rating with more than 12,000 customer reviews.
- Anti-oxidant properties of Qurecetine Supports Healthy Ageing, Cardiovascular Health, and Immune Health. It helps to reduce the damage and irritation caused by free radicals
- Anti-Inflammatory properties of Quercetin helps to lower the release of histamines, a compound that is released by cells in response to allergic and inflammatory reactions. Subsequently helping to lower pains and discomfort related to Inflammation.
- All Amazing Nutrition products are manufactured in accordance with Good Manufacturing Practices (GMP), among the highest standards in the world.
2. MoxyVites Quercetin 500mg with Bromelain Supplement
- Bioactive Phytosome Complex
- Pure Organic Whole Food Seasonal Support
- Healthy Inflammatory Response
-120 Caps
- Plant Based
- Made in USA
- Quercetin, Phytosome, Bromelain
- All Natural, Organic, Vegan, Vegetarian, Gluten Free, Non GMO, No Artificial or Synthetic Ingredients
- GMP certified facility, THIRD PARTY TESTED!
- IMPROVED ORAL ABSORPTION BY 20X
> Regular quercetin has poor solubility and low oral absorption. Our technology binds quercetin with a glucose bond & incorporation of phospholipids into standardized extracts improving the absorption and bioavailability by 20X. If you settle for regular quercetin your body may only absorb 20% with minimal to no benefit.
- BIOACTIVE FORM OF QUERCETIN
> Our complex delivery system utilizes phytosome technology in which phytoconstituents react with phospholipids for better and improved bioavailability. Our quercetin is one of the most effective on the market today!
- NATURAL SEASONAL RELIEF
> Nutritional support from carefully selected WHOLE FOODS containing the highest amounts of quercetin with powerful antioxidants. Backed by science to provide all year support for individuals with allergies
- POWERFUL BENEFITS
> Powerful antioxidant, healthy inflammatory responses, boost the immune system, reduce histamines and skin irritations, supports cardiovascular & cellular health.
- PHARMACEUTICAL GRADE:
> Highly bioavailable & Potent 500mg serving with 120 capsules in a bottle.
Ratings
4.9 out of 5 - 89 global ratings on Amazon
Review
This is the best quercetin I found on the market! It was a revelation to me to discover that regular quercetin is difficult for the body to absorb. After doing my research I discovered that quercetin phytosome has much greater absorption and is therefore more effective. I have been taking this for over a month and my allergy symptoms have been reduced tremendously. In addition, this company added specific Whole Foods that contain the highest amount of added quercetin for additional quercetin benefits. Besides allergies I also take this for it’s high anti oxidants and many other health benefits. I love this brand and I will continue to buy their products.
Buy on Amazon
2. MoxyVites Quercetin 500mg with Bromelain Supplement
- Bioactive Phytosome Complex
- Pure Organic Whole Food Seasonal Support
- Healthy Inflammatory Response
-120 Caps
- Plant Based
- Made in USA
- Quercetin, Phytosome, Bromelain
- All Natural, Organic, Vegan, Vegetarian, Gluten Free, Non GMO, No Artificial or Synthetic Ingredients
- GMP certified facility, THIRD PARTY TESTED!
- IMPROVED ORAL ABSORPTION BY 20X
> Regular quercetin has poor solubility and low oral absorption. Our technology binds quercetin with a glucose bond & incorporation of phospholipids into standardized extracts improving the absorption and bioavailability by 20X. If you settle for regular quercetin your body may only absorb 20% with minimal to no benefit.
- BIOACTIVE FORM OF QUERCETIN
> Our complex delivery system utilizes phytosome technology in which phytoconstituents react with phospholipids for better and improved bioavailability. Our quercetin is one of the most effective on the market today!
- NATURAL SEASONAL RELIEF
> Nutritional support from carefully selected WHOLE FOODS containing the highest amounts of quercetin with powerful antioxidants. Backed by science to provide all year support for individuals with allergies
- POWERFUL BENEFITS
> Powerful antioxidant, healthy inflammatory responses, boost the immune system, reduce histamines and skin irritations, supports cardiovascular & cellular health.
- PHARMACEUTICAL GRADE:
> Highly bioavailable & Potent 500mg serving with 120 capsules in a bottle.
Ratings
4.9 out of 5 - 89 global ratings on Amazon
Review
This is the best quercetin I found on the market! It was a revelation to me to discover that regular quercetin is difficult for the body to absorb. After doing my research I discovered that quercetin phytosome has much greater absorption and is therefore more effective. I have been taking this for over a month and my allergy symptoms have been reduced tremendously. In addition, this company added specific Whole Foods that contain the highest amount of added quercetin for additional quercetin benefits. Besides allergies I also take this for it’s high anti oxidants and many other health benefits. I love this brand and I will continue to buy their products.
Buy on Amazon
3. Forest Leaf Quercetin, Bromelain, Stinging Nettle, Vitamin C
Uniquely formulated using a blend of quercetin and bromelain, this supplement from ForestLeaf may help with sinus relief, allergies, cardiovascular and respiratory health.
- Advanced Sinus and Allergy Supplement - Natural Vegetable Capsules - Non GMO, Dairy, Gluten, Egg and Nut Free - Every pill contains stinging nettle leaf extract. - All of its products and pills are tested for maximum absorption. - 45 servings per bottle, 200mg of vitamin C per serving.
IngredientsVitamin C 200mg, Quercetin 500mg, Stinging Nettle Leaf 500mg, Bromelain 150mg, Vegetable Cellulose (capsule), Microcrystalline Cellulose, Magnesium Stearate and Silicon Dioxide
I have year round allergies and lately what I had been taking wasn't working and my eyes were always running. It was extremely annoying and frustrating to be crying from one eye all day. I read the reviews and decided to try this. I've been taking them twice a day since March 1st and I stopped crying the first day. I love these natural pills. They work!!!!
4.6 out of 5 - 2,342 global ratings
3. Forest Leaf Quercetin, Bromelain, Stinging Nettle, Vitamin C
Uniquely formulated using a blend of quercetin and bromelain, this supplement from ForestLeaf may help with sinus relief, allergies, cardiovascular and respiratory health.
- Advanced Sinus and Allergy Supplement
- Natural Vegetable Capsules
- Non GMO, Dairy, Gluten, Egg and Nut Free
- All of its products and pills are tested for maximum absorption.
- 45 servings per bottle, 200mg of vitamin C per serving.
4. Thorne Research Quercenase
Quercenase is a combination of quercetin phytosome and bromelain. Quercetin phytosome is a new food-grade lecithin-based formulation of quercetin, was developed to overcome the low bioavailability hurdle of quercetin. Phytosome complexes are created by a patented process that binds a botanical extract to a phospholipid (phosphatidylcholine), which are key components of every cell membrane.
- Each capsule contains 250 mg of quercetin phytosome and 100 mg of bromelain.
- BestReviews.com: Pricier than many similar products on the market
- Amazon Best Sellers: #11 Best Seller in Flavonoid Vitamin Supplements
- Our Take: If you are looking to buy from a reputable brand, this would be your choice.
Review
I have histamine intolerance and had spent many years taking prescription and OTC drugs. I wanted to get away from drugs and my functional medicine doctor recommended d-hist. It worked on my allergies but I would get migraines if I took it too often. I think it was the nettles. Anyway, I also didn't like that they used magnesium stearate. I bought this and it works just as well as my Claritin did. I get relief from runny nose and sneezing as well as itchy skin. I will sometimes add some extra bromelain but I am very happy. Thorne products are often more expensive but they use better ingredients and omit questionable ingredients that make production cheaper
5. MT Angel Vitamins - Quercetin Zinc Immune Support Supplement
- Contains Vitamins C & D3, Stinging Nettle Root and Bromelain
- Immune Boost to Fight Flare-Ups, Improve Respiratory Health & Energy
- Quercetin with vitamin C and zinc are proven not only to provide immune support but also to improve metabolism, circulatory supporty, and cognitive clarity.
- By fostering cellular functioning, these antioxidants enhance respiratory health and energy levels so you can enjoy activities.
- GMP-certified supplements
- Gluten-free, no GMO and vegetarian, your quercetin supplement defends systems with organic elements
Ratings
4.7 out of 5 - 1,105 global ratings
Reviews
My husband read the Swiss protocal for Covid 19 preventative and this has it all. So far so good no problems. No bad taste easy to swallow, our 12yr old son even has no priblem.
6. Whole Food Quercetin Plus
- Quercetin with Bromelain-Zinc-Vitamin C-Ginger-Bioflavonoids
- Organic Whole Foods
- Immune, Cardiovascular & Respiratory System Support
- Natural Antioxidant
- Vegan, Non-GMO
- 180 Caps, 90 servings
-Immunity supporting properties, improves healthy seasonal immune system function, and reduces inflammation. - May help improve your daily health by aiding exercise performance, improving digestion, helping respiratory health, give your immune system the boost it needs, and enhance cognitive function.
- FREE from GMO, Alcohol, Preservatives, Soy Lecithin, Gelatin, Dairy, Sugar, Gluten, Shellfish, Nuts, Wheat, Stearates, Silicon Dioxide, fillers, Artificial Ingredients.
- Manufactured in the USA. Made in a GMP-certified facility in the USA. Third-party tested.
Nutrients
Quercetin 500 mg + 175 mg of Organic Whole Food Quercetin Blend(4 Organic Whole Food Quercetin source ingredients) + 15 mg of Zinc Picolinate + 200 mg of Bromelain from Pineapple + 100 mg of Organic Ginger Root + 125 mg of Vitamin C from Organic Acerola Cherries + 100 mg of Citrus Bioflavonoids from Organic Orange & Organic Lemon
Review
I am able to do much more before having to take a rest break. Also I have notice a very marked drop in BG an hour after taking. Definitely recommend.
Buy on Amazon
- Contains Vitamins C & D3, Stinging Nettle Root and Bromelain
- Immune Boost to Fight Flare-Ups, Improve Respiratory Health & Energy
- Quercetin with vitamin C and zinc are proven not only to provide immune support but also to improve metabolism, circulatory supporty, and cognitive clarity.
- By fostering cellular functioning, these antioxidants enhance respiratory health and energy levels so you can enjoy activities.
- GMP-certified supplements
- Gluten-free, no GMO and vegetarian, your quercetin supplement defends systems with organic elements
Ratings
4.7 out of 5 - 1,105 global ratings
Reviews
My husband read the Swiss protocal for Covid 19 preventative and this has it all. So far so good no problems. No bad taste easy to swallow, our 12yr old son even has no priblem.
6. Whole Food Quercetin Plus
- Organic Whole Foods
- Immune, Cardiovascular & Respiratory System Support
- Natural Antioxidant
- Vegan, Non-GMO
- 180 Caps, 90 servings
-Immunity supporting properties, improves healthy seasonal immune system function, and reduces inflammation.
- May help improve your daily health by aiding exercise performance, improving digestion, helping respiratory health, give your immune system the boost it needs, and enhance cognitive function.
- FREE from GMO, Alcohol, Preservatives, Soy Lecithin, Gelatin, Dairy, Sugar, Gluten, Shellfish, Nuts, Wheat, Stearates, Silicon Dioxide, fillers, Artificial Ingredients.
- Manufactured in the USA. Made in a GMP-certified facility in the USA. Third-party tested.
Nutrients
Quercetin 500 mg + 175 mg of Organic Whole Food Quercetin Blend(4 Organic Whole Food Quercetin source ingredients) + 15 mg of Zinc Picolinate + 200 mg of Bromelain from Pineapple + 100 mg of Organic Ginger Root + 125 mg of Vitamin C from Organic Acerola Cherries + 100 mg of Citrus Bioflavonoids from Organic Orange & Organic Lemon
Review
I am able to do much more before having to take a rest break. Also I have notice a very marked drop in BG an hour after taking. Definitely recommend.
Buy on Amazon
- FREE from GMO, Alcohol, Preservatives, Soy Lecithin, Gelatin, Dairy, Sugar, Gluten, Shellfish, Nuts, Wheat, Stearates, Silicon Dioxide, fillers, Artificial Ingredients.
- Manufactured in the USA. Made in a GMP-certified facility in the USA. Third-party tested.
Nutrients
Quercetin 500 mg + 175 mg of Organic Whole Food Quercetin Blend(4 Organic Whole Food Quercetin source ingredients) + 15 mg of Zinc Picolinate + 200 mg of Bromelain from Pineapple + 100 mg of Organic Ginger Root + 125 mg of Vitamin C from Organic Acerola Cherries + 100 mg of Citrus Bioflavonoids from Organic Orange & Organic Lemon
Review
I am able to do much more before having to take a rest break. Also I have notice a very marked drop in BG an hour after taking. Definitely recommend.
Buy on Amazon
Related item: Fingertip Pulse Oximeter (Amazon)
Precaution: Always see your doctor before taking these supplements. Be aware that most of the dosages are above the recommended dietary allowance (RDA) and therefore such dosages should not be maintained on a long term basis.
Disclaimer: The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of third party sites. If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content. Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that supplements are not 100% protective or curative against COVID-19.
FAQs
1. Quercetin and Vitamin C for COVID-19?
There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immuno-modulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy.
Further, quercetin has poor bioavailability and isn’t absorbed very well, however taking it with vitamin C and bromelain can increase the amount of quercetin your body absorbs.
For prevention, the Front Line COVID-19 Critical Care Working Group (FLCCC) recommends (updated April 26, 2021):- Vitamin D3: 1000–3000 IU/day. Note RDA (Recommended Daily Allowance) is 800–1000 IU/day. The safe upper-dose daily limit is likely < 4000 IU/day. Vitamin D deficiency has been associated with an increased risk of acquiring COVID-19 and from dying from the disease. Vitamin D supplementation may therefore prove to be an effective and cheap intervention to lessen the impact of this disease, particularly in vulnerable populations, i.e. the elderly and obese. (Amazon)
- Vitamin C: 500 - 1,000 mg BID (twice daily)
- Quercetin: 250 mg daily. It is likely that vitamin C and quercetin have synergistic prophylactic benefit. Quercetin should be used with caution in patients with hypothyroidism and TSH levels should be monitored. (Amazon)
- Melatonin: 6 mg before bedtime (causes drowsiness). (Amazon)
- Zinc: 30 - 40 mg/day (elemental zinc). Zinc lozenges are preferred. (Amazon)
- Ivermectin prophylaxis dosage:
- prevention in high-risk individuals (> 60 years with co-morbidities, morbid obesity, long term care facilities, etc): 0.2 mg/kg per dose (take with or after meals) — one dose today, repeat after 48 hours, then one dose weekly. (also see ClinTrials.gov NCT04425850).
- Post COVID-19 exposure prevention: 0.2 mg/kg per dose (take with or after meals) — one dose today, repeat after 48 hours.
Precautionary Note: Ivermectin has a number of potentially serious drug-drug interactions. Please check for potential drug interaction at Ivermectin Drug Interactions - Drugs.com. The most important drug interactions occur with cyclosporin, tacrolimus, anti-retroviral drugs, and certain anti-fungal drugs.
Due to the possible drug interaction between quercetin and ivermectin (may increase ivermectin levels), these drugs should not be taken simultaneously (i.e. should be staggered morning and night).
Ivermectin is also lipophilic and therefore, bioavailability is maximised on a full stomach; or best to be taken with meal.
Related item: Fingertip Pulse Oximeter (Amazon)
Precaution: Always see your doctor before taking these supplements. Be aware that most of the dosages are above the recommended dietary allowance (RDA) and therefore such dosages should not be maintained on a long term basis.
Disclaimer: The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of third party sites. If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content. Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that supplements are not 100% protective or curative against COVID-19.
FAQs
1. Quercetin and Vitamin C for COVID-19?
There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immuno-modulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy.
For prevention, the Front Line COVID-19 Critical Care Working Group (FLCCC) recommends (updated April 26, 2021):
- Vitamin D3: 1000–3000 IU/day. Note RDA (Recommended Daily Allowance) is 800–1000 IU/day. The safe upper-dose daily limit is likely < 4000 IU/day. Vitamin D deficiency has been associated with an increased risk of acquiring COVID-19 and from dying from the disease. Vitamin D supplementation may therefore prove to be an effective and cheap intervention to lessen the impact of this disease, particularly in vulnerable populations, i.e. the elderly and obese. (Amazon)
- Vitamin C: 500 - 1,000 mg BID (twice daily)
- Quercetin: 250 mg daily. It is likely that vitamin C and quercetin have synergistic prophylactic benefit. Quercetin should be used with caution in patients with hypothyroidism and TSH levels should be monitored. (Amazon)
- Melatonin: 6 mg before bedtime (causes drowsiness). (Amazon)
- Zinc: 30 - 40 mg/day (elemental zinc). Zinc lozenges are preferred. (Amazon)
- Ivermectin prophylaxis dosage:
- prevention in high-risk individuals (> 60 years with co-morbidities, morbid obesity, long term care facilities, etc): 0.2 mg/kg per dose (take with or after meals) — one dose today, repeat after 48 hours, then one dose weekly. (also see ClinTrials.gov NCT04425850).
- Post COVID-19 exposure prevention: 0.2 mg/kg per dose (take with or after meals) — one dose today, repeat after 48 hours.
Precautionary Note: Ivermectin has a number of potentially serious drug-drug interactions. Please check for potential drug interaction at Ivermectin Drug Interactions - Drugs.com. The most important drug interactions occur with cyclosporin, tacrolimus, anti-retroviral drugs, and certain anti-fungal drugs.
Due to the possible drug interaction between quercetin and ivermectin (may increase ivermectin levels), these drugs should not be taken simultaneously (i.e. should be staggered morning and night).
Ivermectin is also lipophilic and therefore, bioavailability is maximised on a full stomach; or best to be taken with meal.
Related: List of Doctors that will prescribe Ivermectin
For early outpatient protocol (COVID-19 positive), the Front Line COVID-19 Critical Care Working Group, FLCCC recommends (Apr 26, 2021 version):- Vitamin D3 — 4000 IU/day. (Amazon)
- Vitamin C: 500 - 1,000 mg BID (twice daily) (Amazon)
- Quercetin: 250 mg twice a day. (Amazon)
- Melatonin: 10 mg before bedtime (causes drowsiness). (Amazon)
- Zinc: 100 mg/day. Zinc lozenges are preferred. (Amazon)
- Ivermectin: 0.2–0.4 mg/kg per dose (take with or after meals) — one dose daily, take for 5 days or until recovered. (Find a Doctor). Use upper dose range if: 1) in regions with more aggressive variants; 2) treatment started on or after day 5 of symptoms or in pulmonary phase; or 3) multiple comorbidities/risk factors.
- Fluvoxamine: 50 mg twice daily for 10–14 days. Add to ivermectin if: 1) minimal response after 2 days of ivermectin; 2) in regions with more aggressive variants; 3) treatment started on or after day 5 of symptoms or in pulmonary phase; or 4) numerous co-morbidities/risk factors. Avoid if patient is already on an SSRI (selective serotonin reuptake inhibitor).
- Nasopharyngeal Sanitation: Steamed essential oil inhalation 3 times a day (i.e. vapo-rub) and/or chlorhexidine/benzydamine mouthwash gargles and Betadine nasal spray 2–3 times a day.
- Aspirin: 325 m/day unless contraindicated.
- Pulse Oximeter: FLCCC also recommend monitoring your oxygen saturation with a pulse oximeter and to go to the hospital if you get below 94%.
The medical evidence to support each drug and nutrient can be found under “Medical Evidence” on the FLCCC’s website.
2. Quercetin, Zinc and Vitamin C - Dr Zelenko's Protocol for COVID-19
According to Dr. Zelenko, the best over the counter substitute or natural alternative to hydroxychloroquine is quercetin.
When hydroxychloroquine is not available, Dr. Zelenko recommends the following OTC treatment in the early stages of COVID-19 and quercetin as a natural alternative to hydroxychloroquine. He recommends this treatment immediately after you are tested positive and with symptoms.- Quercetin 500 mg – 3 times a day for 7 days.
- Zinc 50 mg (elemental zinc) – 1 a day for 7 days.
- Z-pack/Zithromax 500 mg or Azythromicin – 1 day for 5 days.
- Vitamin C 1000 mg – 1 a day for 7 days.
As a prevention treatment, Dr. Zelenko recommends the OTC alternative to hydroxychloroquine above without the antibiotic (azythromicin). His prophylaxis for COVID-19 is the following:
- Quercetin 500 mg / once a day.
- Zinc 25 mg (elemental zinc) / once a day.
- Vitamin C 1000 mg / once a day.
For early outpatient protocol (COVID-19 positive), the Front Line COVID-19 Critical Care Working Group, FLCCC recommends (Apr 26, 2021 version):
- Vitamin D3 — 4000 IU/day. (Amazon)
- Vitamin C: 500 - 1,000 mg BID (twice daily) (Amazon)
- Quercetin: 250 mg twice a day. (Amazon)
- Melatonin: 10 mg before bedtime (causes drowsiness). (Amazon)
- Zinc: 100 mg/day. Zinc lozenges are preferred. (Amazon)
- Ivermectin: 0.2–0.4 mg/kg per dose (take with or after meals) — one dose daily, take for 5 days or until recovered. (Find a Doctor). Use upper dose range if: 1) in regions with more aggressive variants; 2) treatment started on or after day 5 of symptoms or in pulmonary phase; or 3) multiple comorbidities/risk factors.
- Fluvoxamine: 50 mg twice daily for 10–14 days. Add to ivermectin if: 1) minimal response after 2 days of ivermectin; 2) in regions with more aggressive variants; 3) treatment started on or after day 5 of symptoms or in pulmonary phase; or 4) numerous co-morbidities/risk factors. Avoid if patient is already on an SSRI (selective serotonin reuptake inhibitor).
- Nasopharyngeal Sanitation: Steamed essential oil inhalation 3 times a day (i.e. vapo-rub) and/or chlorhexidine/benzydamine mouthwash gargles and Betadine nasal spray 2–3 times a day.
- Aspirin: 325 m/day unless contraindicated.
- Pulse Oximeter: FLCCC also recommend monitoring your oxygen saturation with a pulse oximeter and to go to the hospital if you get below 94%.
2. Quercetin, Zinc and Vitamin C - Dr Zelenko's Protocol for COVID-19
According to Dr. Zelenko, the best over the counter substitute or natural alternative to hydroxychloroquine is quercetin.
When hydroxychloroquine is not available, Dr. Zelenko recommends the following OTC treatment in the early stages of COVID-19 and quercetin as a natural alternative to hydroxychloroquine. He recommends this treatment immediately after you are tested positive and with symptoms.
- Quercetin 500 mg – 3 times a day for 7 days.
- Zinc 50 mg (elemental zinc) – 1 a day for 7 days.
- Z-pack/Zithromax 500 mg or Azythromicin – 1 day for 5 days.
- Vitamin C 1000 mg – 1 a day for 7 days.
- Quercetin 500 mg / once a day.
- Zinc 25 mg (elemental zinc) / once a day.
- Vitamin C 1000 mg / once a day.
3. Quercetin with Bromelain for Inflammation
Studies have shown that systemic enzymes for inflammation (like bromelain) combined with quercetin, produce greater anti-inflammatory benefits than either one used alone. Thus, the combination of bromelain and quercetin is ideal for effectively inhibiting the inflammatory response in both acute and chronic inflammatory conditions.
Since bromelain and quercetin are recommended to be taken together for maximum anti-inflammatory benefit, formulas that contain both ingredients are ideal. This also simplifies the dosing schedule and reduces the total number of capsules needed to be taken throughout the day.
Studies have shown that systemic enzymes for inflammation (like bromelain) combined with quercetin, produce greater anti-inflammatory benefits than either one used alone. Thus, the combination of bromelain and quercetin is ideal for effectively inhibiting the inflammatory response in both acute and chronic inflammatory conditions.
Since bromelain and quercetin are recommended to be taken together for maximum anti-inflammatory benefit, formulas that contain both ingredients are ideal. This also simplifies the dosing schedule and reduces the total number of capsules needed to be taken throughout the day.
Since bromelain and quercetin are recommended to be taken together for maximum anti-inflammatory benefit, formulas that contain both ingredients are ideal. This also simplifies the dosing schedule and reduces the total number of capsules needed to be taken throughout the day.
4. Quercetin with Bromelain for Allergies
According to this review article, quercetin is known for its antioxidant activity and anti-allergic properties.
A study (2013) that was done on people with chronic rhinosinusitis (inflammation in the sinuses) indicated good tolerability, symptom control, and improvement in QoL (quality of life) for the treatment of CRS (chronic rhinosinusitis) using bromelain tablets.
On top of improving absorption, bromelain together with quercetin, can help alleviate sinus inflammation, with quercetin functioning as an anti-inflammatory.
According to this review article, quercetin is known for its antioxidant activity and anti-allergic properties.
A study (2013) that was done on people with chronic rhinosinusitis (inflammation in the sinuses) indicated good tolerability, symptom control, and improvement in QoL (quality of life) for the treatment of CRS (chronic rhinosinusitis) using bromelain tablets.
On top of improving absorption, bromelain together with quercetin, can help alleviate sinus inflammation, with quercetin functioning as an anti-inflammatory.
5. Quercetin with Bromelain for Hives
Hives, also known as urticaria, are itchy, generalised, raised red discolouration that are found on the skin. They are usually red, pink, or flesh-colored, and sometimes they sting or hurt. In most cases, hives are caused by an allergic reaction to a medication or food or a reaction to an irritant in the environment.
In many cases, hives are an acute (temporary) problem that may be alleviated with allergy medications. Most rashes go away on their own. As with any allergic reaction, if hives are accompanied by difficulty breathing or swallowing, this can be a sign of a much more severe and serious anaphylactic reaction. This requires immediate emergency medical attention to treat. Please see your doctor and go to the nearest 24 hr emergency clinic or hospital immediately.
However, chronic hives can occur over and over. In some cases, the red lesions can result from an allergic reaction to the food you eat.
Dr Deborah Gordon recommends trying a food elimination diet to pinpoint the source of the problem. Thus, if you get rid of the source, you won’t have to worry about treating the hives.
Antihistamine drugs also stop the release of the histamines that cause the hives in an allergic reaction. However, people who suffer from chronic hives don’t usually want to take medication for months or years if they don’t have to.
For this reason, some allergy sufferers turn to natural alternatives such as quercetin; that works by stabilizing the membranes of cells that release histamine. This often helps brings inflammatory and allergic reactions under control. You can buy quercetin products in natural foods stores or Amazon. The best form is a coated 400 mg tablet, taken twice a day between meals; as recommended by Dr Andrew Weil. It can take six to eight weeks of continuous use for quercetin to build up to therapeutic levels in the body.
As mentioned above, bromelain can help to improve the absorption of quercetin to provide greater benefit when taken together.
Hives, also known as urticaria, are itchy, generalised, raised red discolouration that are found on the skin. They are usually red, pink, or flesh-colored, and sometimes they sting or hurt. In most cases, hives are caused by an allergic reaction to a medication or food or a reaction to an irritant in the environment.
In many cases, hives are an acute (temporary) problem that may be alleviated with allergy medications. Most rashes go away on their own. As with any allergic reaction, if hives are accompanied by difficulty breathing or swallowing, this can be a sign of a much more severe and serious anaphylactic reaction. This requires immediate emergency medical attention to treat. Please see your doctor and go to the nearest 24 hr emergency clinic or hospital immediately.
Dr Deborah Gordon recommends trying a food elimination diet to pinpoint the source of the problem. Thus, if you get rid of the source, you won’t have to worry about treating the hives.
Antihistamine drugs also stop the release of the histamines that cause the hives in an allergic reaction. However, people who suffer from chronic hives don’t usually want to take medication for months or years if they don’t have to.
For this reason, some allergy sufferers turn to natural alternatives such as quercetin; that works by stabilizing the membranes of cells that release histamine. This often helps brings inflammatory and allergic reactions under control. You can buy quercetin products in natural foods stores or Amazon. The best form is a coated 400 mg tablet, taken twice a day between meals; as recommended by Dr Andrew Weil. It can take six to eight weeks of continuous use for quercetin to build up to therapeutic levels in the body.
As mentioned above, bromelain can help to improve the absorption of quercetin to provide greater benefit when taken together.
6. Quercetin with Bromelain for Sinusitis
About 35 million Americans develop sinusitis each year. This is inflammation and swelling of the tissue lining the sinuses in your nasal cavity or the areas surrounding your nose (figure below). It can be caused by infections but also nose related problems like a polyps (benign growth), blockages or allergies.
Categorically, there are two types of sinusitis:
Acute sinusitis - an infection that is often triggered by the flu or cold. The flu or cold virus attacks your sinuses causing them to swell and become narrow. Your body responds by producing mucus. When the sinuses become blocked and are filled with mucus, viruses, fungi or bacteria can grow and cause infections that cause pressure and headache.
Chronic sinusitis - an infection that lasts for more than 3 weeks and can continue indefinitely if not treated. It is often caused by allergies, fungal infections or weakened immune system.
For those with chronic or recurring sinusitis, you could consider rinsing your sinuses once or twice a day with a nasal saline solution.
Bromelain helps support the sinuses because of its powerful anti-inflammatory and mucus thinning properties. A 2016 review of studies suggests that bromelain may reduce the duration of sinusitis symptoms in children, improve breathing, and reduce nasal inflammation.
Quercetin has amazing anti-inflammatory and anti-oxidant effects. Since bromelain and quercetin are recommended to be taken together for maximum anti-inflammatory benefit, formulas that contain both ingredients are ideal.
About 35 million Americans develop sinusitis each year. This is inflammation and swelling of the tissue lining the sinuses in your nasal cavity or the areas surrounding your nose (figure below). It can be caused by infections but also nose related problems like a polyps (benign growth), blockages or allergies.
Quercetin has amazing anti-inflammatory and anti-oxidant effects. Since bromelain and quercetin are recommended to be taken together for maximum anti-inflammatory benefit, formulas that contain both ingredients are ideal.
Categorically, there are two types of sinusitis:
Acute sinusitis - an infection that is often triggered by the flu or cold. The flu or cold virus attacks your sinuses causing them to swell and become narrow. Your body responds by producing mucus. When the sinuses become blocked and are filled with mucus, viruses, fungi or bacteria can grow and cause infections that cause pressure and headache.
Chronic sinusitis - an infection that lasts for more than 3 weeks and can continue indefinitely if not treated. It is often caused by allergies, fungal infections or weakened immune system.
Acute sinusitis - an infection that is often triggered by the flu or cold. The flu or cold virus attacks your sinuses causing them to swell and become narrow. Your body responds by producing mucus. When the sinuses become blocked and are filled with mucus, viruses, fungi or bacteria can grow and cause infections that cause pressure and headache.
Chronic sinusitis - an infection that lasts for more than 3 weeks and can continue indefinitely if not treated. It is often caused by allergies, fungal infections or weakened immune system.
For those with chronic or recurring sinusitis, you could consider rinsing your sinuses once or twice a day with a nasal saline solution.
Bromelain helps support the sinuses because of its powerful anti-inflammatory and mucus thinning properties. A 2016 review of studies suggests that bromelain may reduce the duration of sinusitis symptoms in children, improve breathing, and reduce nasal inflammation.
Quercetin has amazing anti-inflammatory and anti-oxidant effects. Since bromelain and quercetin are recommended to be taken together for maximum anti-inflammatory benefit, formulas that contain both ingredients are ideal.
7. Quercetin with Bromelain for Weight Loss
Some people believe that consuming quercetin, whether in foods or as a natural supplement, can help promote weight loss.
However, there have been mixed reviews and conclusions on the effects of quercetin for weight loss and its effect on the expression of certain genes.
These inconsistent findings from the studies maybe are due to the difference in the range of fitness of the subjects, differences in research design, different methods in the preparation of quercetin extract, etc. In order to assist you in doing your own research, let's dive into some relevant studies and reviews.
Matthew Solan, author of Doctor’s Detox Diet reports that quercetin can mimic the effect of calorie restriction. However, it shows to have a greater effect on weight loss when combined with other fat-fighting phytochemicals such as resveratrol and genistein.
Another interesting side effect of quercetin, as reported by MuscularDevelopment.com, is that quercetin may offer some of the same psychostimulant properties of caffeine.
Therefore, consuming it may help people increase their activity throughout the day and delay fatigue. Plus, this can lead to expending more energy during workouts, thus burning more calories.
Dr Josh Axe also adds that some athletic supplements contain quercetin because some people believe that is increases endurance and athletic performance.
In a biochemical study, quercetin exerts anti-fat cell formations at the molecular level.
In another study, a combination of Quercetin along with Resveratrol inhibited the formation of mature fat cells, which subsequently resulted in weight loss. Quercetin increases the secretion of the enzyme, triglyceride lipase that breaks down fat, thus aiding in weight loss.
It was also discovered that consumption of 500 mg of quercetin twice a day increased the VO2 max (the maximum amount of oxygen that is utilised by an individual) in untrained individuals as a result of an increase in mitochondrial biogenesis.
This enhancement in fitness without exercise training can be used in disease prevention such as obesity.
In two animal studies, supplementation with quercetin brought about a significant reduction in obesity related gene expression.
Since bromelain can help to improve the absorption of quercetin, there should be greater benefit when quercetin and bromelain are taken together.
Some people believe that consuming quercetin, whether in foods or as a natural supplement, can help promote weight loss.
However, there have been mixed reviews and conclusions on the effects of quercetin for weight loss and its effect on the expression of certain genes.
These inconsistent findings from the studies maybe are due to the difference in the range of fitness of the subjects, differences in research design, different methods in the preparation of quercetin extract, etc. In order to assist you in doing your own research, let's dive into some relevant studies and reviews.
These inconsistent findings from the studies maybe are due to the difference in the range of fitness of the subjects, differences in research design, different methods in the preparation of quercetin extract, etc. In order to assist you in doing your own research, let's dive into some relevant studies and reviews.
Matthew Solan, author of Doctor’s Detox Diet reports that quercetin can mimic the effect of calorie restriction. However, it shows to have a greater effect on weight loss when combined with other fat-fighting phytochemicals such as resveratrol and genistein.
Another interesting side effect of quercetin, as reported by MuscularDevelopment.com, is that quercetin may offer some of the same psychostimulant properties of caffeine.
Therefore, consuming it may help people increase their activity throughout the day and delay fatigue. Plus, this can lead to expending more energy during workouts, thus burning more calories.
Dr Josh Axe also adds that some athletic supplements contain quercetin because some people believe that is increases endurance and athletic performance.
Therefore, consuming it may help people increase their activity throughout the day and delay fatigue. Plus, this can lead to expending more energy during workouts, thus burning more calories.
Dr Josh Axe also adds that some athletic supplements contain quercetin because some people believe that is increases endurance and athletic performance.
It was also discovered that consumption of 500 mg of quercetin twice a day increased the VO2 max (the maximum amount of oxygen that is utilised by an individual) in untrained individuals as a result of an increase in mitochondrial biogenesis.
This enhancement in fitness without exercise training can be used in disease prevention such as obesity.
In two animal studies, supplementation with quercetin brought about a significant reduction in obesity related gene expression.
Since bromelain can help to improve the absorption of quercetin, there should be greater benefit when quercetin and bromelain are taken together.
8. Inflammation vs Allergies vs Hives vs Sinusitis?
Confused? In general, there are two types of allergies; generalised and local. Hives are generalised allergies, could be triggered by food (e.g. peanuts) or antibiotics or certain medications. Local allergies instead affect a certain area of the body e.g. scalp (allergic to hair dye) or face (allergic to certain make-up).
Allergies are triggered by allergens (an allergen is normally a foreign substance that can cause an allergic reaction) leading to inflammation. However, inflammation can also be triggered not only by allergens but also by bacterial or viral infections.
For example an acne is a skin infection with inflammation. Inflammation associated with an infection is not considered an allergy. Therefore, the treatment approach is different.
Sinusitis basically means inflammation of the nasal sinuses (refer to the figure above). It could be related to an allergy or infection.
Confused? In general, there are two types of allergies; generalised and local. Hives are generalised allergies, could be triggered by food (e.g. peanuts) or antibiotics or certain medications. Local allergies instead affect a certain area of the body e.g. scalp (allergic to hair dye) or face (allergic to certain make-up).
Allergies are triggered by allergens (an allergen is normally a foreign substance that can cause an allergic reaction) leading to inflammation. However, inflammation can also be triggered not only by allergens but also by bacterial or viral infections.
For example an acne is a skin infection with inflammation. Inflammation associated with an infection is not considered an allergy. Therefore, the treatment approach is different.
Sinusitis basically means inflammation of the nasal sinuses (refer to the figure above). It could be related to an allergy or infection.
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